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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of ossification
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Accession:GO:0045778 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: positive regulation of bone biosynthesis;   positive regulation of bone formation;   up regulation of ossification;   upregulation of ossification
 narrow_synonym: activation of ossification;   stimulation of ossification


show annotations for term's descendants           Sort by:
positive regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO (MGI:3575204|PMID:15820682), (MGI:4948784|PMID:21324897)
(PMID:9213002)		 RGD PMID:9213002 PMID:15820682 PMID:21324897 MGI:3575204 MGI:4948784 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within IMP
IDA
ISO		 PMID:7911662
(PMID:14749725)
(MGI:63654|PMID:8358941)		 RGD PMID:8358941 PMID:14749725 PMID:17112416 PMID:7911662 MGI:63654, RGD:1643600, RGD:632977 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:2429424|PMID:12441304) RGD PMID:12441304 MGI:2429424 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:2148538 (MGI:3653805|PMID:15537449) RGD PMID:15537449 MGI:3653805 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2673982 (MGI:3055483|PMID:15469977) RGD PMID:15469977 MGI:3055483 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Nell1 neural EGFL like 1 IMP RGD PMID:19493425 RGD:2314454 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860 		JBrowse link
G Nipbl NIPBL, cohesin loading factor acts_upstream_of_or_within ISO MGI:4332250 (MGI:4367301|PMID:19763162) RGD PMID:19763162 MGI:4367301 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:18257653 RGD:2304114 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:3616954|PMID:16269410), (MGI:3797675|PMID:18519738) RGD PMID:16269410 PMID:18519738 MGI:3616954 MGI:3797675 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:14751573 PMID:17106877 RGD:10043372, RGD:10045950 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Pth parathyroid hormone IDA RGD PMID:15758479 RGD:7207452 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Ptn pleiotrophin involved_in IMP PMID:9817766 UniProt PMID:9817766 RGD:14397563 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6414736|PMID:29644115)		 UniProt
RGD		 PMID:29644115 GO_REF:0000024 MGI:6414736 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Runx2 RUNX family transcription factor 2 IMP RGD PMID:11784711 RGD:1601657 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 acts_upstream_of_or_within ISO MGI:5698367 (MGI:5698232|PMID:25639508) RGD PMID:25639508 MGI:5698232 NCBI chr 1:163,831,876...163,899,925
Ensembl chr 1:163,832,015...163,899,393 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase IMP RGD PMID:30746871 RGD:151665130 NCBI chr 8:110,511,808...110,597,489
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3052265|PMID:15254231)
(PMID:20626275)		 UniProt
RGD		 PMID:15254231 PMID:20626275 GO_REF:0000024 MGI:3052265 NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:17204323 RGD:2304342 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17204323 RGD:2304342 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (PMID:17401695) RGD PMID:17401695 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Thrb thyroid hormone receptor beta IDA RGD PMID:15647824 RGD:1601663 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tob2 transducer of ERBB2, 2 acts_upstream_of_or_within ISO MGI:3789484 (MGI:3785228|PMID:18358842) RGD PMID:18358842 MGI:3785228 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688 		JBrowse link
G Wnt10b Wnt family member 10B acts_upstream_of_or_within ISO MGI:3582610|MGI:98578 (MGI:3574150|PMID:15728361), (MGI:3829542|PMID:17708715), (MGI:4358631|PMID:19723499) RGD PMID:15728361 PMID:17708715 PMID:19723499 MGI:3574150 MGI:3829542 MGI:4358631 NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO (PMID:20032469) RGD PMID:20032469 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21547890)		 UniProt
RGD		 PMID:21547890 GO_REF:0000024 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
positive regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Acvr2a activin A receptor type 2A involved_in IEA
ISO		 GO_REF:0000107
(PMID:18436533)		 Ensembl
RGD		 PMID:18436533 GO_REF:0000107 NCBI chr 3:33,204,961...33,292,673
Ensembl chr 3:33,205,523...33,289,968 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 involved_in ISO (MGI:6211994|PMID:22419726) RGD PMID:22419726 MGI:6211994 NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688 		JBrowse link
G Adrb2 adrenoceptor beta 2 acts_upstream_of_or_within ISO MGI:1859675 (MGI:3575849|PMID:15724149) RGD PMID:15724149 MGI:3575849 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6393219|PMID:24906289)		 UniProt
Ensembl
RGD		 PMID:24906289 GO_REF:0000024 GO_REF:0000107 MGI:6393219 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ano6 anoctamin 6 involved_in ISO (PMID:25589784)
(MGI:5634871|PMID:25589784)		 RGD PMID:25589784 MGI:5634871 NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5780494|PMID:26392310)		 UniProt
RGD		 PMID:26392310 GO_REF:0000024 MGI:5780494 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Atraid all-trans retinoic acid-induced differentiation factor involved_in ISO (PMID:21723284) RGD PMID:21723284 NCBI chr 6:25,315,236...25,319,804 JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5009350|PMID:20675382)
(PMID:18436533), (PMID:20576608)		 UniProt
RGD		 PMID:18436533 PMID:20576608 PMID:20675382 GO_REF:0000024 MGI:5009350 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in		 IDA
ISO
ISS
IEA		 (PMID:14749725)
GO_REF:0000024
