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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA repair
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Accession:GO:0045738 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
Synonyms:exact_synonym: down regulation of DNA repair;   downregulation of DNA repair
 narrow_synonym: inhibition of DNA repair



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negative regulation of DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:7294462|PMID:35210392) RGD PMID:35210392 MGI:7294462 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:17049931) RGD PMID:17049931 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir221 microRNA 221 involved_in ISO (PMID:24147153) RGD PMID:24147153 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:20725033)
UniProt
RGD
PMID:20725033 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:122,545,029...122,563,651
Ensembl chr 6:122,545,061...122,563,644
JBrowse link
G Rnf169 ring finger protein 169 involved_in ISO (PMID:22492721), (PMID:22733822), (PMID:22742833) RGD PMID:22492721 PMID:22733822 PMID:22742833 NCBI chr 1:154,250,462...154,311,867
Ensembl chr 1:154,254,473...154,311,653
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 involved_in ISO
ISS
(PMID:22884692)
GO_REF:0000024
RGD
UniProt
PMID:22884692 GO_REF:0000024 NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO
ISS
(PMID:22884692)
GO_REF:0000024
RGD
UniProt
PMID:22884692 GO_REF:0000024 NCBI chr 7:69,116,758...69,224,490
Ensembl chr 7:69,116,761...69,224,903
JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in IBA
ISO
PMID:21873635
(MGI:6241455|PMID:30356214), (MGI:6370284|PMID:31544964)
(PMID:30356214), (PMID:31544964)
RGD PMID:30356214 PMID:31544964 PMID:21873635 MGI:6241455 MGI:6370284, RGD:13792537 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Fancb FA complementation group B acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:2156841 (MGI:5648586|PMID:25520194)
PMID:21873635
RGD PMID:25520194 PMID:21873635 MGI:5648586, RGD:13792537 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (PMID:19736316)
(MGI:5566975|PMID:24108124)
RGD PMID:19736316 PMID:24108124 MGI:5566975 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
JBrowse link
G Helb DNA helicase B involved_in IBA
ISO
PMID:21873635
(MGI:5766842|PMID:26774285)
(PMID:26774285)
RGD PMID:26774285 PMID:21873635 MGI:5766842, RGD:13792537 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585
JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISO
ISS
(PMID:27561354)
(PMID:27561354), (PMID:35219381)
GO_REF:0000024
RGD
UniProt
PMID:27561354 PMID:35219381 GO_REF:0000024 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Parpbp PARP1 binding protein involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000002
PMID:21873635
(PMID:22153967)
UniProt
InterPro
RGD
PMID:22153967 PMID:21873635 GO_REF:0000002 GO_REF:0000024, RGD:13792537 NCBI chr 7:22,511,427...22,580,834
Ensembl chr 7:22,511,427...22,573,695
JBrowse link
G Pmch pro-melanin-concentrating hormone involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:25642963)
(MGI:5621198|PMID:25642960)
RGD PMID:25642960 PMID:25642963 MGI:5621198 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
JBrowse link
G Radx RPA1 related single stranded DNA binding protein, X-linked involved_in ISO
ISS
(PMID:28735897)
GO_REF:0000024
RGD
UniProt
PMID:28735897 GO_REF:0000024 NCBI chr  X:103,089,284...103,176,840
Ensembl chr  X:103,089,284...103,176,838
JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO MGI:2448558 (MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:5648586 NCBI chr10:101,126,544...101,165,739
Ensembl chr10:101,126,547...101,165,652
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23333306)
(MGI:5468037|PMID:23306437), (MGI:5476381|PMID:23333305)
RGD PMID:23306437 PMID:23333305 PMID:23333306 MGI:5468037 MGI:5476381 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Rmi2 RecQ mediated genome instability 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235
JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
(PMID:29656893)
PMID:21873635
RGD PMID:29656893 PMID:21873635 RGD:13792537 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550
JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965
JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 2:35,294,956...35,301,865
Ensembl chr 2:35,295,859...35,302,346
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:25294876) RGD PMID:25294876 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23333306), (PMID:23345425)
(MGI:5476381|PMID:23333305), (MGI:5887194|PMID:20362325)
RGD PMID:20362325 PMID:23333305 PMID:23333306 PMID:23345425 MGI:5476381 MGI:5887194 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:30612738) RGD PMID:30612738 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059
JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aunip aurora kinase A and ninein interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:29042561)
UniProt
RGD
PMID:29042561 GO_REF:0000024 NCBI chr 5:146,722,157...146,736,233
Ensembl chr 5:146,722,337...146,736,501
JBrowse link
G Cyren cell cycle regulator of NHEJ involved_in ISO
IEA
ISS
(PMID:28959974)
GO_REF:0000002
GO_REF:0000024
RGD
InterPro
UniProt
PMID:28959974 GO_REF:0000002 GO_REF:0000024 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) RGD PMID:25820262 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19549901)
UniProt
RGD
PMID:19549901 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:26359349) RGD PMID:26359349 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) RGD PMID:28241136 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370
JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase acts_upstream_of_or_within ISO (PMID:19506022) RGD PMID:19506022 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    cellular process 18676
      negative regulation of cellular process 5124
        negative regulation of response to DNA damage stimulus 81
          negative regulation of DNA repair 34
            negative regulation of base-excision repair 0
            negative regulation of double-strand break repair + 33
            negative regulation of error-prone translesion synthesis 0
            negative regulation of mismatch repair 0
            negative regulation of single strand break repair + 0
Path 2
Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      cellular metabolic process 10396
        cellular aromatic compound metabolic process 6013
          nucleobase-containing compound metabolic process 5780
            nucleic acid metabolic process 5198
              DNA metabolic process 1028
                DNA repair 525
                  regulation of DNA repair 178
                    negative regulation of DNA repair 34
                      negative regulation of base-excision repair 0
                      negative regulation of double-strand break repair + 33
                      negative regulation of error-prone translesion synthesis 0
                      negative regulation of mismatch repair 0
                      negative regulation of single strand break repair + 0
paths to the root