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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of Notch signaling pathway
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Accession:GO:0045746 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: down regulation of Notch signaling pathway;   downregulation of Notch signaling pathway;   negative regulation of N signaling pathway;   negative regulation of N signalling pathway;   negative regulation of Notch signalling pathway
 narrow_synonym: inhibition of Notch signaling pathway


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negative regulation of Notch signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5916812|PMID:23886940)
GO_REF:0000024
(PMID:23886940)
RGD
UniProt
PMID:23886940 PMID:21873635 GO_REF:0000024 MGI:5916812, RGD:13792537 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrdc1 arrestin domain containing 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:23886940)
UniProt
RGD
PMID:23886940 GO_REF:0000024 NCBI chr 3:7,735,002...7,742,195
Ensembl chr 3:7,735,011...7,742,197
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:1890504|MGI:97363 (MGI:5493185|PMID:23160044) RGD PMID:23160044 MGI:5493185 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bend6 BEN domain containing 6 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5484683|PMID:23571214)
(MGI:5688817|PMID:25561495)
RGD PMID:23571214 PMID:25561495 PMID:21873635 MGI:5484683 MGI:5688817, RGD:13792537 NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228
JBrowse link
G Bmp7 bone morphogenetic protein 7 acts_upstream_of_or_within ISO MGI:1099809 (MGI:3612905|PMID:16324690) RGD PMID:16324690 MGI:3612905 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 involved_in ISO (MGI:5629454|PMID:25398765) RGD PMID:25398765 MGI:5629454 NCBI chr 3:142,936,945...143,043,205
Ensembl chr 3:142,936,985...143,043,197
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 involved_in ISO
ISS
(PMID:22445366)
GO_REF:0000024
RGD
UniProt
PMID:22445366 GO_REF:0000024 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:25093684)
MGI:97363 (MGI:5142163|PMID:21419176)
PMID:21873635
RGD PMID:21419176 PMID:25093684 PMID:21873635 MGI:5142163, RGD:13792537 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
JBrowse link
G Dlk2 delta like non-canonical Notch ligand 2 involved_in
acts_upstream_of_or_within
ISO (PMID:25093684)
MGI:97363 (MGI:5142163|PMID:21419176)
RGD PMID:21419176 PMID:25093684 MGI:5142163 NCBI chr 9:14,677,102...14,681,515
Ensembl chr 9:14,676,562...14,681,594
JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Dll3 delta like canonical Notch ligand 3 IDA RGD PMID:16144902 RGD:1599776 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750
JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in IBA
ISO
PMID:21873635
(MGI:5689216|PMID:26114479)
RGD PMID:26114479 PMID:21873635 MGI:5689216, RGD:13792537 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931
JBrowse link
G Dlx1 distal-less homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:94902 (MGI:5487482|PMID:23042297)
Ensembl
RGD
PMID:23042297 GO_REF:0000107 MGI:5487482 NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
JBrowse link
G Dlx2 distal-less homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:94901 (MGI:5487482|PMID:23042297)
Ensembl
RGD
PMID:23042297 GO_REF:0000107 MGI:5487482 NCBI chr 3:56,371,347...56,373,230
Ensembl chr 3:56,370,483...56,373,597
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 acts_upstream_of_or_within ISO (PMID:20947685) RGD PMID:20947685 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO (PMID:16672344) RGD PMID:16672344 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 involved_in
acts_upstream_of_or_within
ISO (MGI:5299268|PMID:21943603)
MGI:5302017 (MGI:5299268|PMID:21943603), (MGI:5437785|PMID:22951639)
RGD PMID:21943603 PMID:22951639 MGI:5299268 MGI:5437785 NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:18239137) RGD PMID:18239137 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:3710697|PMID:11095750), (MGI:5284767|PMID:18239137) RGD PMID:11095750 PMID:18239137 MGI:3710697 MGI:5284767 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor involved_in IBA
