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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of megakaryocyte differentiation
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Accession:GO:0045653 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
Synonyms:exact_synonym: down regulation of megakaryocyte differentiation;   downregulation of megakaryocyte differentiation
 narrow_synonym: inhibition of megakaryocyte differentiation



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negative regulation of megakaryocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cib1 calcium and integrin binding 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5314162|PMID:22128142)
UniProt
RGD
PMID:22128142 GO_REF:0000024 MGI:5314162 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha acts_upstream_of_or_within ISO MGI:3054951 (MGI:3808108|PMID:16757682) RGD PMID:16757682 MGI:3808108 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605
JBrowse link
G H4c3 H4 clustered histone 3 involved_in ISO (PMID:18474616) RGD PMID:18474616
G H4f16 H4 histone 16 involved_in ISO (PMID:18474616) RGD PMID:18474616
G Hist1h4b histone cluster 1 H4 family member B involved_in ISO (PMID:18474616) RGD PMID:18474616 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
JBrowse link
G Hist1h4m histone cluster 1, H4m involved_in ISO (PMID:18474616) RGD PMID:18474616 NCBI chr17:42,698,054...42,698,365
Ensembl chr17:42,698,025...42,698,958
JBrowse link
G Hist2h4 histone cluster 2, H4 involved_in ISO (PMID:18474616) RGD PMID:18474616 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048
JBrowse link
G Hist2h4a histone cluster 2 H4 family member A involved_in ISO (PMID:18474616) RGD PMID:18474616
G LOC100912290 histone H4-like involved_in ISO (PMID:18474616) RGD PMID:18474616
G LOC102548682 histone H4-like involved_in ISO (PMID:18474616) RGD PMID:18474616 NCBI chr17:41,368,743...41,426,735 JBrowse link
G LOC102551184 histone H4-like involved_in ISO (PMID:18474616) RGD PMID:18474616 NCBI chr17:41,526,192...41,575,488 JBrowse link
G Mir486 microRNA 486 involved_in ISO (PMID:25857263) RGD PMID:25857263
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:25857263) RGD PMID:25857263 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Pf4 platelet factor 4 involved_in ISS
ISO
GO_REF:0000024
(PMID:2140694)
UniProt
RGD
PMID:2140694 GO_REF:0000024 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in ISO
ISS
(PMID:20442406)
GO_REF:0000024
RGD
UniProt
PMID:20442406 GO_REF:0000024 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G RGD1562378 histone H4 variant H4-v.1 involved_in ISO (PMID:18474616) RGD PMID:18474616

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      negative regulation of cellular process 5057
        negative regulation of cell differentiation 775
          negative regulation of myeloid cell differentiation 101
            negative regulation of megakaryocyte differentiation 16
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            immune system development 1129
              hematopoietic or lymphoid organ development 1061
                hemopoiesis 1012
                  myeloid cell differentiation 466
                    megakaryocyte differentiation 62
                      regulation of megakaryocyte differentiation 34
                        negative regulation of megakaryocyte differentiation 16
paths to the root