Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of smoothened signaling pathway
go back to main search page
Accession:GO:0045879 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
Synonyms:exact_synonym: down regulation of smoothened signaling pathway;   downregulation of smoothened signaling pathway;   negative regulation of hedgehog signaling pathway;   negative regulation of hh signaling pathway;   negative regulation of smoothened signalling pathway
 narrow_synonym: inhibition of smoothened signaling pathway;   negative regulation of smoothened by patched
 related_synonym: negative regulation of smoothened activity;   negative regulation of smoothened receptor activity by patched
 alt_id: GO:0045877


show annotations for term's descendants           Sort by:
 
negative regulation of smoothened signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd3e CD3e molecule ISO (MGI:MGI:1888832|PMID:10981962) RGD PMID:10981962 MGI:MGI:1888832 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO MGI:MGI:1931521 (MGI:MGI:1307032|PMID:9811582) RGD PMID:9811582 MGI:MGI:1307032 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Gas1 growth arrest-specific 1 ISO (MGI:MGI:2150860|PMID:11572986) RGD PMID:11572986 MGI:MGI:2150860 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gli2 GLI family zinc finger 2 ISO MGI:MGI:1932386 (MGI:MGI:6094959|PMID:28778798) RGD PMID:28778798 MGI:MGI:6094959 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:MGI:4355451|PMID:19667090) RGD PMID:19667090 MGI:MGI:4355451 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Glis2 GLIS family zinc finger 2 ISO (MGI:MGI:5292436|PMID:21816948) RGD PMID:21816948 MGI:MGI:5292436 NCBI chr10:11,154,459...11,177,063
Ensembl chr10:11,154,658...11,174,861
JBrowse link
G Gpc3 glypican 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
MGI:MGI:2159356|MGI:MGI:96533 (MGI:MGI:3790551|PMID:18477453), (MGI:MGI:4430672|PMID:19590577)
Ensembl
UniProt
RGD
PMID:18477453, PMID:19590577 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3790551, MGI:MGI:4430672 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 ISO
IEA
MGI:MGI:5439169 (MGI:MGI:5512663|PMID:24062445)
GO_REF:0000107
RGD
Ensembl
PMID:24062445 GO_REF:0000107, MGI:MGI:5512663 NCBI chr13:51,985,698...51,992,547
Ensembl chr13:51,985,684...51,992,693
JBrowse link
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 ISO (PMID:31010679) RGD PMID:31010679 NCBI chr20:26,755,948...26,831,267
Ensembl chr20:26,755,911...26,830,931
JBrowse link
G Hhip Hedgehog-interacting protein ISO MGI:MGI:2450891 (MGI:MGI:1333378|PMID:10050855), (MGI:MGI:2450020|PMID:12569124), (MGI:MGI:5284801|PMID:15294024) RGD PMID:10050855, PMID:12569124, PMID:15294024 MGI:MGI:1333378, MGI:MGI:2450020, MGI:MGI:5284801 NCBI chr19:31,525,134...31,614,487
Ensembl chr19:31,524,671...31,614,246
JBrowse link
G Ift122 intraflagellar transport 122 ISO MGI:MGI:3578529|MGI:MGI:95728 (MGI:MGI:4888042|PMID:21209331), (MGI:MGI:6094959|PMID:28778798) RGD PMID:21209331, PMID:28778798 MGI:MGI:4888042, MGI:MGI:6094959 NCBI chr 4:147,756,574...147,826,983
Ensembl chr 4:147,756,553...147,826,997
JBrowse link
G Ift172 intraflagellar transport 172 ISO MGI:MGI:2682066 (MGI:MGI:6094959|PMID:28778798) RGD PMID:28778798 MGI:MGI:6094959 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Kctd11 potassium channel tetramerization domain containing 11 ISO (MGI:MGI:3603087|PMID:16148242) RGD PMID:16148242 MGI:MGI:3603087 NCBI chr10:56,489,552...56,491,715
Ensembl chr10:56,489,552...56,491,715
JBrowse link
G Kctd21 potassium channel tetramerization domain containing 21 ISO
