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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA repair
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Accession:GO:0045738 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
Synonyms:exact_synonym: down regulation of DNA repair;   downregulation of DNA repair
 narrow_synonym: inhibition of DNA repair



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negative regulation of DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:7294462|PMID:35210392) RGD PMID:35210392 MGI:7294462 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:17049931) RGD PMID:17049931 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir221 microRNA 221 involved_in ISO (PMID:24147153) RGD PMID:24147153 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
(PMID:20725033)
UniProt
TreeGrafter
GO_Central
RGD
PMID:20725033 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G Otub1l1 OTU deubiquitinase, ubiquitin aldehyde binding 1 like 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:14,195,783...14,196,918
Ensembl chr 7:14,195,918...14,196,727
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644
JBrowse link
G Rnf169 ring finger protein 169 involved_in ISO (PMID:22492721), (PMID:22733822), (PMID:22742833) RGD PMID:22492721 PMID:22733822 PMID:22742833 NCBI chr 1:154,250,462...154,311,867
Ensembl chr 1:154,254,473...154,311,653
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:9461559) RGD PMID:9461559 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G C1qbp complement C1q binding protein involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:31353207)
Ensembl
UniProt
RGD
PMID:31353207 GO_REF:0000024 GO_REF:0000107 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO
IBA
(PMID:30356214), (PMID:31544964)
GO_REF:0000033
(MGI:6241455|PMID:30356214), (MGI:6370284|PMID:31544964)
RGD
GO_Central
PMID:30356214 PMID:31544964 GO_REF:0000033 MGI:6241455 MGI:6370284 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:28512243)
UniProt
RGD
PMID:28512243 GO_REF:0000024 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Fancb FA complementation group B acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:2156841 (MGI:5648586|PMID:25520194)
GO_REF:0000033
RGD
GO_Central
PMID:25520194 GO_REF:0000033 MGI:5648586 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (PMID:19736316)
(MGI:5566975|PMID:24108124)
RGD PMID:19736316 PMID:24108124 MGI:5566975 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
JBrowse link
G Helb DNA helicase B involved_in ISO (PMID:26774285)
(MGI:5766842|PMID:26774285)
RGD PMID:26774285 MGI:5766842 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585
JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
IEA
(PMID:32832608)
GO_REF:0000107
RGD
Ensembl
PMID:32832608 GO_REF:0000107 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISS
ISO
GO_REF:0000024
(PMID:27561354), (PMID:35219381)
UniProt
RGD
PMID:27561354 PMID:35219381 GO_REF:0000024 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069
JBrowse link
G Kmt5a lysine methyltransferase 5A involved_in ISO (PMID:27338793) RGD PMID:27338793 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Parpbp PARP1 binding protein involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
GO_REF:0000002
(PMID:22153967)
UniProt
TreeGrafter
GO_Central
InterPro
RGD
PMID:22153967 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:22,511,427...22,580,834
Ensembl chr 7:22,511,427...22,573,695
JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:28512243)
Ensembl
UniProt
RGD
PMID:28512243 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:25642963), (PMID:28695890), (PMID:36455556)
(MGI:5621198|PMID:25642960), (MGI:5920742|PMID:28687761), (MGI:6869820|PMID:29058711)
RGD PMID:25642960 PMID:25642963 PMID:28687761 PMID:28695890 PMID:29058711 More... MGI:5621198 MGI:5920742 MGI:6869820 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
JBrowse link
G Radx RPA1 related single stranded DNA binding protein, X-linked involved_in ISO
IEA
ISS
(PMID:28735897)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:28735897 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:103,089,284...103,176,840
Ensembl chr  X:103,089,284...103,176,838
JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO MGI:2448558 (MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:5648586 NCBI chr10:101,126,544...101,165,739
Ensembl chr10:101,126,547...101,165,652
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23333306)
(MGI:5468037|PMID:23306437), (MGI:5476381|PMID:23333305)
RGD PMID:23306437 PMID:23333305 PMID:23333306 MGI:5468037 MGI:5476381 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Rmi2 RecQ mediated genome instability 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235
JBrowse link
G Senp3 SUMO specific peptidase 3 involved_in ISO (PMID:32832608) RGD PMID:32832608 NCBI chr10:54,390,698...54,399,590
Ensembl chr10:54,390,694...54,399,593
JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
(PMID:29656893)
GO_REF:0000033
RGD
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550
JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965
JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 2:35,297,255...35,302,071
Ensembl chr 2:35,295,859...35,302,346
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:25294876) RGD PMID:25294876 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23333306), (PMID:23345425)
(MGI:5476381|PMID:23333305), (MGI:5887194|PMID:20362325)
RGD PMID:20362325 PMID:23333305 PMID:23333306 PMID:23345425 MGI:5476381 MGI:5887194 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:30612738) RGD PMID:30612738 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059
JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aunip aurora kinase A and ninein interacting protein involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:29042561)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29042561 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:146,722,329...146,734,924
Ensembl chr 5:146,722,337...146,736,501
JBrowse link
G Cyren cell cycle regulator of NHEJ involved_in ISO
ISS
IEA
(PMID:28959974)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:28959974 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) RGD PMID:25820262 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19549901)
UniProt
RGD
PMID:19549901 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:26359349) RGD PMID:26359349 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24316220)
UniProt
Ensembl
RGD
PMID:24316220 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) RGD PMID:28241136 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370
JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase acts_upstream_of_or_within ISO (PMID:19506022) RGD PMID:19506022 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20328
    response to stimulus 10881
      negative regulation of response to stimulus 1869
        negative regulation of DNA repair 40
          negative regulation of base-excision repair 0
          negative regulation of double-strand break repair + 39
          negative regulation of error-prone translesion synthesis 0
          negative regulation of mismatch repair 0
          negative regulation of single strand break repair + 0
Path 2
Term Annotations click to browse term
  biological_process 20328
    metabolic process 11732
      cellular metabolic process 10286
        cellular aromatic compound metabolic process 5963
          nucleobase-containing compound metabolic process 5720
            nucleic acid metabolic process 5123
              DNA metabolic process 985
                DNA repair 560
                  regulation of DNA repair 177
                    negative regulation of DNA repair 40
                      negative regulation of base-excision repair 0
                      negative regulation of double-strand break repair + 39
                      negative regulation of error-prone translesion synthesis 0
                      negative regulation of mismatch repair 0
                      negative regulation of single strand break repair + 0
paths to the root