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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of DNA recombination
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Accession:GO:0045910 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
Synonyms:exact_synonym: down regulation of DNA recombination;   downregulation of DNA recombination
 narrow_synonym: inhibition of DNA recombination


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negative regulation of DNA recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase involved_in ISO (PMID:9671747) RGD PMID:9671747 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G H1f0 H1.0 linker histone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694 		JBrowse link
G H1f1 H1.1 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011 		JBrowse link
G H1f10 H1.10 linker histone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448 		JBrowse link
G H1f2 H1.2 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635 		JBrowse link
G H1f4 H1.4 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403 		JBrowse link
G H1f5 H1.5 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:42,726,132...42,727,162
Ensembl chr17:42,726,127...42,769,160 		JBrowse link
G H1f6 H1.6 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:41,427,365...41,428,109
Ensembl chr17:41,427,323...41,428,119 		JBrowse link
G H1f7 H1.7 linker histone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:129,408,521...129,409,888
Ensembl chr 7:129,408,359...129,409,930 		JBrowse link
G H1f8 H1.8 linker histone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:148,993,133...148,998,254
Ensembl chr 4:148,993,133...148,998,254 		JBrowse link
G H4f3 H1.3 linker histone, cluster member involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334 		JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321 		JBrowse link
G Lig3 DNA ligase 3 acts_upstream_of_or_within ISO MGI:3629052 (MGI:3625660|PMID:16648486) RGD PMID:16648486 MGI:3625660 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:17715146)
GO_REF:0000107
MGI:1858055 (MGI:1351797|PMID:10545954), (MGI:74950|PMID:7628020)		 RGD
Ensembl		 PMID:7628020 PMID:10545954 PMID:17715146 GO_REF:0000107 MGI:1351797 MGI:74950 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 involved_in ISO (PMID:17715146) RGD PMID:17715146 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:17715146)
MGI:2151803 (MGI:1351797|PMID:10545954)		 RGD PMID:10545954 PMID:17715146 MGI:1351797 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3835812 (MGI:2448116|PMID:12509447) RGD PMID:12509447 MGI:2448116 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in IBA
ISO		 PMID:21873635
(MGI:5645200|PMID:22579284)		 RGD PMID:22579284 PMID:21873635 MGI:5645200, RGD:13792537 NCBI chr 3:168,427,247...168,465,349
Ensembl chr 3:168,419,579...168,465,348 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in ISO (PMID:22704558) RGD PMID:22704558 NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670 		JBrowse link
negative regulation of DNA recombination at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pot1b protection of telomeres 1B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532 		JBrowse link
G Terf2ip TERF2 interacting protein involved_in ISS
ISO		 GO_REF:0000024
(MGI:4440768|PMID:20339076), (MGI:4839412|PMID:20622869)		 UniProt
RGD		 PMID:20339076 PMID:20622869 GO_REF:0000024 MGI:4440768 MGI:4839412 NCBI chr19:39,976,965...39,984,055
Ensembl chr19:39,976,906...39,984,064 		JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:9461559) RGD PMID:9461559 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in IBA
ISO		 PMID:21873635
(PMID:30356214), (PMID:31544964)
(MGI:6241455|PMID:30356214), (MGI:6370284|PMID:31544964)		 RGD PMID:30356214 PMID:31544964 PMID:21873635 MGI:6241455 MGI:6370284, RGD:13792537 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Fancb FA complementation group B acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:2156841 (MGI:5648586|PMID:25520194)
PMID:21873635		 RGD PMID:25520194 PMID:21873635 MGI:5648586, RGD:13792537 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (PMID:19736316)
(MGI:5566975|PMID:24108124)		 RGD PMID:19736316 PMID:24108124 MGI:5566975 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Helb DNA helicase B involved_in ISO (PMID:26774285)
(MGI:5766842|PMID:26774285)		 RGD PMID:26774285 MGI:5766842 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
IEA		 (PMID:32832608)
GO_REF:0000107		 RGD
Ensembl		 PMID:32832608 GO_REF:0000107 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27561354), (PMID:35219381)		 UniProt
RGD		 PMID:27561354 PMID:35219381 GO_REF:0000024 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069 		JBrowse link
G Kmt5a lysine methyltransferase 5A involved_in ISO (PMID:27338793) RGD PMID:27338793 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Parpbp PARP1 binding protein involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:22153967)
PMID:21873635
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:22153967 PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:13792537 NCBI chr 7:22,511,427...22,580,834
Ensembl chr 7:22,511,427...22,573,695 		JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:25642963)
(MGI:5621198|PMID:25642960)		 RGD PMID:25642960 PMID:25642963 MGI:5621198 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Radx RPA1 related single stranded DNA binding protein, X-linked involved_in ISO
