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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of smoothened signaling pathway
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Accession:GO:0045879 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
Synonyms:exact_synonym: down regulation of smoothened signaling pathway;   downregulation of smoothened signaling pathway;   negative regulation of hedgehog signaling pathway;   negative regulation of hh signaling pathway;   negative regulation of smoothened signalling pathway
 narrow_synonym: inhibition of smoothened signaling pathway;   negative regulation of smoothened by patched
 related_synonym: negative regulation of smoothened activity;   negative regulation of smoothened receptor activity by patched
 alt_id: GO:0045877


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negative regulation of smoothened signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd3e CD3e molecule acts_upstream_of_or_within ISO (MGI:1888832|PMID:10981962) RGD PMID:10981962 MGI:1888832 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:1931521 (MGI:1307032|PMID:9811582) RGD PMID:9811582 MGI:1307032 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Gas1 growth arrest-specific 1 acts_upstream_of_or_within ISO (MGI:2150860|PMID:11572986) RGD PMID:11572986 MGI:2150860 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:1932386 (MGI:6094959|PMID:28778798) RGD PMID:28778798 MGI:6094959 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:4355451|PMID:19667090) RGD PMID:19667090 MGI:4355451 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Glis2 GLIS family zinc finger 2 involved_in ISO (MGI:5292436|PMID:21816948) RGD PMID:21816948 MGI:5292436 NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578
JBrowse link
G Gpc3 glypican 3 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:2159356|MGI:96533 (MGI:3790551|PMID:18477453), (MGI:4430672|PMID:19590577)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:18477453 PMID:19590577 GO_REF:0000024 GO_REF:0000107 MGI:3790551 MGI:4430672 NCBI chr  X:131,868,983...132,236,837
Ensembl chr  X:131,868,990...132,236,798
JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5439169 (MGI:5512663|PMID:24062445)
Ensembl
RGD
PMID:24062445 GO_REF:0000107 MGI:5512663 NCBI chr13:46,598,574...46,605,421
Ensembl chr13:46,598,578...46,605,421
JBrowse link
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 involved_in ISO (PMID:31010679) RGD PMID:31010679 NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657
JBrowse link
G Hhip Hedgehog-interacting protein involved_in
acts_upstream_of_or_within
ISO (MGI:5284801|PMID:15294024)
MGI:2450891 (MGI:1333378|PMID:10050855), (MGI:2450020|PMID:12569124)
RGD PMID:10050855 PMID:12569124 PMID:15294024 MGI:1333378 MGI:2450020 MGI:5284801 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528
JBrowse link
G Ift122 intraflagellar transport 122 acts_upstream_of_or_within
involved_in
ISO MGI:3578529|MGI:95728 (MGI:6094959|PMID:28778798)
(MGI:4888042|PMID:21209331)
RGD PMID:21209331 PMID:28778798 MGI:4888042 MGI:6094959 NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458
JBrowse link
G Ift172 intraflagellar transport 172 acts_upstream_of_or_within ISO MGI:2682066 (MGI:6094959|PMID:28778798) RGD PMID:28778798 MGI:6094959 NCBI chr 6:25,081,933...25,121,271 JBrowse link
G Kctd11 potassium channel tetramerization domain containing 11 acts_upstream_of_or_within ISO (MGI:3603087|PMID:16148242) RGD PMID:16148242 MGI:3603087 NCBI chr10:54,602,575...54,604,738
Ensembl chr10:54,599,754...54,604,760
JBrowse link
G Kctd21 potassium channel tetramerization domain containing 21 involved_in ISO (PMID:21472142) RGD PMID:21472142 NCBI chr 1:151,650,074...151,669,775
Ensembl chr 1:151,650,104...151,667,645
JBrowse link
G Kctd6 potassium channel tetramerization domain containing 6 involved_in ISO (PMID:21472142) RGD PMID:21472142 NCBI chr15:16,695,297...16,712,460
Ensembl chr15:16,695,297...16,698,699
JBrowse link
G Kif7 kinesin family member 7 involved_in ISO (MGI:4355635|PMID:19666503), (MGI:4357736|PMID:19549984), (MGI:4359116|PMID:19592253) RGD PMID:19549984 PMID:19592253 PMID:19666503 MGI:4355635 MGI:4357736 MGI:4359116 NCBI chr 1:133,639,487...133,658,539
Ensembl chr 1:133,640,065...133,658,576
JBrowse link
G Megf8 multiple EGF-like-domains 8 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6111022|PMID:29290584)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:29290584 GO_REF:0000024 GO_REF:0000107 MGI:6111022 NCBI chr 1:80,902,236...80,951,614
Ensembl chr 1:80,902,574...80,951,613
JBrowse link
G Mgrn1 mahogunin ring finger 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6111022|PMID:29290584)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29290584 GO_REF:0000024 GO_REF:0000107 MGI:6111022 NCBI chr10:10,638,881...10,688,332
Ensembl chr10:10,638,880...10,688,315
JBrowse link
G Mosmo modulator of smoothened involved_in IBA
ISO
PMID:21873635
(MGI:6111022|PMID:29290584)
RGD PMID:29290584 PMID:21873635 MGI:6111022, RGD:13792537 NCBI chr 1:175,217,658...175,288,521 JBrowse link
G Ptch1 patched 1 involved_in ISO UniProtKB:Q62226 (MGI:5306540|PMID:21931618) RGD PMID:21931618 MGI:5306540 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:32467643) RGD PMID:32467643 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1931018|MGI:3574761 (MGI:3703460|PMID:17257418)
