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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of lymphocyte differentiation
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Accession:GO:0045621 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of lymphocyte differentiation;   upregulation of lymphocyte differentiation
 narrow_synonym: activation of lymphocyte differentiation;   stimulation of lymphocyte differentiation
 related_synonym: positive regulation of lymphocyte development


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positive regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:5544783 (MGI:5509072|PMID:23918385) RGD PMID:23918385 MGI:5509072 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (MGI:1266928|PMID:9620849) RGD PMID:9620849 MGI:1266928 NCBI chr 9:88,287,680...88,392,748 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934 JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (MGI:6414739|PMID:32103174) RGD PMID:32103174 MGI:6414739 NCBI chr11:85,040,790...85,258,357 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,785,537...85,809,869 JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO MGI:103036 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Xrcc6 X-ray repair cross complementing 6 involved_in ISO (MGI:6414739|PMID:32103174) RGD PMID:32103174 MGI:6414739 NCBI chr 7:113,542,992...113,563,762 JBrowse link
positive regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117 (MGI:3620422|PMID:12163459), (MGI:3690682|PMID:11067867), (MGI:3774231|PMID:16670300) RGD PMID:11067867 PMID:12163459 PMID:16670300 MGI:3620422 MGI:3690682 MGI:3774231 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:3695957|PMID:15855276) RGD PMID:15855276 MGI:3695957 NCBI chr17:49,438,567...49,709,712 JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532 JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:3039799 (MGI:3039326|PMID:15064401) RGD PMID:15064401 MGI:3039326 NCBI chr13:92,069,160...92,164,281 JBrowse link
G Nkap NFKB activating protein involved_in ISO
IEA
ISS
(PMID:19409814)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19409814 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:116,373,031...116,392,677 JBrowse link
G Pnp purine nucleoside phosphorylase acts_upstream_of_or_within ISO (PMID:16964310) RGD PMID:16964310 NCBI chr15:24,170,456...24,178,274 JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:5640904 NCBI chr 8:108,991,926...109,025,746 JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3029054|PMID:14764698)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:14764698 GO_REF:0000024 GO_REF:0000107 MGI:3029054 NCBI chr 4:6,954,017...6,963,170 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:99613 (MGI:1096306|PMID:9275205)
Ensembl
RGD
PMID:9275205 GO_REF:0000107 MGI:1096306 NCBI chr17:12,604,615...12,678,437 JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447|MGI:3526403|MGI:99515 (MGI:1096306|PMID:9275205), (MGI:75253|PMID:7630421), (MGI:893249|PMID:9208839) RGD PMID:7630421 PMID:9208839 PMID:9275205 MGI:1096306 MGI:75253 MGI:893249 NCBI chr 9:38,989,750...39,011,701 JBrowse link
positive regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11c ATPase phospholipid transporting 11C involved_in ISO (MGI:5002406|PMID:21423173) RGD PMID:21423173 MGI:5002406 NCBI chr  X:138,564,459...138,752,116 JBrowse link
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within ISO MGI:3029528 (MGI:3029504|PMID:12431371) RGD PMID:12431371 MGI:3029504 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Cd27 CD27 molecule involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:158,030,700...158,035,862 JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:2429736 (MGI:1095961|PMID:9252128) RGD PMID:9252128 MGI:1095961 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3655025|PMID:16797412)
Ensembl
RGD
PMID:16797412 GO_REF:0000107 MGI:3655025 NCBI chr 2:94,235,219...94,280,075 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849), (MGI:1354084|PMID:10704460)
Ensembl
RGD
PMID:9620849 PMID:10704460 GO_REF:0000107 MGI:1266928 MGI:1354084 NCBI chr 9:88,287,680...88,392,748 JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO
GO_REF:0000024
(MGI:5013661|PMID:21572390)
UniProt
RGD
PMID:21572390 GO_REF:0000024 MGI:5013661 NCBI chr15:27,887,795...27,897,020 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934 JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (MGI:4839685|PMID:20870947) RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712 JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3759678 (MGI:3589325|PMID:16129705)
RGD PMID:16129705, PMID:21873635 MGI:3589325, RGD:13792537 NCBI chr 6:72,647,025...72,670,885 JBrowse link
G Prdm1 PR/SET domain 1 acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
ISO (MGI:3826899|PMID:18845144) RGD PMID:18845144 MGI:3826899 NCBI chr20:47,959,858...47,981,488 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:1889695|PMID:10979977) RGD PMID:10979977 MGI:1889695 NCBI chr10:85,785,537...85,809,869 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (MGI:1889695|PMID:10979977)
