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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of Notch signaling pathway
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Accession:GO:0045746 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: down regulation of Notch signaling pathway;   downregulation of Notch signaling pathway;   negative regulation of N signaling pathway;   negative regulation of N signalling pathway;   negative regulation of Notch signalling pathway
 narrow_synonym: inhibition of Notch signaling pathway


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negative regulation of Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO
IBA
ISS
(PMID:23886940)
PMID:21873635
GO_REF:0000024
(MGI:MGI:5916812|PMID:23886940)
RGD
UniProt
PMID:23886940, PMID:21873635 GO_REF:0000024, MGI:MGI:5916812, RGD:13792537 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrdc1 arrestin domain containing 1 ISO
ISS
(PMID:23886940)
GO_REF:0000024
RGD
UniProt
PMID:23886940 GO_REF:0000024 NCBI chr 3:2,129,876...2,137,161
Ensembl chr 3:2,129,879...2,136,936
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:1890504|MGI:MGI:97363 (MGI:MGI:5493185|PMID:23160044) RGD PMID:23160044 MGI:MGI:5493185 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bend6 BEN domain containing 6 ISO
IBA
(MGI:MGI:5484683|PMID:23571214), (MGI:MGI:5688817|PMID:25561495)
PMID:21873635
RGD PMID:23571214, PMID:25561495, PMID:21873635 MGI:MGI:5484683, MGI:MGI:5688817, RGD:13792537 NCBI chr 9:38,297,253...38,351,312
Ensembl chr 9:38,297,322...38,351,024
JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO MGI:MGI:1099809 (MGI:MGI:3612905|PMID:16324690) RGD PMID:16324690 MGI:MGI:3612905 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Cbfa2t2 CBFA2/RUNX1 partner transcriptional co-repressor 2 ISO (MGI:MGI:5629454|PMID:25398765) RGD PMID:25398765 MGI:MGI:5629454 NCBI chr 3:149,935,731...150,041,545
Ensembl chr 3:149,935,731...150,038,257
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 ISO
ISS
(PMID:22445366)
GO_REF:0000024
RGD
UniProt
PMID:22445366 GO_REF:0000024 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO
IBA
MGI:MGI:97363 (MGI:MGI:5142163|PMID:21419176)
PMID:21873635
(PMID:25093684)
RGD PMID:21419176, PMID:25093684, PMID:21873635 MGI:MGI:5142163, RGD:13792537 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Dlk2 delta like non-canonical Notch ligand 2 ISO MGI:MGI:97363 (MGI:MGI:5142163|PMID:21419176)
(PMID:25093684)
RGD PMID:21419176, PMID:25093684 MGI:MGI:5142163 NCBI chr 9:17,061,187...17,065,600
Ensembl chr 9:17,061,190...17,065,600
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dll3 delta like canonical Notch ligand 3 IDA RGD PMID:16144902 RGD:1599776 NCBI chr 1:85,485,875...85,493,683
Ensembl chr 1:85,485,289...85,493,685
JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO
IBA
(MGI:MGI:5689216|PMID:26114479)
PMID:21873635
RGD PMID:26114479, PMID:21873635 MGI:MGI:5689216, RGD:13792537 NCBI chr 3:111,135,011...111,146,746
Ensembl chr 3:111,135,021...111,145,986
JBrowse link
G Dlx1 distal-less homeobox 1 ISO
IEA
MGI:MGI:94902 (MGI:MGI:5487482|PMID:23042297)
GO_REF:0000107
RGD
Ensembl
PMID:23042297 GO_REF:0000107, MGI:MGI:5487482 NCBI chr 3:58,164,931...58,169,521
Ensembl chr 3:58,164,931...58,169,521
JBrowse link
G Dlx2 distal-less homeobox 2 ISO
IEA
MGI:MGI:94901 (MGI:MGI:5487482|PMID:23042297)
GO_REF:0000107
RGD
Ensembl
PMID:23042297 GO_REF:0000107, MGI:MGI:5487482 NCBI chr 3:58,180,088...58,181,971
Ensembl chr 3:58,180,088...58,181,971
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 ISO (PMID:20947685) RGD PMID:20947685 NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936
JBrowse link
G Gata2 GATA binding protein 2 ISO (PMID:16672344) RGD PMID:16672344 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 ISO MGI:MGI:5302017 (MGI:MGI:5299268|PMID:21943603), (MGI:MGI:5437785|PMID:22951639) RGD PMID:21943603, PMID:22951639 MGI:MGI:5299268, MGI:MGI:5437785 NCBI chr 1:164,337,176...164,418,056
Ensembl chr 1:164,380,577...164,418,593
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO
IEA
(PMID:18239137)
GO_REF:0000107
RGD
Ensembl
PMID:18239137 GO_REF:0000107 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO (MGI:MGI:3710697|PMID:11095750), (MGI:MGI:5284767|PMID:18239137) RGD PMID:11095750, PMID:18239137 MGI:MGI:3710697, MGI:MGI:5284767 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor ISO
