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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of T-helper cell differentiation
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Accession:GO:0045622 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: regulation of T-helper cell development


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regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3817343|PMID:18776904) MGI
Ensembl
PMID:18776904 GO_REF:0000107 MGI:3817343 NCBI chrNW_004936484:6,780,692...6,800,883
Ensembl chrNW_004936484:6,780,692...6,800,966
JBrowse link
G LOC101969065 mamu class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:540,225...544,968
Ensembl chrNW_004936727:540,217...545,036
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3817343|PMID:18776904) MGI
Ensembl
PMID:18776904 GO_REF:0000107 MGI:3817343 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163
JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761239|PMID:16424184) MGI
Ensembl
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818
JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139
JBrowse link
G Foxp3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308
JBrowse link
G Il2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:11,341,663...11,393,275
Ensembl chrNW_004936487:11,341,700...11,389,859
JBrowse link
G Smad7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5450776|PMID:23034280) MGI
Ensembl
PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163
JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:19,714,145...19,722,512
Ensembl chrNW_004936474:19,714,153...19,722,528
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:745,798...765,926
Ensembl chrNW_004936556:745,798...765,918
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139
JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2450484|PMID:12594267) MGI
Ensembl
PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071
JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761239|PMID:16424184) MGI
Ensembl
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022
Ensembl chrNW_004936508:5,531,002...5,587,549
JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3580753|PMID:15917799) MGI
Ensembl
PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677
JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chrNW_004936524:2,765,271...2,767,259
Ensembl chrNW_004936524:2,765,267...2,767,385
JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761239|PMID:16424184) MGI
Ensembl
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588
JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2176424|PMID:11894097) MGI
Ensembl
PMID:11894097 GO_REF:0000107 MGI:2176424 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022
Ensembl chrNW_004936508:5,531,002...5,587,549
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:5,854,361...5,910,719
Ensembl chrNW_004936497:5,853,870...5,904,266
JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004936570:464,513...471,333
Ensembl chrNW_004936570:463,974...471,344
JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936630:1,601,006...1,633,844
Ensembl chrNW_004936630:1,601,010...1,632,745
JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,807,179...25,818,914
Ensembl chrNW_004936476:25,807,163...25,818,899
JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518
JBrowse link
G Ep300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936646:743,630...745,998
Ensembl chrNW_004936646:743,688...745,836
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761239|PMID:16424184) MGI
Ensembl
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) MGI PMID:12594267 MGI:2450484 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718
JBrowse link
G Prkcz protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:1,303,502...1,383,135
Ensembl chrNW_004936737:1,303,887...1,321,944
JBrowse link
G Rara retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,376,217...15,420,638
Ensembl chrNW_004936490:15,376,205...15,421,611
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) BHF-UCL PMID:18354165 MGI:4943387 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5617929|PMID:24645804) MGI
Ensembl
PMID:24645804 GO_REF:0000107 MGI:5617929 NCBI chrNW_004936524:5,698,101...5,832,801
Ensembl chrNW_004936524:5,701,566...5,834,539
JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:11,972,715...11,978,152
Ensembl chrNW_004936501:11,973,385...11,976,583
JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004936525:8,238,128...8,240,974
Ensembl chrNW_004936525:8,237,831...8,240,974
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004936489:16,669,297...16,689,451
Ensembl chrNW_004936489:16,669,297...16,689,451
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15868
    immune system process 2192
      immune effector process 580
        regulation of immune effector process 381
          regulation of T-helper cell differentiation 38
            negative regulation of T-helper cell differentiation + 18
            positive regulation of T-helper cell differentiation + 20
            regulation of T-helper 1 cell differentiation + 10
            regulation of T-helper 17 cell differentiation + 21
            regulation of T-helper 2 cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 15868
    cellular process 14991
      cellular developmental process 4250
        cell differentiation 4249
          cell development 3048
            hemopoiesis 955
              leukocyte differentiation 605
                mononuclear cell differentiation 452
                  lymphocyte differentiation 401
                    T cell differentiation 298
                      T cell differentiation involved in immune response 80
                        alpha-beta T cell differentiation involved in immune response 73
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 72
                            T-helper cell differentiation 70
                              regulation of T-helper cell differentiation 38
                                negative regulation of T-helper cell differentiation + 18
                                positive regulation of T-helper cell differentiation + 20
                                regulation of T-helper 1 cell differentiation + 10
                                regulation of T-helper 17 cell differentiation + 21
                                regulation of T-helper 2 cell differentiation + 12
paths to the root