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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of T-helper cell differentiation
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Accession:GO:0045624 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of T-helper cell differentiation;   upregulation of T-helper cell differentiation
 narrow_synonym: activation of T-helper cell differentiation;   stimulation of T-helper cell differentiation
 related_synonym: positive regulation of T-helper cell development


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positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (MGI:5617929|PMID:24645804) RGD PMID:24645804 MGI:5617929 NCBI chr 5:60,970,650...61,077,881
Ensembl chr 5:60,971,257...61,077,627
JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO
IBA
ISS
(PMID:17008549)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17008549, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:2176424 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:4436838 NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha involved_in ISO
IBA
(MGI:3851279|PMID:19501566)
PMID:21873635
RGD PMID:19501566, PMID:21873635, PMID:21873635 MGI:3851279, RGD:13792537, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    immune system process 2906
      immune effector process 728
        positive regulation of immune effector process 270
          positive regulation of T-helper cell differentiation 19
            positive regulation of T-helper 1 cell differentiation 5
            positive regulation of T-helper 17 cell differentiation + 6
            positive regulation of T-helper 2 cell differentiation 7
Path 2
Term Annotations click to browse term
  biological_process 20082
    developmental process 6853
      anatomical structure development 6313
        multicellular organism development 5789
          system development 5317
            immune system development 1089
              hematopoietic or lymphoid organ development 1023
                hemopoiesis 971
                  leukocyte differentiation 607
                    mononuclear cell differentiation 473
                      lymphocyte differentiation 420
                        T cell differentiation 296
                          T cell differentiation involved in immune response 79
                            alpha-beta T cell differentiation involved in immune response 71
                              CD4-positive, alpha-beta T cell differentiation involved in immune response 70
                                T-helper cell differentiation 68
                                  regulation of T-helper cell differentiation 40
                                    positive regulation of T-helper cell differentiation 19
                                      positive regulation of T-helper 1 cell differentiation 5
                                      positive regulation of T-helper 17 cell differentiation + 6
                                      positive regulation of T-helper 2 cell differentiation 7
paths to the root