Ensembl
RGD
PMID:17257418 GO_REF:0000107 MGI:3703460 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Runx2 RUNX family transcription factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2176465 (MGI:3656469|PMID:15668330)
Ensembl
RGD
PMID:15668330 GO_REF:0000107 MGI:3656469 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sall1 spalt-like transcription factor 1 acts_upstream_of_or_within ISO MGI:109295 (MGI:3829797|PMID:19168674) RGD PMID:19168674 MGI:3829797 NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705
JBrowse link
G Sall3 spalt-like transcription factor 3 acts_upstream_of_or_within ISO MGI:1889585 (MGI:3829797|PMID:19168674) RGD PMID:19168674 MGI:3829797 NCBI chr18:74,406,058...74,425,754
Ensembl chr18:74,407,560...74,426,789
JBrowse link
G Serpine2 serpin family E member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:98297 (MGI:3709698|PMID:17409116)
Ensembl
RGD
PMID:17409116 GO_REF:0000107 MGI:3709698 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within
ISO (PMID:27234298), (PMID:28965847)
(MGI:5789064|PMID:27234298)
(MGI:1346364|PMID:10531011)
MGI:3619046 (MGI:3616741|PMID:16459298), (MGI:3804352|PMID:18488998)
RGD PMID:10531011 PMID:16459298 PMID:18488998 PMID:27234298 PMID:28965847 MGI:1346364 MGI:3616741 MGI:3804352 MGI:5789064 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
JBrowse link
G Tulp3 TUB like protein 3 involved_in
acts_upstream_of_or_within
ISO (PMID:20889716)
MGI:2388066|MGI:3664273 (MGI:3841513|PMID:19223390), (MGI:3844764|PMID:19334287)
RGD PMID:19223390 PMID:19334287 PMID:20889716 MGI:3841513 MGI:3844764 NCBI chr 4:161,590,478...161,632,514
Ensembl chr 4:161,590,479...161,632,149
JBrowse link
G Ulk3 unc-51 like kinase 3 involved_in ISO
ISS
(PMID:20643644)
GO_REF:0000024
RGD
UniProt
PMID:20643644 GO_REF:0000024 NCBI chr 8:57,992,396...58,000,220
Ensembl chr 8:57,992,723...57,999,467
JBrowse link
G Vcp valosin-containing protein involved_in ISO (PMID:23747190) RGD PMID:23747190 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Wnt7b Wnt family member 7B acts_upstream_of_or_within ISO (MGI:1855801|PMID:10781055) RGD PMID:10781055 MGI:1855801 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
negative regulation of hh target transcription factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6220772|PMID:30111653)
UniProt
RGD
PMID:30111653 GO_REF:0000024 MGI:6220772 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk20 cyclin-dependent kinase 20 acts_upstream_of_or_within ISO MGI:108075|MGI:99833 (MGI:5912686|PMID:28817564) RGD PMID:28817564 MGI:5912686 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826
JBrowse link
G Gpr161 G protein-coupled receptor 161 involved_in ISO (MGI:5468365|PMID:23332756) RGD PMID:23332756 MGI:5468365 NCBI chr13:77,578,257...77,623,661
Ensembl chr13:77,577,739...77,619,613
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97760 (MGI:5308523|PMID:22007132)
Ensembl
RGD
PMID:22007132 GO_REF:0000107 MGI:5308523 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta acts_upstream_of_or_within ISO MGI:97592 (MGI:5308523|PMID:22007132) RGD PMID:22007132 MGI:5308523 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 acts_upstream_of_or_within ISO MGI:4129326 (MGI:5298450|PMID:21945076) RGD PMID:21945076 MGI:5298450 NCBI chr 9:92,073,622...92,110,427
Ensembl chr 9:92,073,640...92,108,977
JBrowse link
G Tulp3 TUB like protein 3 acts_upstream_of_or_within ISO MGI:2388066 (MGI:3844764|PMID:19334287) RGD PMID:19334287 MGI:3844764 NCBI chr 4:161,590,478...161,632,514
Ensembl chr 4:161,590,479...161,632,149
JBrowse link
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ift122 intraflagellar transport 122 involved_in ISO (MGI:4888042|PMID:21209331) RGD PMID:21209331 MGI:4888042 NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458
JBrowse link
G Rfx4 regulatory factor X4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3799278 (MGI:5430880|PMID:19887680)
RGD PMID:19887680 PMID:21873635 MGI:5430880, RGD:13792537 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967
JBrowse link
G Tulp3 TUB like protein 3 acts_upstream_of_or_within ISO MGI:2388066 (MGI:3841503|PMID:19286674) RGD PMID:19286674 MGI:3841503 NCBI chr 4:161,590,478...161,632,514
Ensembl chr 4:161,590,479...161,632,149
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      signal transduction 6882
        negative regulation of signal transduction 1264
          negative regulation of smoothened signaling pathway 38
            negative regulation of hh target transcription factor activity 1
            negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 7
            negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12228
          signal transduction 6882
            cell surface receptor signaling pathway 2779
              smoothened signaling pathway 158
                regulation of smoothened signaling pathway 94
                  negative regulation of smoothened signaling pathway 38
                    negative regulation of hh target transcription factor activity 1
                    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 7
                    negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
paths to the root