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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of ossification
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Accession:GO:0045778 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: positive regulation of bone biosynthesis;   positive regulation of bone formation;   up regulation of ossification;   upregulation of ossification
 narrow_synonym: activation of ossification;   stimulation of ossification

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positive regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:9213002)
(MGI:3575204|PMID:15820682), (MGI:4948784|PMID:21324897)		 RGD PMID:9213002 PMID:15820682 PMID:21324897 MGI:3575204 MGI:4948784 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IMP
IDA
ISO		 PMID:7911662
(PMID:14749725)
(MGI:63654|PMID:8358941)		 RGD PMID:8358941 PMID:14749725, PMID:17112416, PMID:7911662, PMID:7911662 MGI:63654, RGD:1643600, RGD:632977, RGD:632977 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO (MGI:2429424|PMID:12441304) RGD PMID:12441304 MGI:2429424 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494 		JBrowse link
G Calca calcitonin-related polypeptide alpha ISO MGI:2148538 (MGI:3653805|PMID:15537449) RGD PMID:15537449 MGI:3653805 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Lrp6 LDL receptor related protein 6 ISO MGI:2673982 (MGI:3055483|PMID:15469977) RGD PMID:15469977 MGI:3055483 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751 		JBrowse link
G Nell1 neural EGFL like 1 IMP RGD PMID:19493425 RGD:2314454 NCBI chr 1:105,348,577...106,218,970
Ensembl chr 1:105,349,069...106,218,958 		JBrowse link
G Nipbl NIPBL, cohesin loading factor ISO MGI:4332250 (MGI:4367301|PMID:19763162) RGD PMID:19763162 MGI:4367301 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:18257653 RGD:2304114 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO MGI:2386080 (MGI:3616954|PMID:16269410), (MGI:3797675|PMID:18519738) RGD PMID:16269410 PMID:18519738 MGI:3616954 MGI:3797675 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:14751573, PMID:17106877 RGD:10043372, RGD:10045950 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Pth parathyroid hormone IDA RGD PMID:15758479 RGD:7207452 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Ptn pleiotrophin involved_in IMP PMID:9817766 UniProt PMID:9817766, PMID:9817766 RGD:14397563, RGD:14397563 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6414736|PMID:29644115)		 UniProt
RGD		 PMID:29644115 GO_REF:0000024 MGI:6414736 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999 		JBrowse link
G Runx2 RUNX family transcription factor 2 IMP RGD PMID:11784711 RGD:1601657 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 ISO MGI:5698367 (MGI:5698232|PMID:25639508) RGD PMID:25639508 MGI:5698232 NCBI chr 1:174,428,056...174,495,356
Ensembl chr 1:174,428,699...174,495,258 		JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISO
ISS		 (PMID:20626275)
GO_REF:0000024
(MGI:3052265|PMID:15254231)		 RGD
UniProt		 PMID:15254231 PMID:20626275 GO_REF:0000024 MGI:3052265 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:17204323 RGD:2304342 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17204323 RGD:2304342 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO
ISS		 (PMID:17401695)
GO_REF:0000024		 RGD
AgBase		 PMID:17401695 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Thrb thyroid hormone receptor beta IDA RGD PMID:15647824 RGD:1601663 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tob2 transducer of ERBB2, 2 ISO MGI:3789484 (MGI:3785228|PMID:18358842) RGD PMID:18358842 MGI:3785228 NCBI chr 7:123,079,520...123,088,240
Ensembl chr 7:123,079,537...123,088,279 		JBrowse link
G Wnt10b Wnt family member 10B ISO MGI:3582610|MGI:98578 (MGI:3574150|PMID:15728361), (MGI:3829542|PMID:17708715), (MGI:4358631|PMID:19723499) RGD PMID:15728361 PMID:17708715 PMID:19723499 MGI:3574150 MGI:3829542 MGI:4358631 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 (PMID:20032469)
GO_REF:0000107		 RGD
Ensembl		 PMID:20032469 GO_REF:0000107 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in ISO