ISS
IEA		 (PMID:28735897)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:28735897 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:103,089,284...103,176,840
Ensembl chr  X:103,089,284...103,176,838 		JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO MGI:2448558 (MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:5648586 NCBI chr10:101,126,544...101,165,739
Ensembl chr10:101,126,547...101,165,652 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23333306)
(MGI:5468037|PMID:23306437), (MGI:5476381|PMID:23333305)		 RGD PMID:23306437 PMID:23333305 PMID:23333306 MGI:5468037 MGI:5476381 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Rmi2 RecQ mediated genome instability 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235 		JBrowse link
G Senp3 SUMO specific peptidase 3 involved_in ISO (PMID:32832608) RGD PMID:32832608 NCBI chr10:54,390,698...54,399,590
Ensembl chr10:54,390,694...54,399,593 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA		 (PMID:29656893)
PMID:21873635		 RGD PMID:29656893 PMID:21873635 RGD:13792537 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 2:35,297,255...35,302,071
Ensembl chr 2:35,295,859...35,302,346 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:25294876) RGD PMID:25294876 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23333306), (PMID:23345425)
(MGI:5476381|PMID:23333305), (MGI:5887194|PMID:20362325)		 RGD PMID:20362325 PMID:23333305 PMID:23333306 PMID:23345425 MGI:5476381 MGI:5887194 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:30612738) RGD PMID:30612738 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934 		JBrowse link
G Thoc1 THO complex subunit 1 involved_in ISO (MGI:5520039|PMID:22144908) RGD PMID:22144908 MGI:5520039 NCBI chr18:983,824...1,019,123
Ensembl chr18:983,824...1,019,114 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:3695433 (MGI:3694584|PMID:17137798)
GO_REF:0000107		 RGD
Ensembl		 PMID:17137798 GO_REF:0000107 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
negative regulation of mitotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 involved_in ISO UniProtKB:O88700 (MGI:5800654|PMID:27010503) RGD PMID:27010503 MGI:5800654 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Blm BLM RecQ like helicase acts_upstream_of_or_within
involved_in		 ISO MGI:1857708|MGI:2158669|MGI:2158670|MGI:3053044|MGI:3663359 (MGI:1312959|PMID:9808625), (MGI:1928200|PMID:11101838), (MGI:3655554|PMID:16914751), (MGI:3700903|PMID:17210642)
UniProtKB:A8VU90 (MGI:5800654|PMID:27010503)		 RGD PMID:9808625 PMID:11101838 PMID:16914751 PMID:17210642 PMID:27010503 MGI:1312959 MGI:1928200 MGI:3655554 MGI:3700903 MGI:5800654 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1858054 (MGI:3513725|PMID:15480418)
GO_REF:0000107		 RGD
Ensembl		 PMID:15480418 GO_REF:0000107 MGI:3513725 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
negative regulation of telomere maintenance via recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA		 (PMID:15507207)
(MGI:5883205|PMID:24120135)
PMID:21873635		 RGD PMID:15507207 PMID:24120135 PMID:21873635 MGI:5883205, RGD:13792537 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19527
    metabolic process 11509
      negative regulation of metabolic process 3023
        negative regulation of macromolecule metabolic process 2789
          negative regulation of DNA metabolic process 153
            negative regulation of DNA recombination 52
              inactivation of recombination (HML) 0
              negative regulation of DNA recombination at centromere 0
              negative regulation of DNA recombination at telomere + 3
              negative regulation of double-strand break repair via homologous recombination + 22
              negative regulation of isotype switching + 6
              negative regulation of mitotic recombination + 4
              negative regulation of reciprocal meiotic recombination 0
              negative regulation of single-strand break repair via homologous recombination 0
              negative regulation of strand invasion 0
Path 2
Term Annotations click to browse term
  biological_process 19527
    metabolic process 11509
      cellular metabolic process 10105
        cellular aromatic compound metabolic process 5666
          nucleobase-containing compound metabolic process 5433
            nucleic acid metabolic process 4945
              DNA metabolic process 994
                DNA recombination 327
                  regulation of DNA recombination 136
                    negative regulation of DNA recombination 52
                      inactivation of recombination (HML) 0
                      negative regulation of DNA recombination at centromere 0
                      negative regulation of DNA recombination at telomere + 3
                      negative regulation of double-strand break repair via homologous recombination + 22
                      negative regulation of isotype switching + 6
                      negative regulation of mitotic recombination + 4
                      negative regulation of reciprocal meiotic recombination 0
                      negative regulation of single-strand break repair via homologous recombination 0
                      negative regulation of strand invasion 0
paths to the root