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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of DNA repair
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Accession:GO:0045738 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
Synonyms:exact_synonym: down regulation of DNA repair;   downregulation of DNA repair
 narrow_synonym: inhibition of DNA repair


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negative regulation of DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965 		JBrowse link
G RPS3 ribosomal protein S3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:70,460,702...70,466,909
Ensembl chr11:73,762,794...73,768,982 		JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:59,342,820...59,355,386
Ensembl chr11:62,690,542...62,706,542 		JBrowse link
G RNF169 ring finger protein 169 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:69,821,842...69,909,297
Ensembl chr11:73,126,127...73,207,340 		JBrowse link
G TWIST1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) BHF-UCL PMID:17690110 NCBI chr 7:19,761,041...19,765,665 JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941 		JBrowse link
G C1QBP complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:5,481,114...5,487,482
Ensembl chr17:5,473,239...5,479,735 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 involved_in ISO (PMID:28512243) UniProt PMID:28512243 NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126 		JBrowse link
G FANCB FA complementation group B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25520194) TreeGrafter
MGI		 PMID:25520194 GO_REF:0000118 NCBI chr  X:7,470,574...7,500,958
Ensembl chr  X:14,752,934...14,781,817 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:5,931,389...5,978,844
Ensembl chr10:5,915,713...5,962,778 		JBrowse link
G HELB DNA helicase B involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:22,571,448...22,607,417
Ensembl chr12:23,078,732...23,114,134 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,071,118...61,078,667
Ensembl chr11:64,404,572...64,412,667 		JBrowse link
G KLHL15 kelch like family member 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:16,583,117...16,625,029
Ensembl chr  X:23,956,827...23,997,742 		JBrowse link
G KMT5A lysine methyltransferase 5A involved_in ISO (PMID:27338793) UniProt PMID:27338793 NCBI chr12:120,982,059...121,007,360 JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,436,532...10,454,023
Ensembl chr 1:11,654,963...11,661,526 		JBrowse link
G MAGEF1 MAGE family member F1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:181,750,186...181,751,900
Ensembl chr 3:190,229,865...190,230,791 		JBrowse link
G PARPBP PARP1 binding protein involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:99,707,641...99,784,993
Ensembl chr12:103,105,117...103,182,366 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:118,535,968...118,648,275
Ensembl chr 3:125,446,829...125,559,283 		JBrowse link
G RADX RPA1 related single stranded DNA binding protein, X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:95,714,600...95,781,853
Ensembl chr  X:106,092,340...106,159,772 		JBrowse link
G RECQL5 RecQ like helicase 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25520194) Ensembl
MGI		 PMID:25520194 GO_REF:0000107 NCBI chr17:69,577,778...69,618,068
Ensembl chr17:75,128,325...75,168,254 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:38,721,658...38,818,488
Ensembl chr2B:155,985,960...156,052,926 		JBrowse link
G RMI2 RecQ mediated genome instability 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:10,286,136...10,292,377
Ensembl chr16:11,480,066...11,513,561 		JBrowse link
G SENP3 SUMO specific peptidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,593,904...7,603,538
Ensembl chr17:7,580,106...7,589,838 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:5,753,262...5,858,728
Ensembl chr20:5,537,488...5,642,107 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr10:83,639,020...83,643,420 JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 5:48,376,338...48,382,052 JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:11,479,742...11,627,035
Ensembl chr18:13,785,912...13,933,887 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741 		JBrowse link
G UBQLN4 ubiquilin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,374,635...131,395,986
Ensembl chr 1:135,209,490...135,225,666 		JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AUNIP aurora kinase A and ninein interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:25,090,690...25,118,062
Ensembl chr 1:26,157,953...26,185,578 		JBrowse link
G CYREN cell cycle regulator of NHEJ involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:127,130,587...127,148,824 JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,703,720...44,784,948 JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:19549901) UniProt PMID:19549901 NCBI chr12:22,954,946...23,096,623 JBrowse link
G HSF1 heat shock transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966 		JBrowse link
G NUDT16L1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) UniProt PMID:28241136 NCBI chr16:3,615,841...3,620,526
Ensembl chr16:4,785,358...4,786,775 		JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OGG1 8-oxoguanine DNA glycosylase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19506022) MGI
Ensembl		 PMID:19506022 GO_REF:0000107 NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    negative regulation of biological process 5559
      negative regulation of response to stimulus 1754
        negative regulation of DNA repair 38
          negative regulation of base-excision repair 0
          negative regulation of double-strand break repair + 37
          negative regulation of error-prone translesion synthesis 0
          negative regulation of mismatch repair 0
          negative regulation of single strand break repair + 0
Path 2
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      organic substance metabolic process 9869
        organic cyclic compound metabolic process 5562
          nucleobase-containing compound metabolic process 5109
            nucleic acid metabolic process 4613
              DNA metabolic process 917
                DNA repair 513
                  regulation of DNA repair 178
                    negative regulation of DNA repair 38
                      negative regulation of base-excision repair 0
                      negative regulation of double-strand break repair + 37
                      negative regulation of error-prone translesion synthesis 0
                      negative regulation of mismatch repair 0
                      negative regulation of single strand break repair + 0
paths to the root