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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of smoothened signaling pathway
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Accession:GO:0045880 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of smoothened signaling.
Synonyms:exact_synonym: positive regulation of hedgehog signaling pathway;   positive regulation of hh signaling pathway;   positive regulation of smoothened signalling pathway;   up regulation of smoothened signaling pathway;   upregulation of smoothened signaling pathway
 narrow_synonym: activation of smoothened signaling pathway;   stimulation of smoothened signaling pathway
 related_synonym: positive regulation of smoothened by patched;   positive regulation of smoothened receptor activity by patched
 alt_id: GO:0045878


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positive regulation of smoothened signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc9 armadillo repeat containing 9 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6152361|PMID:29459677)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29459677 GO_REF:0000024 GO_REF:0000107 MGI:6152361 NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 acts_upstream_of_or_within ISO MGI:5007063 (MGI:5316547|PMID:22280990) RGD PMID:22280990 MGI:5316547 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570
JBrowse link
G Cibar1 CBY1 interacting BAR domain containing 1 involved_in ISO (MGI:6152361|PMID:29459677) RGD PMID:29459677 MGI:6152361 NCBI chr 5:25,732,457...25,750,953
Ensembl chr 5:25,732,644...25,750,826
JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:108075 (MGI:3619284|PMID:16543460) RGD PMID:16543460 MGI:3619284 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Dcdc2 doublecortin domain containing 2 involved_in ISO (PMID:21698230) RGD PMID:21698230 NCBI chr17:41,838,201...42,031,265
Ensembl chr17:41,838,201...42,031,265
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (MGI:5617062|PMID:25644602) RGD PMID:25644602 MGI:5617062 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4359237 (MGI:3804352|PMID:18488998)
Ensembl
RGD
PMID:18488998 GO_REF:0000107 MGI:3804352 NCBI chr 8:5,217,054...5,436,969
Ensembl chr 8:5,217,217...5,429,581
JBrowse link
G Evc EvC ciliary complex subunit 1 involved_in ISO (MGI:3720528|PMID:17660199) RGD PMID:17660199 MGI:3720528 NCBI chr14:78,213,601...78,253,266
Ensembl chr14:78,213,635...78,253,266
JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of_or_within ISO MGI:2135961 (MGI:3621094|PMID:16540513), (MGI:3629544|PMID:16778080) RGD PMID:16540513 PMID:16778080 MGI:3621094 MGI:3629544 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1347476 (MGI:5486225|PMID:23383217)
Ensembl
RGD
PMID:23383217 GO_REF:0000107 MGI:5486225 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472 (MGI:5486225|PMID:23383217) RGD PMID:23383217 MGI:5486225 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Gas1 growth arrest-specific 1 acts_upstream_of_or_within ISO MGI:2388397|MGI:3711070 (MGI:3710452|PMID:17504940), (MGI:3713422|PMID:17525797) RGD PMID:17504940 PMID:17525797 MGI:3710452 MGI:3713422 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gas8 growth arrest specific 8 involved_in ISS
ISO
GO_REF:0000024
(MGI:6148647|PMID:21659505)
UniProt
RGD
PMID:21659505 GO_REF:0000024 MGI:6148647 NCBI chr19:56,316,367...56,335,873
Ensembl chr19:56,316,268...56,335,870
JBrowse link
G Gli1 GLI family zinc finger 1 involved_in ISO (PMID:17035233) RGD PMID:17035233 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gpc3 glypican 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2159355 (MGI:4367926|PMID:19733558)
Ensembl
RGD
PMID:19733558 GO_REF:0000107 MGI:4367926 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Ift172 intraflagellar transport 172 acts_upstream_of_or_within ISO MGI:2682066 (MGI:3804352|PMID:18488998) RGD PMID:18488998 MGI:3804352 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:5142377|PMID:11517919) RGD PMID:11517919 MGI:5142377 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Intu inturned planar cell polarity protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4441401 (MGI:5545722|PMID:22935613)
Ensembl
RGD
PMID:22935613 GO_REF:0000107 MGI:5545722 NCBI chr 2:127,459,089...127,521,327
Ensembl chr 2:127,459,012...127,525,437
JBrowse link
G Kif7 kinesin family member 7 involved_in ISO (MGI:4355635|PMID:19666503), (MGI:4357736|PMID:19549984) RGD PMID:19549984 PMID:19666503 MGI:4355635 MGI:4357736 NCBI chr 1:141,434,183...141,452,592
Ensembl chr 1:141,434,625...141,451,075
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 acts_upstream_of_or_within ISO MGI:98297 (MGI:3588476|PMID:16020517) RGD PMID:16020517 MGI:3588476 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Pdcl phosducin-like involved_in ISS
ISO
GO_REF:0000024
(MGI:6111022|PMID:29290584)
UniProt
RGD
PMID:29290584 GO_REF:0000024 MGI:6111022 NCBI chr 3:21,602,349...21,609,821
Ensembl chr 3:21,601,816...21,609,853
JBrowse link
G Por cytochrome p450 oxidoreductase IMP RGD PMID:19264869 RGD:2316785 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prrx1 paired related homeobox 1 acts_upstream_of_or_within ISO MGI:98218 (MGI:2149056|PMID:11532916) RGD PMID:11532916 MGI:2149056 NCBI chr13:81,147,038...81,215,559
