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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of complement activation
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Accession:GO:0045916 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: down regulation of complement activation;   downregulation of complement activation;   negative regulation of complement cascade
 narrow_synonym: inhibition of complement activation


show annotations for term's descendants           Sort by:
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule, decay accelerating factor for complement involved_in ISO RGD
MGI		 PMID:10929073 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:2326180 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd55b CD55 molecule, decay accelerating factor for complement B involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 1:130,316,263...130,350,831
Ensembl chr 1:130,316,274...130,350,746 		JBrowse link
G Cd59a CD59a antigen involved_in IDA (MGI:3828358|PMID:17237428) BHF-UCL PMID:17237428 MGI:3828358 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen acts_upstream_of_or_within IDA (PMID:10946279) MGI PMID:10946279 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within
involved_in		 ISO
IMP		 (PMID:10642554) RGD
MGI		 PMID:10642554 PMID:11861390 GO_REF:0000096 MGI:4417868 RGD:625470 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59a CD59a antigen involved_in
acts_upstream_of_or_within		 IMP
IBA
IDA
ISO		 (MGI:3828358|PMID:17237428)
(PMID:11471050)		 BHF-UCL
GO_Central
MGI		 PMID:11471050 PMID:17237428 GO_REF:0000033 GO_REF:0000096 MGI:3828358 MGI:4417868 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen acts_upstream_of_or_within
involved_in		 ISO
IDA
IBA		 (PMID:10946279), (PMID:11471050) RGD
MGI
GO_Central		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1600482 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 antigen, complement regulatory protein involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:182,591,609...182,724,161
Ensembl chr 1:182,591,425...182,724,156 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bp complement component 4 binding protein involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369 		JBrowse link
G Cd46 CD46 antigen, complement regulatory protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Cr2 complement receptor 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,819,120...194,859,096
Ensembl chr 1:194,819,119...194,859,024 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:182,591,609...182,724,161
Ensembl chr 1:182,591,425...182,724,156 		JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:58,042,796...58,206,596
Ensembl chr 4:58,042,442...58,206,859 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3134
      immune effector process 874
        negative regulation of immune effector process 154
          negative regulation of complement activation 15
            negative regulation of activation of membrane attack complex 2
            negative regulation of complement activation, alternative pathway 3
            negative regulation of complement activation, classical pathway 7
            negative regulation of complement activation, lectin pathway 2
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13112
      regulation of biological process 12722
        positive regulation of biological process 6853
          positive regulation of immune system process 1238
            positive regulation of immune response 830
              activation of immune response 599
                complement activation 68
                  regulation of complement activation 26
                    negative regulation of complement activation 15
                      negative regulation of activation of membrane attack complex 2
                      negative regulation of complement activation, alternative pathway 3
                      negative regulation of complement activation, classical pathway 7
                      negative regulation of complement activation, lectin pathway 2
paths to the root