ISO
PMID:21873635
(PMID:18299578)
RGD PMID:18299578 PMID:21873635 RGD:13792537 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
JBrowse link
G Kctd10 potassium channel tetramerization domain containing 10 acts_upstream_of_or_within ISO MGI:5751542 (MGI:5691617|PMID:25401743) RGD PMID:25401743 MGI:5691617 NCBI chr12:42,230,159...42,248,792
Ensembl chr12:42,230,269...42,248,783
JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO
GO_REF:0000024
(MGI:5013661|PMID:21572390)
UniProt
RGD
PMID:21572390 GO_REF:0000024 MGI:5013661 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in IBA
ISO
PMID:21873635
(PMID:20847082)
RGD PMID:20847082 PMID:21873635 RGD:13792537 NCBI chr 1:246,066,642...246,152,890
Ensembl chr 1:246,067,100...246,152,903
JBrowse link
G Nfkbia NFKB inhibitor alpha acts_upstream_of_or_within ISO MGI:2176180|MGI:3577709 (MGI:3576806|PMID:15845452) RGD PMID:15845452 MGI:3576806 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Notch4 notch receptor 4 acts_upstream_of_or_within ISO (MGI:5581550|PMID:24667410) RGD PMID:24667410 MGI:5581550 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:19154719)
MGI:97363 (MGI:2663321|PMID:12794108), (MGI:5438472|PMID:21998026)
RGD PMID:12794108 PMID:19154719 PMID:21998026 PMID:21873635 MGI:2663321 MGI:5438472, RGD:13792537 NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133
JBrowse link
G Numb NUMB, endocytic adaptor protein acts_upstream_of_or_within ISO (MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:4950299 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354
JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (PMID:19700410) RGD PMID:19700410 NCBI chr 3:131,677,388...131,707,844
Ensembl chr 3:131,677,391...131,708,359
JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP RGD PMID:11165380 RGD:633801 NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345
JBrowse link
G Rita1 RBPJ interacting and tubulin associated 1 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:21102556)
UniProt
RGD
PMID:21102556 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:35,950,090...35,953,960
Ensembl chr12:35,950,373...35,953,960
JBrowse link
G Slc35c1 solute carrier family 35 member C1 acts_upstream_of_or_within ISO MGI:3709989 (MGI:4849897|PMID:20837470) RGD PMID:20837470 MGI:4849897 NCBI chr 3:78,421,925...78,429,603
Ensembl chr 3:78,421,933...78,428,520
JBrowse link
G Tcim transcriptional and immune response regulator involved_in IBA
ISO
PMID:21873635
(PMID:25985737)
RGD PMID:25985737 PMID:21873635 RGD:13792537 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581
JBrowse link
G Tspan15 tetraspanin 15 involved_in ISO (PMID:30463011) RGD PMID:30463011 NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930
JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3710692|PMID:17495164)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17495164 GO_REF:0000024 GO_REF:0000107 MGI:3710692 NCBI chr 7:8,561,015...8,578,243
Ensembl chr 7:8,563,779...8,576,539
JBrowse link
negative regulation of Notch signaling pathway involved in somitogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISS
ISO
GO_REF:0000024
(MGI:5545944|PMID:23072809)
UniProt
RGD
PMID:23072809 GO_REF:0000024 MGI:5545944 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008
JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein acts_upstream_of_or_within ISO MGI:5317888 (MGI:5317364|PMID:21795391) RGD PMID:21795391 MGI:5317364 NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      signal transduction 6882
        negative regulation of signal transduction 1264
          negative regulation of Notch signaling pathway 35
            negative regulation of Notch signaling pathway involved in somitogenesis 2
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12228
          signal transduction 6882
            cell surface receptor signaling pathway 2779
              Notch signaling pathway 178
                regulation of Notch signaling pathway 86
                  negative regulation of Notch signaling pathway 35
                    negative regulation of Notch signaling pathway involved in somitogenesis 2
paths to the root