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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of blood pressure
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Accession:GO:0045776 term browser browse the term
Definition:Any process in which the force of blood traveling through the circulatory system is decreased.
Synonyms:exact_synonym: down regulation of blood pressure;   downregulation of blood pressure
 narrow_synonym: inhibition of blood pressure


show annotations for term's descendants           Sort by:
negative regulation of blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:8336820 RGD:1598530 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:6389242 (PMID:31575858)		 Ensembl
RGD		 PMID:31575858 GO_REF:0000107 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(PMID:17327472)		 UniProt
RGD		 PMID:17327472 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adm2 adrenomedullin 2 IMP RGD PMID:14615490 RGD:1304019 NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331 		JBrowse link
G Adora1 adenosine A1 receptor IMP RGD PMID:16690710 RGD:5129101 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Apln apelin involved_in IDA
IMP		 PMID:11359874 RGD
UniProt		 PMID:15486224 PMID:10617103 PMID:11359874 RGD:1576349, RGD:632247, RGD:12907555 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:16507603 PMID:15253105 RGD:1625747, RGD:1625759 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP RGD PMID:16507603 RGD:1625747 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within IMP
ISO		 (PMID:10642343)
MGI:3527257 (PMID:10642343), (PMID:15583078)		 RGD PMID:10642343 PMID:15583078 PMID:11230364 RGD:68890 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19295473 RGD:2314676 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875 (PMID:11566895) RGD PMID:11566895 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 acts_upstream_of_or_within ISO MGI:1857159 (PMID:9691085) RGD PMID:9691085 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd5 dopamine receptor D5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:109147|MGI:3528074 (PMID:12486173), (PMID:15598876)		 Ensembl
RGD		 PMID:12486173 PMID:15598876 GO_REF:0000107 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Ffar3 free fatty acid receptor 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23401498)		 UniProt
RGD		 PMID:23401498 GO_REF:0000024 NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IMP RGD PMID:12855421 RGD:1601283 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gja5 gap junction protein, alpha 5 IMP RGD PMID:18046320 RGD:7207467 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2150310 (PMID:23542788)		 Ensembl
RGD		 PMID:23542788 GO_REF:0000107 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Gnas GNAS complex locus IMP RGD PMID:21895632 RGD:5509797 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Guca2b guanylate cyclase activator 2B acts_upstream_of_or_within ISO MGI:2679505 (PMID:14561709) RGD PMID:14561709 NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 IDA RGD PMID:15962106 RGD:1599364 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hrh3 histamine receptor H3 IMP RGD PMID:9050021 RGD:1626409 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:18317593) RGD PMID:18317593 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Nos1 nitric oxide synthase 1 involved_in IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15331368 GO_REF:0000033, RGD:1598375 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of_or_within
involved_in		 ISO MGI:1857231 (PMID:23542788)
MGI:1857231 (PMID:23981445), (PMID:26536903)		 RGD PMID:23542788 PMID:23981445 PMID:26536903 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y IMP RGD PMID:15699473 RGD:1357410 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:10651151 RGD:9835014 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IMP RGD PMID:18562099 RGD:2304105 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:17045349 RGD:1642492 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:15967866 RGD:1580222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:9548392 PMID:3019921 RGD:10041048, RGD:10043185 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Rnls renalase, FAD-dependent amine oxidase involved_in ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823 		JBrowse link
G Rnpep arginyl aminopeptidase IMP RGD PMID:3001599 RGD:2325950 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Scpep1 serine carboxypeptidase 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P16675 (PMID:24586188)		 Ensembl
RGD		 PMID:24586188 GO_REF:0000107 NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850 		JBrowse link
G Snx5 sorting nexin 5 IMP RGD PMID:23195037 RGD:13508622 NCBI chr 3:131,621,875...131,641,127
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
G Ucn urocortin IDA RGD PMID:15604589 RGD:1642785 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:16531985 PMID:12217424 RGD:2306837, RGD:2306871 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Uts2r urotensin 2 receptor IMP RGD PMID:16531985 RGD:2306837 NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252 		JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:19412173 RGD:2315485 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857129|MGI:1857480 (PMID:16873728) RGD PMID:16873728 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO MGI:1857123|MGI:2158808|MGI:5050632 (PMID:10425188), (PMID:27217404) RGD PMID:10425188 PMID:27217404 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 acts_upstream_of_or_within