ISS		 (PMID:21547890)
GO_REF:0000024		 RGD
UniProt		 PMID:21547890 GO_REF:0000024 NCBI chr 8:52,980,226...53,146,765
Ensembl chr 8:52,985,313...53,146,953 		JBrowse link
positive regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO
IEA		 (PMID:18436533)
GO_REF:0000107		 RGD
Ensembl		 PMID:18436533 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930 		JBrowse link
G Acvr2a activin A receptor type 2A involved_in ISO
IEA		 (PMID:18436533)
GO_REF:0000107		 RGD
Ensembl		 PMID:18436533 GO_REF:0000107 NCBI chr 3:32,947,901...33,034,598
Ensembl chr 3:32,947,378...33,034,282 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO
IEA		 (PMID:18436533)
GO_REF:0000107		 RGD
Ensembl		 PMID:18436533 GO_REF:0000107 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746 		JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 ISO (MGI:6211994|PMID:22419726) RGD PMID:22419726 MGI:6211994 NCBI chr 2:8,926,843...9,504,455
Ensembl chr 2:8,926,850...9,504,134 		JBrowse link
G Adrb2 adrenoceptor beta 2 IEA
ISO		 GO_REF:0000107
MGI:1859675 (MGI:3575849|PMID:15724149)		 Ensembl
RGD		 PMID:15724149 GO_REF:0000107 MGI:3575849 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6393219|PMID:24906289)		 UniProt
Ensembl
RGD		 PMID:24906289 GO_REF:0000024 GO_REF:0000107 MGI:6393219 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Ano6 anoctamin 6 involved_in ISO (PMID:25589784)
(MGI:5634871|PMID:25589784)		 RGD PMID:25589784 MGI:5634871 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5780494|PMID:26392310)		 UniProt
RGD		 PMID:26392310 GO_REF:0000024 MGI:5780494 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579 		JBrowse link
G Atraid all-trans retinoic acid-induced differentiation factor involved_in ISO (PMID:21723284) RGD PMID:21723284 NCBI chr 6:26,680,628...26,685,185
Ensembl chr 6:26,680,598...26,685,235 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18436533), (PMID:20576608)
(MGI:5009350|PMID:20675382)		 UniProt
RGD		 PMID:18436533 PMID:20576608 PMID:20675382 GO_REF:0000024 MGI:5009350 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IDA
ISS
ISO
IEA		 GO_REF:0000024
(PMID:14749725), (PMID:18436533)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:14749725 PMID:18436533, PMID:15352071 GO_REF:0000024 GO_REF:0000107, RGD:9068399 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18436533) RGD PMID:18436533 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494 		JBrowse link
G Ccn1 cellular communication network factor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20675382)		 Ensembl
RGD		 PMID:20675382 GO_REF:0000107 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Cd276 Cd276 molecule ISO MGI:3033707 (MGI:3052626|PMID:15317945) RGD PMID:15317945 MGI:3052626 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269 		JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase ISO (MGI:3715055|PMID:17369251), (MGI:5427766|PMID:22615579) RGD PMID:17369251 PMID:22615579 MGI:3715055 MGI:5427766 NCBI chr12:17,913,771...17,972,733
Ensembl chr12:17,913,767...17,972,737 		JBrowse link
G Fbn2 fibrillin 2 ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO MGI:2135670 (MGI:4437389|PMID:20053668) RGD PMID:20053668 MGI:4437389 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fzd9 frizzled class receptor 9 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943600|PMID:21402791)		 UniProt
RGD		 PMID:21402791 GO_REF:0000024 MGI:4943600 NCBI chr12:24,473,981...24,476,295
Ensembl chr12:24,473,981...24,476,295 		JBrowse link
G Gpm6b glycoprotein m6b involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21638316)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:21638316 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier ISO (MGI:4943600|PMID:21402791) RGD PMID:21402791 MGI:4943600 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248 		JBrowse link
G Kl Klotho involved_in IEA
ISO		 GO_REF:0000107
(PMID:12110410)		 Ensembl
RGD		 PMID:12110410 GO_REF:0000107 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:5285459|PMID:21652706)		 UniProt