IEA
(PMID:21472142)
GO_REF:0000107
RGD
Ensembl
PMID:21472142 GO_REF:0000107 NCBI chr 1:162,307,746...162,325,284
Ensembl chr 1:162,320,730...162,325,013
JBrowse link
G Kctd6 potassium channel tetramerization domain containing 6 ISO (PMID:21472142) RGD PMID:21472142 NCBI chr15:18,484,607...18,493,188
Ensembl chr15:18,484,510...18,493,366
JBrowse link
G Kif7 kinesin family member 7 ISO (MGI:MGI:4355635|PMID:19666503), (MGI:MGI:4357736|PMID:19549984), (MGI:MGI:4359116|PMID:19592253) RGD PMID:19549984, PMID:19592253, PMID:19666503 MGI:MGI:4355635, MGI:MGI:4357736, MGI:MGI:4359116 NCBI chr 1:141,434,183...141,452,592
Ensembl chr 1:141,434,625...141,451,075
JBrowse link
G Megf8 multiple EGF-like-domains 8 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:6111022|PMID:29290584)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29290584 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6111022 NCBI chr 1:82,184,671...82,234,045
Ensembl chr 1:82,185,034...82,234,045
JBrowse link
G Mgrn1 mahogunin ring finger 1 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6111022|PMID:29290584)
UniProt
Ensembl
RGD
PMID:29290584 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6111022 NCBI chr10:10,832,573...10,881,999
Ensembl chr10:10,833,519...10,881,977
JBrowse link
G Mosmo modulator of smoothened ISO
IBA
(MGI:MGI:6111022|PMID:29290584)
PMID:21873635
RGD PMID:29290584, PMID:21873635 MGI:MGI:6111022, RGD:13792537 NCBI chr 1:190,604,613...190,671,906
Ensembl chr 1:190,666,149...190,671,228
JBrowse link
G Ptch1 patched 1 ISO UniProtKB:Q62226 (MGI:MGI:5306540|PMID:21931618) RGD PMID:21931618 MGI:MGI:5306540 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Rack1 receptor for activated C kinase 1 ISO (PMID:32467643) RGD PMID:32467643 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IEA
MGI:MGI:1931018|MGI:MGI:3574761 (MGI:MGI:3703460|PMID:17257418)
GO_REF:0000107
RGD
Ensembl
PMID:17257418 GO_REF:0000107, MGI:MGI:3703460 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO
IEA
MGI:MGI:2176465 (MGI:MGI:3656469|PMID:15668330)
GO_REF:0000107
RGD
Ensembl
PMID:15668330 GO_REF:0000107, MGI:MGI:3656469 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sall1 spalt-like transcription factor 1 ISO MGI:MGI:109295 (MGI:MGI:3829797|PMID:19168674) RGD PMID:19168674 MGI:MGI:3829797 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
G Sall3 spalt-like transcription factor 3 ISO MGI:MGI:1889585 (MGI:MGI:3829797|PMID:19168674) RGD PMID:19168674 MGI:MGI:3829797 NCBI chr18:77,572,200...77,591,710
Ensembl chr18:77,573,702...77,579,969
JBrowse link
G Serpine2 serpin family E member 2 ISO
IEA
MGI:MGI:98297 (MGI:MGI:3709698|PMID:17409116)
GO_REF:0000107
RGD
Ensembl
PMID:17409116 GO_REF:0000107, MGI:MGI:3709698 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (PMID:27234298), (PMID:28965847)
MGI:MGI:3619046 (MGI:MGI:1346364|PMID:10531011), (MGI:MGI:3616741|PMID:16459298), (MGI:MGI:3804352|PMID:18488998), (MGI:MGI:5789064|PMID:27234298)
RGD PMID:10531011, PMID:16459298, PMID:18488998, PMID:27234298, PMID:28965847 MGI:MGI:1346364, MGI:MGI:3616741, MGI:MGI:3804352, MGI:MGI:5789064 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
G Tulp3 TUB like protein 3 ISO (PMID:20889716)
MGI:MGI:2388066|MGI:MGI:3664273 (MGI:MGI:3841513|PMID:19223390), (MGI:MGI:3844764|PMID:19334287)
RGD PMID:19223390, PMID:19334287, PMID:20889716 MGI:MGI:3841513, MGI:MGI:3844764 NCBI chr 4:161,636,084...161,677,807
Ensembl chr 4:161,637,892...161,658,519
JBrowse link
G Ulk3 unc-51 like kinase 3 ISO
ISS
(PMID:20643644)
GO_REF:0000024
