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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of complement activation
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Accession:GO:0045916 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: down regulation of complement activation;   downregulation of complement activation;   negative regulation of complement cascade
 narrow_synonym: inhibition of complement activation


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negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:6211481)
(PMID:28657829)
RGD
UniProt
PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chrNW_004955406:42,773,368...42,796,205 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (MGI:1888643|PMID:10946279) MGI PMID:10946279 MGI:1888643 NCBI chrNW_004955422:12,500,572...12,528,738 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chrNW_004955420:20,540,266...20,605,830
Ensembl chrNW_004955420:20,540,016...20,605,854
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050) RGD
MGI
PMID:10946279 PMID:11471050 PMID:15843577 MGI:1888643 MGI:2148385 RGD:1600482 NCBI chrNW_004955422:12,500,572...12,528,738 JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chrNW_004955520:1,444,618...1,523,214
Ensembl chrNW_004955520:1,444,618...1,523,260
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO (PMID:17051150) UniProt PMID:17051150 NCBI chrNW_004955475:5,461,512...5,481,552
Ensembl chrNW_004955475:5,461,064...5,481,564
JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein alpha involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004955406:42,613,659...42,641,918
Ensembl chrNW_004955406:42,613,607...42,641,670
JBrowse link
G C4bpb complement component 4 binding protein beta involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004955406:42,601,164...42,608,912 JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chrNW_004955520:1,444,618...1,523,214
Ensembl chrNW_004955520:1,444,618...1,523,260
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102021956 alpha-2-macroglobulin involved_in ISO (PMID:12538697) UniProt PMID:12538697 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Serping1 serpin family G member 1 involved_in ISO (PMID:10946292) UniProt PMID:10946292 NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12107
    immune system process 1969
      immune effector process 494
        negative regulation of immune effector process 106
          negative regulation of complement activation 10
            negative regulation of activation of membrane attack complex 1
            negative regulation of complement activation, alternative pathway + 3
            negative regulation of complement activation, classical pathway + 4
            negative regulation of complement activation, lectin pathway + 2
            suppression by virus of host complement activation 0
Path 2
Term Annotations click to browse term
  biological_process 12107
    biological regulation 8915
      regulation of biological process 8459
        positive regulation of biological process 5563
          positive regulation of immune system process 744
            positive regulation of immune response 414
              activation of immune response 221
                complement activation 35
                  regulation of complement activation 19
                    negative regulation of complement activation 10
                      negative regulation of activation of membrane attack complex 1
                      negative regulation of complement activation, alternative pathway + 3
                      negative regulation of complement activation, classical pathway + 4
                      negative regulation of complement activation, lectin pathway + 2
                      suppression by virus of host complement activation 0
paths to the root