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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of megakaryocyte differentiation
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Accession:GO:0045653 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
Synonyms:exact_synonym: down regulation of megakaryocyte differentiation;   downregulation of megakaryocyte differentiation
 narrow_synonym: inhibition of megakaryocyte differentiation



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negative regulation of megakaryocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIB1 calcium and integrin binding 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:53,184,713...53,209,195
Ensembl chr 3:53,184,714...53,188,224
JBrowse link
G GABPA GA binding protein transcription factor subunit alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3808108|PMID:16757682) MGI
Ensembl
PMID:16757682 GO_REF:0000107 MGI:3808108 NCBI chr31:21,216,931...21,251,658
Ensembl chr31:21,216,710...21,248,792
JBrowse link
G H4-16 H4 histone 16 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr27:31,839,899...31,840,463
Ensembl chr27:31,840,011...31,840,322
JBrowse link
G H4C11 H4 clustered histone 11 involved_in ISO (PMID:18474616) UniProt PMID:18474616 NCBI chr35:25,009,935...25,012,013
Ensembl chr35:25,011,693...25,011,998
JBrowse link
G H4C12 H4 clustered histone 12 involved_in ISO (PMID:18474616) UniProt PMID:18474616
G H4C13 H4 clustered histone 13 involved_in ISO (PMID:18474616) UniProt PMID:18474616 NCBI chr35:25,015,108...25,051,906 JBrowse link
G H4C14 H4 clustered histone 14 involved_in ISO (PMID:18474616) UniProt PMID:18474616 NCBI chr17:59,129,585...59,130,048
Ensembl chr17:59,129,682...59,129,993
JBrowse link
G H4C4 H4 clustered histone 4 involved_in ISO (PMID:18474616) UniProt PMID:18474616 NCBI chr35:24,121,320...24,124,986 JBrowse link
G H4C8 H4 clustered histone 8 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr35:24,174,401...24,194,848
Ensembl chr27:31,840,011...31,840,322
Ensembl chr17:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
Ensembl chr35:31,840,011...31,840,322
JBrowse link
G H4C9 H4 clustered histone 9 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr35:24,555,412...24,556,402
Ensembl chr35:24,556,015...24,556,326
JBrowse link
G MIR486 microRNA mir-486 involved_in ISO (PMID:25857263) BHF-UCL PMID:25857263 NCBI chr16:23,958,963...23,959,026
Ensembl chr16:23,958,963...23,959,026
JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in ISO (PMID:25857263) BHF-UCL PMID:25857263 NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969
JBrowse link
G PRMT1 protein arginine methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:106,849,864...106,859,896
Ensembl chr 1:106,849,864...106,874,075
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16442
    cellular process 15494
      negative regulation of cellular process 4946
        negative regulation of cell differentiation 750
          negative regulation of myeloid cell differentiation 95
            negative regulation of megakaryocyte differentiation 13
Path 2
Term Annotations click to browse term
  biological_process 16442
    developmental process 6558
      anatomical structure development 6130
        multicellular organism development 5252
          system development 4797
            immune system development 1103
              hematopoietic or lymphoid organ development 1037
                hemopoiesis 988
                  myeloid cell differentiation 454
                    megakaryocyte differentiation 58
                      regulation of megakaryocyte differentiation 31
                        negative regulation of megakaryocyte differentiation 13
paths to the root