Ensembl
RGD
PMID:10979977 GO_REF:0000107 MGI:1889695 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
MGI:1857421|MGI:2384078 (MGI:77314|PMID:7477352), (MGI:77315|PMID:7477353)
(PMID:18369315)
Ensembl
RGD
PMID:7477352 PMID:7477353 PMID:18369315, PMID:21873635 GO_REF:0000107 MGI:77314 MGI:77315, RGD:13792537 NCBI chr17:12,604,615...12,678,437 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
(PMID:11460154)
GO_REF:0000024
RGD
UniProt
PMID:11460154 GO_REF:0000024 NCBI chr14:80,390,629...80,395,713 JBrowse link
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 molecule acts_upstream_of_or_within ISO MGI:3055293 (MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:3054335 NCBI chr17:20,887,309...20,907,009 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934 JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:127,326,815...127,341,521 JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6140589|PMID:24880459)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24880459 GO_REF:0000024 GO_REF:0000107 MGI:6140589 NCBI chr10:4,882,651...4,884,342 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:73,723,329...73,746,809 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6140589|PMID:24880459) RGD PMID:24880459 MGI:6140589 NCBI chr 2:174,795,831...174,811,980 JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (MGI:2653673|PMID:12612578), (MGI:3695768|PMID:16275384), (MGI:3700459|PMID:16301745), (MGI:3799419|PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 MGI:2653673 MGI:3695768 MGI:3700459 MGI:3799419 NCBI chr  X:14,908,494...14,924,994 JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:77,693,417...77,701,025 JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,513,464...4,518,457 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,548,664...4,558,237 JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224 JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr19:33,049,162...33,092,752 JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:69,805,020...69,810,628 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934 JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3772948|PMID:18258917)
UniProt
RGD
PMID:18258917 GO_REF:0000024 MGI:3772948 NCBI chr11:31,839,880...32,074,427 JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr 5:147,393,926...147,419,161 JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in ISO (PMID:10209962) RGD PMID:10209962 NCBI chr 1:202,690,472...202,699,136 JBrowse link
G Tnfsf9 TNF superfamily member 9 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:19187795, PMID:21873635 RGD:2317344, RGD:13792537 NCBI chr 9:1,944,017...1,946,351 JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:11859104 RGD:625608 NCBI chr 4:77,693,417...77,701,025 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:1857211 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr 5:141,888,319...141,916,992 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5486619|PMID:23562159)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23562159 GO_REF:0000024 GO_REF:0000107 MGI:5486619 NCBI chr 2:219,666,549...219,779,815 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934 JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr13:49,596,193...49,708,283 JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO (MGI:5486619|PMID:23562159) RGD PMID:23562159 MGI:5486619 NCBI chr13:44,831,097...44,875,522 JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (MGI:5486619|PMID:23562159) RGD PMID:23562159 MGI:5486619 NCBI chr17:35,667,809...35,672,515 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,785,537...85,809,869 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (MGI:3054293|PMID:15294943)
Ensembl
RGD
PMID:15294943 GO_REF:0000107 MGI:3054293 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857421|MGI:2384078 (MGI:77314|PMID:7477352), (MGI:83585|PMID:8790395)
Ensembl
RGD
PMID:7477352 PMID:8790395 GO_REF:0000107 MGI:77314 MGI:83585 NCBI chr17:12,604,615...12,678,437 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:106,575,586...106,606,325 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:3027369 NCBI chr 7:721,809...723,923 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6119963|PMID:29230018)
UniProt
RGD
PMID:29230018 GO_REF:0000024 MGI:6119963 NCBI chr 3:161,930,256...161,936,205 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:27591323) RGD PMID:27591323 NCBI chr20:4,513,464...4,518,457 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:27591323) RGD PMID:27591323 NCBI chr20:4,548,664...4,558,237 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:3806904 NCBI chr13:73,723,329...73,746,809 JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:81,265,656...81,296,278 JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr 1:95,615,056...95,620,463 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:18840707)
UniProt
RGD