IBA
(PMID:18299578)
PMID:21873635
RGD PMID:18299578, PMID:21873635 RGD:13792537 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
JBrowse link
G Kctd10 potassium channel tetramerization domain containing 10 ISO MGI:MGI:5751542 (MGI:MGI:5691617|PMID:25401743) RGD PMID:25401743 MGI:MGI:5691617 NCBI chr12:47,992,079...48,010,531
Ensembl chr12:47,992,091...48,010,583
JBrowse link
G LOC684871 similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:72,388,842...72,390,135
Ensembl chr16:72,388,880...72,389,200
JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO
ISS
(MGI:MGI:5013661|PMID:21572390)
GO_REF:0000024
RGD
UniProt
PMID:21572390 GO_REF:0000024, MGI:MGI:5013661 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO
IBA
(PMID:20847082)
PMID:21873635
RGD PMID:20847082, PMID:21873635 RGD:13792537 NCBI chr 1:266,953,006...267,038,879
Ensembl chr 1:266,952,561...267,038,883
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO MGI:MGI:2176180|MGI:MGI:3577709 (MGI:MGI:3576806|PMID:15845452) RGD PMID:15845452 MGI:MGI:3576806 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Notch4 notch receptor 4 ISO (MGI:MGI:5581550|PMID:24667410) RGD PMID:24667410 MGI:MGI:5581550 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein ISO
IBA
(PMID:19154719)
PMID:21873635
MGI:MGI:97363 (MGI:MGI:2663321|PMID:12794108), (MGI:MGI:5438472|PMID:21998026)
RGD PMID:12794108, PMID:19154719, PMID:21998026, PMID:21873635 MGI:MGI:2663321, MGI:MGI:5438472, RGD:13792537 NCBI chr 3:2,396,143...2,398,697
Ensembl chr 3:2,396,143...2,398,689
JBrowse link
G Numb NUMB, endocytic adaptor protein ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Ovol2 ovo-like zinc finger 2 ISO (PMID:19700410) RGD PMID:19700410 NCBI chr 3:138,433,990...138,464,511
Ensembl chr 3:138,433,990...138,462,063
JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP RGD PMID:11165380 RGD:633801 NCBI chr10:109,963,726...109,966,821
Ensembl chr10:109,943,817...109,966,826
JBrowse link
G Rita1 RBPJ interacting and tubulin associated 1 ISO
IBA
ISS
(PMID:21102556)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21102556, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:41,484,970...41,488,889
Ensembl chr12:41,486,076...41,488,885
JBrowse link
G Slc35c1 solute carrier family 35 member C1 ISO MGI:MGI:3709989 (MGI:MGI:4849897|PMID:20837470) RGD PMID:20837470 MGI:MGI:4849897 NCBI chr 3:81,361,080...81,369,010
Ensembl chr 3:81,361,056...81,368,442
JBrowse link
G Tcim transcriptional and immune response regulator ISO
IBA
(PMID:25985737)
PMID:21873635
RGD PMID:25985737, PMID:21873635 RGD:13792537 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
JBrowse link
G Tspan15 tetraspanin 15 ISO (PMID:30463011) RGD PMID:30463011 NCBI chr20:31,812,558...31,857,191
Ensembl chr20:31,813,192...31,857,097
JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:3710692|PMID:17495164)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17495164 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3710692 NCBI chr 7:11,429,266...11,446,119
Ensembl chr 7:11,432,049...11,444,786
JBrowse link
negative regulation of Notch signaling pathway involved in somitogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO
ISS
(MGI:MGI:5545944|PMID:23072809)
GO_REF:0000024
RGD
UniProt
PMID:23072809 GO_REF:0000024, MGI:MGI:5545944 NCBI chr12:16,117,767...16,126,211
Ensembl chr12:16,118,634...16,126,953
JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein ISO MGI:MGI:5317888 (MGI:MGI:5317364|PMID:21795391) RGD PMID:21795391 MGI:MGI:5317364 NCBI chr 3:2,396,143...2,398,697
Ensembl chr 3:2,396,143...2,398,689
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      signal transduction 7016
        negative regulation of signal transduction 1243
          negative regulation of Notch signaling pathway 36
            negative regulation of Notch signaling pathway involved in somitogenesis 2
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of cellular process 12563
          signal transduction 7016
            cell surface receptor signaling pathway 2783
              Notch signaling pathway 178
                regulation of Notch signaling pathway 87
                  negative regulation of Notch signaling pathway 36
                    negative regulation of Notch signaling pathway involved in somitogenesis 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.