Ensembl chr13:81,147,348...81,214,546
JBrowse link
G Prrx2 paired related homeobox 2 acts_upstream_of_or_within ISO MGI:97712 (MGI:2149056|PMID:11532916) RGD PMID:11532916 MGI:2149056 NCBI chr 3:9,681,871...9,718,051
Ensembl chr 3:9,681,871...9,718,051
JBrowse link
G Rab34 RAB34, member RAS oncogene family involved_in ISS
ISO
GO_REF:0000024
(MGI:6111022|PMID:29290584)
UniProt
RGD
PMID:29290584 GO_REF:0000024 MGI:6111022 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Scube1 signal peptide, CUB domain and EGF like domain containing 1 acts_upstream_of_or_within ISO (MGI:5698232|PMID:25639508) RGD PMID:25639508 MGI:5698232 NCBI chr 7:124,501,988...124,620,755
Ensembl chr 7:124,501,988...124,620,703
JBrowse link
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 acts_upstream_of_or_within ISO (MGI:5698232|PMID:25639508) RGD PMID:25639508 MGI:5698232 NCBI chr 1:174,428,056...174,495,356
Ensembl chr 1:174,428,699...174,495,258
JBrowse link
G Scube3 signal peptide, CUB domain and EGF like domain containing 3 acts_upstream_of_or_within ISO (MGI:5698232|PMID:25639508) RGD PMID:25639508 MGI:5698232 NCBI chr20:7,718,260...7,749,847
Ensembl chr20:7,718,282...7,746,331
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:17035233)
GO_REF:0000107
RGD
Ensembl
PMID:17035233 GO_REF:0000107 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5142377|PMID:11517919)
GO_REF:0000107
(PMID:19561609)
UniProt
RGD
Ensembl
PMID:11517919 PMID:19561609 GO_REF:0000024 GO_REF:0000107 MGI:5142377 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Shox2 short stature homeobox 2 acts_upstream_of_or_within ISO MGI:3605739 (MGI:3714677|PMID:17481601) RGD PMID:17481601 MGI:3714677 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783
JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO MGI:5300464 (MGI:5300220|PMID:21937600) RGD PMID:21937600 MGI:5300220 NCBI chr18:73,145,596...73,199,395
Ensembl chr18:73,157,973...73,193,377
JBrowse link
G Smo smoothened, frizzled class receptor involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
(MGI:3616743|PMID:16459297)
GO_REF:0000107
RGD
Ensembl
PMID:16459297, PMID:21873635 GO_REF:0000107 MGI:3616743, RGD:13792537 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Stk36 serine/threonine kinase 36 involved_in ISO (MGI:4943382|PMID:18600476) RGD PMID:18600476 MGI:4943382 NCBI chr 9:81,880,175...81,908,014
Ensembl chr 9:81,880,177...81,907,273
JBrowse link
G Tedc1 tubulin epsilon and delta complex 1 involved_in ISO (MGI:6152361|PMID:29459677) RGD PMID:29459677 MGI:6152361 NCBI chr 6:137,967,119...137,976,324
Ensembl chr 6:137,967,401...137,980,217
JBrowse link
G Tedc2 tubulin epsilon and delta complex 2 involved_in ISO (MGI:6152361|PMID:29459677) RGD PMID:29459677 MGI:6152361 NCBI chr10:13,586,852...13,591,938
Ensembl chr10:13,586,648...13,591,953
JBrowse link
G Ttc23 tetratricopeptide repeat domain 23 involved_in ISS
ISO
GO_REF:0000024
(MGI:6152361|PMID:29459677)
UniProt
RGD
PMID:29459677 GO_REF:0000024 MGI:6152361 NCBI chr 1:128,604,324...128,687,900
Ensembl chr 1:128,606,770...128,687,893
JBrowse link
G Tubd1 tubulin, delta 1 involved_in ISO (MGI:6111022|PMID:29290584) RGD PMID:29290584 MGI:6111022 NCBI chr10:73,865,828...73,886,976
Ensembl chr10:73,868,943...73,886,669
JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in ISS
ISO
GO_REF:0000024
(MGI:6152361|PMID:29459677)
UniProt
RGD
PMID:29459677 GO_REF:0000024 MGI:6152361 NCBI chr17:9,429,171...9,441,628
Ensembl chr17:9,429,175...9,441,526
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 involved_in ISO (PMID:28992318) RGD PMID:28992318 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811
JBrowse link
G Ulk3 unc-51 like kinase 3 involved_in ISO
ISS
(PMID:19878745), (PMID:20643644)
GO_REF:0000024
RGD
UniProt
PMID:19878745 PMID:20643644 GO_REF:0000024 NCBI chr 8:62,368,548...62,375,229
Ensembl chr 8:62,368,998...62,374,504
JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO MGI:3701350 (MGI:3701031|PMID:16818445) RGD PMID:16818445 MGI:3701031 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link
positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gorab golgin, RAB6-interacting acts_upstream_of_or_within ISO (MGI:5766823|PMID:26967474) RGD PMID:26967474 MGI:5766823 NCBI chr13:81,682,207...81,698,827
Ensembl chr13:81,682,018...81,698,833
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18344
      signal transduction 6881
        positive regulation of signal transduction 1597
          positive regulation of smoothened signaling pathway 43
            positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13514
      regulation of biological process 12772
        regulation of cellular process 12273
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              smoothened signaling pathway 158
                regulation of smoothened signaling pathway 94
                  positive regulation of smoothened signaling pathway 43
                    positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1
paths to the root