involved_in		 ISO MGI:1857123 (PMID:10425188) RGD PMID:10425188 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO MGI:2182739 (PMID:15998684) RGD PMID:15998684 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor involved_in ISO MGI:2158808 (PMID:27217404) RGD PMID:27217404 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mrgprd MAS related GPR family member D involved_in ISO MGI:5050632 (PMID:27217404) RGD PMID:27217404 NCBI chr 1:200,479,204...200,487,902
Ensembl chr 1:200,485,189...200,486,148 		JBrowse link
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:2445489 (PMID:11717154) RGD PMID:11717154 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2387663 (PMID:12093905)		 Ensembl
RGD		 PMID:12093905 GO_REF:0000107 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
negative regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor IDA RGD PMID:9597368 RGD:1625365 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Ahr aryl hydrocarbon receptor involved_in ISO (PMID:14644620) RGD PMID:14644620 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Apln apelin IDA RGD PMID:12798955 RGD:1626237 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Arhgap42 Rho GTPase activating protein 42 acts_upstream_of_or_within ISO MGI:1096342 (PMID:24335996) RGD PMID:24335996 NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3045473 (PMID:18317593) RGD PMID:18317593 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18364108) RGD PMID:18364108 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:22128087 RGD:6893560 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:7477349 RGD:70047 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29625592)		 UniProt
Ensembl
RGD		 PMID:29625592 GO_REF:0000024 GO_REF:0000107 NCBI chr13:46,598,574...46,605,421
Ensembl chr13:46,598,578...46,605,421 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (PMID:16166241) RGD PMID:16166241 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 acts_upstream_of_or_within ISO MGI:2155245 (PMID:23637138) RGD PMID:23637138 NCBI chr 1:84,525,613...84,533,948
Ensembl chr 1:84,525,590...84,534,677 		JBrowse link
G Kdr kinase insert domain receptor IGI RGD PMID:12052848 RGD:2292104 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3846431 (PMID:18524855) RGD PMID:18524855 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137 		JBrowse link
G Nppa natriuretic peptide A involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:2136863 GO_REF:0000033, RGD:7247720 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:8289999 PMID:21403100 GO_REF:0000033, RGD:7247315, RGD:5685657 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:22211865 RGD:9727449 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Prcp prolylcarboxypeptidase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:4123993 (PMID:21297000)		 GO_Central
RGD		 PMID:21297000 GO_REF:0000033 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Smtn smoothelin acts_upstream_of_or_within ISO MGI:3613293 (PMID:18678771) RGD PMID:18678771 NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886 		JBrowse link
G Tac1 tachykinin, precursor 1 involved_in ISO (PMID:12716968) RGD PMID:12716968 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tac4 tachykinin precursor 4 involved_in ISO (PMID:12716968) RGD PMID:12716968 NCBI chr10:80,207,824...80,216,156
Ensembl chr10:80,207,610...80,216,156 		JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D acts_upstream_of_or_within ISO (PMID:12595294) RGD PMID:12595294 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1857120|MGI:87938 (PMID:10358009), (PMID:11641423)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:10358009 PMID:11641423 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1859675|MGI:87937 (PMID:10358009), (PMID:11641423)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:10358009 PMID:11641423 GO_REF:0000033 GO_REF:0000107 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:10358009)		 GO_Central
RGD		 PMID:10358009 GO_REF:0000033 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    biological regulation 13559
      regulation of biological quality 3418
        regulation of blood pressure 237
          negative regulation of blood pressure 72
            negative regulation of blood pressure in another organism 0
            negative regulation of systemic arterial blood pressure + 35
Path 2
Term Annotations click to browse term
  biological_process 20075
    multicellular organismal process 8904
      system process 3539
        circulatory system process 620
          blood circulation 591
            regulation of blood pressure 237
              negative regulation of blood pressure 72
                negative regulation of blood pressure in another organism 0
                negative regulation of systemic arterial blood pressure + 35
paths to the root