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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of complement activation
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Accession:GO:0045916 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: down regulation of complement activation;   downregulation of complement activation;   negative regulation of complement cascade
 narrow_synonym: inhibition of complement activation



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negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule (Cromer blood group) involved_in IDA
IMP
ISO
(PMID:6211481)
(PMID:28657829)
UniProt
UniProt
RGD
PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chr 1:207,321,674...207,360,966
Ensembl chr 1:207,321,532...207,386,804
JBrowse link
G CD59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (MGI:1888643|PMID:10946279) MGI PMID:10946279 MGI:1888643 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA (PMID:31862673) ARUK-UCL
ARUK-UCL
PMID:31862673 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
G CR1L complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (MGI:1351571|PMID:10642554) RGD
MGI
PMID:10642554 PMID:11861390 MGI:1351571 RGD:625470 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416
JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IDA (PMID:11485744) UniProt
UniProt
PMID:11485744 NCBI chr 3:187,217,282...187,293,529
Ensembl chr 3:187,217,282...187,291,980
JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL049629.2 novel protein involved_in IEA InterPro
InterPro
GO_REF:0000002 Ensembl chr11:33,698,261...33,722,467 JBrowse link
G CD59 CD59 molecule (CD59 blood group) involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
(PMID:21873635)
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
InterPro
GO_Central
InterPro
MGI
RGD
GO_Central
PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 GO_REF:0000002 MGI:1888643 MGI:2148385 RGD:1600482 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of IDA (PMID:31862673) ARUK-UCL
ARUK-UCL
PMID:31862673 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,054...207,795,513
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA (PMID:10531307) UniProt
UniProt
PMID:10531307 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
G SUSD4 sushi domain containing 4 involved_in IBA
IDA
(PMID:21873635)
(PMID:23482636)
GO_Central
UniProt
GO_Central
UniProt
PMID:21873635 PMID:23482636 NCBI chr 1:223,220,826...223,365,271
Ensembl chr 1:223,220,819...223,364,233
JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IPI
IBA
(PMID:17051150)
(PMID:21873635)
UniProt
UniProt
GO_Central
GO_Central
PMID:17051150 PMID:21873635 NCBI chr  X:66,021,738...66,040,092
Ensembl chr  X:66,021,738...66,040,125
JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4BPA complement component 4 binding protein alpha involved_in IDA
IBA
(PMID:22333221)
(PMID:21873635)
BHF-UCL
BHF-UCL
GO_Central
GO_Central
PMID:21873635 PMID:22333221 NCBI chr 1:207,104,232...207,144,972
Ensembl chr 1:207,104,233...207,144,972
JBrowse link
G C4BPB complement component 4 binding protein beta involved_in IDA (PMID:22333221) BHF-UCL
BHF-UCL
PMID:22333221 NCBI chr 1:207,088,795...207,099,993
Ensembl chr 1:207,088,860...207,099,993
JBrowse link
G CD46 CD46 molecule involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,054...207,795,513
JBrowse link
G CD55 CD55 molecule (Cromer blood group) involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:207,321,674...207,360,966
Ensembl chr 1:207,321,532...207,386,804
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA
IBA
(PMID:10531307), (PMID:6910481)
(PMID:21873635)
UniProt
UniProt
GO_Central
GO_Central
PMID:6910481 PMID:10531307 PMID:21873635 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
G CR1L complement C3b/C4b receptor 1 like involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416
JBrowse link
G CR2 complement C3d receptor 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,454,230...207,489,895
JBrowse link
G SUSD4 sushi domain containing 4 involved_in IDA
IBA
(PMID:23482636)
(PMID:21873635)
UniProt
GO_Central
UniProt
GO_Central
PMID:21873635 PMID:23482636 NCBI chr 1:223,220,826...223,365,271
Ensembl chr 1:223,220,819...223,364,233
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IDA (PMID:12538697) UniProt
UniProt
PMID:12538697 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G SERPING1 serpin family G member 1 involved_in IDA (PMID:10946292) UniProt
UniProt
PMID:10946292 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18661
    immune system process 3127
      immune effector process 746
        negative regulation of immune effector process 130
          negative regulation of complement activation 14
            negative regulation of activation of membrane attack complex 3
            negative regulation of complement activation, alternative pathway + 4
            negative regulation of complement activation, classical pathway + 8
            negative regulation of complement activation, lectin pathway + 2
            suppression by virus of host complement activation 0
Path 2
Term Annotations click to browse term
  biological_process 18661
    biological regulation 13218
      regulation of biological process 12506
        positive regulation of biological process 6904
          positive regulation of immune system process 1054
            positive regulation of immune response 673
              activation of immune response 442
                complement activation 147
                  regulation of complement activation 29
                    negative regulation of complement activation 14
                      negative regulation of activation of membrane attack complex 3
                      negative regulation of complement activation, alternative pathway + 4
                      negative regulation of complement activation, classical pathway + 8
                      negative regulation of complement activation, lectin pathway + 2
                      suppression by virus of host complement activation 0
paths to the root