PMID:18840707 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904 JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO MGI:1931086|MGI:2136897 (MGI:3701546|PMID:14607906), (MGI:3703651|PMID:17318811) RGD PMID:14607906 PMID:17318811 MGI:3701546 MGI:3703651 NCBI chr19:25,640,013...25,706,818 JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1934016 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr17:66,802,300...66,831,973 JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:120,119,598...120,126,941 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:104,168,549...104,230,107 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (MGI:3655409|PMID:9841920) RGD PMID:9841920 MGI:3655409 NCBI chr10:85,785,537...85,809,869 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 MGI:3655409 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO MGI:3773716 (MGI:4834966|PMID:20818394) RGD PMID:20818394 MGI:4834966 NCBI chr 5:19,874,994...20,171,272 JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:95,096,838...95,125,811 JBrowse link
positive regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO MGI:1856989 (MGI:2679144|PMID:14557411) RGD PMID:14557411 MGI:2679144 NCBI chr 2:25,600,069...25,800,937 JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 acts_upstream_of_or_within ISO MGI:1856083 (MGI:2679144|PMID:14557411) RGD PMID:14557411 MGI:2679144 NCBI chr 7:8,970,249...9,005,651 JBrowse link
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO MGI:2180711|MGI:2180713 (MGI:2180705|PMID:10201995), (MGI:87097|PMID:9133426) RGD PMID:9133426 PMID:10201995 MGI:2180705 MGI:87097 NCBI chr 2:172,423,582...172,427,089 JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158690|MGI:2158738 (MGI:1340364|PMID:10366784) RGD PMID:10366784 MGI:1340364 NCBI chr14:86,255,065...86,340,839 JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 acts_upstream_of_or_within ISO MGI:2183502|MGI:2386448 (MGI:3686949|PMID:16973387) RGD PMID:16973387 MGI:3686949 NCBI chr 8:115,794,537...115,883,615 JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in ISO (MGI:3807724|PMID:18660811) RGD PMID:18660811 MGI:3807724 NCBI chr 8:48,989,376...49,177,011 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 acts_upstream_of ISO UniProtKB:P60568 (PMID:22962438) RGD PMID:22962438 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il2 interleukin 2 acts_upstream_of ISO UniProtKB:P22301 (PMID:22962438) RGD PMID:22962438 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Xbp1 X-box binding protein 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:11460154)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713 JBrowse link
positive regulation of pro-T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:95,096,838...95,125,811 JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621 JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:4462559|MGI:5547539 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:33,571,255...33,586,783 JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:106,575,586...106,606,325 JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:22387553) RGD PMID:22387553 NCBI chr13:95,613,716...95,651,716 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:2654936 (MGI:2450778|PMID:12522256), (MGI:3041050|PMID:15100250), (MGI:3574163|PMID:15780990), (MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180) RGD PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 MGI:2450778 MGI:3041050 MGI:3574163 MGI:3693968 MGI:3697020 NCBI chr  X:14,908,494...14,924,994 JBrowse link
G Il2 interleukin 2 IDA RGD PMID:6233372 RGD:1600097 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:25778793) RGD PMID:25778793 NCBI chr 1:95,299,457...95,324,564 JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224 JBrowse link
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr 1:65,326,832...65,334,683 JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr 1:69,805,020...69,810,628 JBrowse link
G Mir214 microRNA 214 IMP RGD PMID:30287503 RGD:38549580 NCBI chr13:74,588,374...74,588,481 JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO
IEA
(PMID:22387553)
GO_REF:0000107
RGD
Ensembl
PMID:22387553 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342 JBrowse link
G Sox12 SRY-box transcription factor 12 involved_in ISO (MGI:6203502|PMID:30190287) RGD PMID:30190287 MGI:6203502 NCBI chr 3:140,859,499...140,860,518 JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262 JBrowse link
positive regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:2155238|PMID:9478961), (MGI:72798|PMID:7731963) RGD PMID:7731963 PMID:9478961 MGI:2155238 MGI:72798 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Bad BCL2-associated agonist of cell death acts_upstream_of_or_within ISO MGI:3029528 (MGI:3029504|PMID:12431371) RGD PMID:12431371 MGI:3029504 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Cd27 CD27 molecule involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:158,030,700...158,035,862 JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205|MGI:1927530 (MGI:3033881|PMID:9432982), (MGI:52620|PMID:7679955), (MGI:79110|PMID:8598040) RGD PMID:7679955 PMID:8598040 PMID:9432982 MGI:3033881 MGI:52620 MGI:79110 NCBI chr18:54,256,757...54,266,003 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO MGI:3664438 (MGI:3656194|PMID:16501569) RGD PMID:16501569 MGI:3656194 NCBI chr19:18,310,632...18,373,696 JBrowse link