(PMID:14749725), (PMID:18436533)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:14749725 PMID:18436533 PMID:15352071 GO_REF:0000024 GO_REF:0000107, RGD:9068399 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Ccn1 cellular communication network factor 1 involved_in ISO (PMID:20675382) RGD PMID:20675382 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cd276 Cd276 molecule acts_upstream_of_or_within ISO MGI:3033707 (MGI:3052626|PMID:15317945) RGD PMID:15317945 MGI:3052626 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:18434589 RGD:151665814 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase acts_upstream_of_or_within ISO (MGI:3715055|PMID:17369251), (MGI:5427766|PMID:22615579) RGD PMID:17369251 PMID:22615579 MGI:3715055 MGI:5427766 NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543 		JBrowse link
G Fbn2 fibrillin 2 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr18:51,499,737...51,703,976
Ensembl chr18:51,499,737...51,703,976 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:2135670 (MGI:4437389|PMID:20053668) RGD PMID:20053668 MGI:4437389 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fzd9 frizzled class receptor 9 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943600|PMID:21402791)		 UniProt
RGD		 PMID:21402791 GO_REF:0000024 MGI:4943600 NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398 		JBrowse link
G Gpm6b glycoprotein m6b involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21638316)		 UniProt
Ensembl
RGD		 PMID:21638316 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (MGI:4943600|PMID:21402791) RGD PMID:21402791 MGI:4943600 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Kl Klotho involved_in ISO
IEA		 (PMID:12110410)
GO_REF:0000107		 RGD
Ensembl		 PMID:12110410 GO_REF:0000107 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:5285459|PMID:21652706)		 UniProt
RGD		 PMID:21652706 GO_REF:0000024 MGI:5285459 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mia3 MIA SH3 domain ER export factor 3 acts_upstream_of_or_within ISO MGI:5007248 (MGI:5008683|PMID:21606205) RGD PMID:21606205 MGI:5008683 NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972 		JBrowse link
G Nell1 neural EGFL like 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21723284)		 UniProt
Ensembl
RGD		 PMID:21723284 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860 		JBrowse link
G Osr1 odd-skipped related transcription factor 1 involved_in ISO UniProtKB:Q91ZD1 (MGI:4950000|PMID:21262216) RGD PMID:21262216 MGI:4950000 NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817 		JBrowse link
G Osr2 odd-skipped related transciption factor 2 involved_in ISO UniProtKB:Q9WVG7 (MGI:4950000|PMID:21262216) RGD PMID:21262216 MGI:4950000 NCBI chr 7:66,487,841...66,495,003
Ensembl chr 7:66,487,839...66,495,224 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:2667237|PMID:12677010), (MGI:3797675|PMID:18519738) RGD PMID:12677010 PMID:18519738 MGI:2667237 MGI:3797675 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:3813934|PMID:19097194) RGD PMID:19097194 MGI:3813934 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IEP RGD PMID:10807497 RGD:1642474 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pth parathyroid hormone involved_in IDA
ISO		 (PMID:17696759) RGD PMID:17696759 PMID:15758479 PMID:22445539 RGD:7207452, RGD:7242906 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Ptn pleiotrophin involved_in ISS
ISO		 GO_REF:0000024
(MGI:6294181|PMID:19442624)		 UniProt
RGD		 PMID:19442624 GO_REF:0000024 MGI:6294181 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:25589784) RGD PMID:25589784 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Smad3 SMAD family member 3 IDA rat gene expressed in mouse osteoblastic cell line MC3T3-E1; TGF-beta down-regulates this activity RGD PMID:12096832 RGD:727387 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tent5a terminal nucleotidyltransferase 5A involved_in ISO (MGI:6717031|PMID:33882302) RGD PMID:33882302 MGI:6717031 NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045 		JBrowse link
G Tfap2a transcription factor AP-2 alpha involved_in ISO
ISS		 (PMID:19578371)
GO_REF:0000024		 RGD
UniProt		 PMID:19578371 GO_REF:0000024 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (PMID:17401695) RGD PMID:17401695 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (PMID:17401695) RGD PMID:17401695 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO
IBA		 (PMID:20025746)
(MGI:4418582|PMID:20025746), (MGI:5700277|PMID:26207632)
PMID:21873635		 RGD PMID:20025746 PMID:26207632 PMID:21873635 MGI:4418582 MGI:5700277, RGD:13792537 NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689 		JBrowse link
G Wnt10b Wnt family member 10B acts_upstream_of_or_within ISO (MGI:3574150|PMID:15728361) RGD PMID:15728361 MGI:3574150 NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:17720811)
GO_REF:0000107		 RGD
Ensembl		 PMID:17720811 GO_REF:0000107 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
positive regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:5291888|PMID:21784188) RGD PMID:21784188 MGI:5291888 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO MGI:3840841 (MGI:5514358|PMID:21490954) RGD PMID:21490954 MGI:5514358 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO
ISS		 (PMID:16433617)
GO_REF:0000024		 RGD
UniProt		 PMID:16433617 GO_REF:0000024 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    multicellular organismal process 9260
      ossification 467
        positive regulation of ossification 64
          positive regulation of bone mineralization + 47
Path 2
Term Annotations click to browse term
  biological_process 19898
    biological regulation 13573
      regulation of biological process 13161
        regulation of multicellular organismal process 3380
          regulation of ossification 143
            positive regulation of ossification 64
              positive regulation of bone mineralization + 47
paths to the root