RGD
UniProt
PMID:20643644 GO_REF:0000024 NCBI chr 8:62,368,548...62,375,229
Ensembl chr 8:62,368,998...62,374,504
JBrowse link
G Vcp valosin-containing protein ISO (PMID:23747190) RGD PMID:23747190 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Wnt7b Wnt family member 7B ISO (MGI:MGI:1855801|PMID:10781055) RGD PMID:10781055 MGI:MGI:1855801 NCBI chr 7:126,423,418...126,465,724
Ensembl chr 7:126,420,656...126,465,723
JBrowse link
negative regulation of hh target transcription factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:6220772|PMID:30111653)
UniProt
RGD
PMID:30111653 GO_REF:0000024, MGI:MGI:6220772 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk20 cyclin-dependent kinase 20 ISO
IEA
MGI:MGI:108075|MGI:MGI:99833 (MGI:MGI:5912686|PMID:28817564)
GO_REF:0000107
RGD
Ensembl
PMID:28817564 GO_REF:0000107, MGI:MGI:5912686 NCBI chr17:1,935,900...1,942,867
Ensembl chr17:1,936,163...1,942,865
JBrowse link
G Gpr161 G protein-coupled receptor 161 ISO (MGI:MGI:5468365|PMID:23332756) RGD PMID:23332756 MGI:MGI:5468365 NCBI chr13:83,530,389...83,576,117
Ensembl chr13:83,531,018...83,571,505
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO
IEA
MGI:MGI:97760 (MGI:MGI:5308523|PMID:22007132)
GO_REF:0000107
RGD
Ensembl
PMID:22007132 GO_REF:0000107, MGI:MGI:5308523 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO MGI:MGI:97592 (MGI:MGI:5308523|PMID:22007132) RGD PMID:22007132 MGI:MGI:5308523 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:MGI:4840420 (MGI:MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 ISO MGI:MGI:4129326 (MGI:MGI:5298450|PMID:21945076) RGD PMID:21945076 MGI:MGI:5298450 NCBI chr 9:98,621,499...98,658,223
Ensembl chr 9:98,621,506...98,656,901
JBrowse link
G Tulp3 TUB like protein 3 ISO MGI:MGI:2388066 (MGI:MGI:3844764|PMID:19334287) RGD PMID:19334287 MGI:MGI:3844764 NCBI chr 4:161,636,084...161,677,807
Ensembl chr 4:161,637,892...161,658,519
JBrowse link
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ift122 intraflagellar transport 122 ISO (MGI:MGI:4888042|PMID:21209331) RGD PMID:21209331 MGI:MGI:4888042 NCBI chr 4:147,756,574...147,826,983
Ensembl chr 4:147,756,553...147,826,997
JBrowse link
G Rfx4 regulatory factor X4 ISO
IBA
MGI:MGI:3799278 (MGI:MGI:5430880|PMID:19887680)
PMID:21873635
RGD PMID:19887680, PMID:21873635 MGI:MGI:5430880, RGD:13792537 NCBI chr 7:25,831,358...25,909,976
Ensembl chr 7:25,808,419...25,907,849
JBrowse link
G Tulp3 TUB like protein 3 ISO MGI:MGI:2388066 (MGI:MGI:3841503|PMID:19286674) RGD PMID:19286674 MGI:MGI:3841503 NCBI chr 4:161,636,084...161,677,807
Ensembl chr 4:161,637,892...161,658,519
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      signal transduction 7016
        negative regulation of signal transduction 1243
          negative regulation of smoothened signaling pathway 38
            negative regulation of hh target transcription factor activity 1
            negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 7
            negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of cellular process 12563
          signal transduction 7016
            cell surface receptor signaling pathway 2783
              smoothened signaling pathway 160
                regulation of smoothened signaling pathway 94
                  negative regulation of smoothened signaling pathway 38
                    negative regulation of hh target transcription factor activity 1
                    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 7
                    negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.