RGD		 PMID:21652706 GO_REF:0000024 MGI:5285459 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787 		JBrowse link
G Mia3 MIA SH3 domain ER export factor 3 ISO MGI:5007248 (MGI:5008683|PMID:21606205) RGD PMID:21606205 MGI:5008683 NCBI chr13:101,727,434...101,770,127
Ensembl chr13:101,727,935...101,761,541 		JBrowse link
G Nell1 neural EGFL like 1 involved_in ISO
ISS		 (PMID:21723284)
GO_REF:0000024		 RGD
UniProt		 PMID:21723284 GO_REF:0000024 NCBI chr 1:105,348,577...106,218,970
Ensembl chr 1:105,349,069...106,218,958 		JBrowse link
G Osr1 odd-skipped related transcription factor 1 ISO UniProtKB:Q91ZD1 (MGI:4950000|PMID:21262216) RGD PMID:21262216 MGI:4950000 NCBI chr 6:35,314,431...35,321,458
Ensembl chr 6:35,314,444...35,321,667 		JBrowse link
G Osr2 odd-skipped related transciption factor 2 ISO UniProtKB:Q9WVG7 (MGI:4950000|PMID:21262216) RGD PMID:21262216 MGI:4950000 NCBI chr 7:74,047,820...74,055,096
Ensembl chr 7:74,047,814...74,055,256 		JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO MGI:2386080 (MGI:2667237|PMID:12677010), (MGI:3797675|PMID:18519738) RGD PMID:12677010 PMID:18519738 MGI:2667237 MGI:3797675 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic ISO (MGI:3813934|PMID:19097194) RGD PMID:19097194 MGI:3813934 NCBI chr 6:6,427,657...6,436,974
Ensembl chr 6:6,427,657...6,436,974 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IEP RGD PMID:10807497 RGD:1642474 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Pth parathyroid hormone involved_in IDA
ISO		 (PMID:17696759) RGD PMID:17696759, PMID:15758479, PMID:22445539 RGD:7207452, RGD:7242906 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Ptn pleiotrophin involved_in ISS
ISO		 GO_REF:0000024
(MGI:6294181|PMID:19442624)		 UniProt
RGD		 PMID:19442624 GO_REF:0000024 MGI:6294181 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:25589784) RGD PMID:25589784 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Smad3 SMAD family member 3 IDA rat gene expressed in mouse osteoblastic cell line MC3T3-E1; TGF-beta down-regulates this activity RGD PMID:12096832 RGD:727387 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Tfap2a transcription factor AP-2 alpha involved_in ISO
ISS		 (PMID:19578371)
GO_REF:0000024		 RGD
UniProt		 PMID:19578371 GO_REF:0000024 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:17401695)
GO_REF:0000024		 RGD
AgBase		 PMID:17401695 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO
ISS		 (PMID:17401695)
GO_REF:0000024		 RGD
AgBase		 PMID:17401695 GO_REF:0000024 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO
IBA		 (PMID:20025746)
PMID:21873635
(MGI:4418582|PMID:20025746), (MGI:5700277|PMID:26207632)		 RGD PMID:20025746 PMID:26207632, PMID:21873635, PMID:21873635 MGI:4418582 MGI:5700277, RGD:13792537, RGD:13792537 NCBI chr12:48,598,498...48,605,704
Ensembl chr12:48,598,647...48,605,704 		JBrowse link
G Wnt10b Wnt family member 10B ISO (MGI:3574150|PMID:15728361) RGD PMID:15728361 MGI:3574150 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:17720811)
GO_REF:0000107		 RGD
Ensembl		 PMID:17720811 GO_REF:0000107 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579 		JBrowse link
positive regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 ISO (MGI:5291888|PMID:21784188) RGD PMID:21784188 MGI:5291888 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 ISO MGI:3840841 (MGI:5514358|PMID:21490954) RGD PMID:21490954 MGI:5514358 NCBI chr 6:27,835,346...27,919,285
Ensembl chr 6:27,887,797...27,915,563 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    multicellular organismal process 9072
      ossification 436
        positive regulation of ossification 61
          positive regulation of bone mineralization + 45
Path 2
Term Annotations click to browse term
  biological_process 20078
    biological regulation 13898
      regulation of biological process 13140
        regulation of multicellular organismal process 2925
          regulation of ossification 133
            positive regulation of ossification 61
              positive regulation of bone mineralization + 45
paths to the root