G Gata3 GATA binding protein 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5285154|PMID:20696860)
UniProt
RGD
PMID:20696860 GO_REF:0000024 MGI:5285154 NCBI chr17:68,643,760...68,666,000 JBrowse link
G Il12a interleukin 12A acts_upstream_of_or_within ISO MGI:1916927 (MGI:5461742|PMID:22968459) RGD PMID:22968459 MGI:5461742 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il1rl2 interleukin 1 receptor-like 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5461742|PMID:22968459)
Ensembl
RGD
PMID:22968459 GO_REF:0000107 MGI:5461742 NCBI chr 9:42,591,658...42,639,351 JBrowse link
G Il2 interleukin 2 IDA RGD PMID:9352365 RGD:1600138 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha IMP RGD PMID:9352365 RGD:1600138 NCBI chr17:66,849,974...66,898,665 JBrowse link
G Il36b interleukin 36, beta involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:96539 (MGI:5461742|PMID:22968459)
RGD PMID:22968459, PMID:21873635 MGI:5461742, RGD:13792537 NCBI chr 3:7,024,862...7,122,489 JBrowse link
G Il4 interleukin 4 involved_in IBA
ISO
PMID:21873635
(PMID:20554961)
RGD PMID:20554961, PMID:21873635 RGD:13792537 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
GO_REF:0000107
(MGI:3029504|PMID:12431371)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12431371 GO_REF:0000024 GO_REF:0000107 MGI:3029504 NCBI chr 2:94,235,219...94,280,075 JBrowse link
G LOC100909593 class II histocompatibility antigen, M alpha chain-like acts_upstream_of_or_within ISO MGI:1861933|MGI:2384509|MGI:2652160 (MGI:3033881|PMID:9432982), (MGI:79110|PMID:8598040), (MGI:79111|PMID:8598041), (MGI:79272|PMID:8638109) RGD PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 MGI:3033881 MGI:79110 MGI:79111 MGI:79272
G Mdk midkine involved_in ISS
ISO
GO_REF:0000024
(MGI:5897914|PMID:28183532)
UniProt
RGD
PMID:28183532 GO_REF:0000024 MGI:5897914 NCBI chr 3:77,901,156...77,903,997 JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 involved_in ISO (MGI:3641361|PMID:12707323) RGD PMID:12707323 MGI:3641361 NCBI chr10:53,203,930...53,255,229 JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:80946 NCBI chr13:49,596,193...49,708,283 JBrowse link
G Rag1 recombination activating 1 involved_in ISO (MGI:50458|PMID:1547488) RGD PMID:1547488 MGI:50458 NCBI chr 3:87,917,061...87,928,158 JBrowse link
G Rhoh ras homolog family member H involved_in ISO (PMID:22850876) RGD PMID:22850876 NCBI chr14:42,341,135...42,371,971 JBrowse link
G RT1-Ba RT1 class II, locus Ba involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:79111|PMID:8598041)
Ensembl
RGD
PMID:8598041 GO_REF:0000107 MGI:79111 NCBI chr20:4,575,134...4,579,727 JBrowse link
G RT1-DMa RT1 class II, locus DMa acts_upstream_of_or_within ISO MGI:1861933|MGI:2384509|MGI:2652160 (MGI:3033881|PMID:9432982), (MGI:79110|PMID:8598040), (MGI:79111|PMID:8598041), (MGI:79272|PMID:8638109) RGD PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 MGI:3033881 MGI:79110 MGI:79111 MGI:79272 NCBI chr20:4,707,028...4,710,432 JBrowse link
G Xbp1 X-box binding protein 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:11460154)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713 JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447|MGI:3526403 (MGI:893249|PMID:9208839)
(PMID:7630421)
RGD PMID:7630421 PMID:9208839 MGI:893249 NCBI chr 9:38,989,750...39,011,701 JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5300225|PMID:22201126) RGD PMID:22201126 MGI:5300225 NCBI chr 6:95,096,838...95,125,811 JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 involved_in ISO (MGI:5790022|PMID:26522984) RGD PMID:26522984 MGI:5790022 NCBI chr16:1,027,083...1,232,616 JBrowse link
positive regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:3620422|PMID:12163459), (MGI:3640996|PMID:11435465), (MGI:3690682|PMID:11067867), (MGI:3774231|PMID:16670300) RGD PMID:11067867 PMID:11435465 PMID:12163459 PMID:16670300 MGI:3620422 MGI:3640996 MGI:3690682 MGI:3774231 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (MGI:4836302|PMID:20856819) RGD PMID:20856819 MGI:4836302 NCBI chr 1:194,776,559...194,789,330 JBrowse link
G Egr3 early growth response 3 acts_upstream_of_or_within ISO (MGI:5139961|PMID:21737317) RGD PMID:21737317 MGI:5139961 NCBI chr15:45,150,335...45,156,052 JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532 JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455|MGI:2429736 (MGI:1095961|PMID:9252128), (MGI:1327709|PMID:9916699) RGD PMID:9252128 PMID:9916699 MGI:1095961 MGI:1327709 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:1857198 (MGI:893320|PMID:9215626) RGD PMID:9215626 MGI:893320 NCBI chr 2:58,452,393...58,477,757 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:1891792|PMID:11017103) RGD PMID:11017103 MGI:1891792 NCBI chr 3:104,168,549...104,230,107 JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3836494|PMID:19109233)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19109233 GO_REF:0000024 GO_REF:0000107 MGI:3836494 NCBI chr 4:6,954,017...6,963,170 JBrowse link
G Vnn1 vanin 1 involved_in ISO (MGI:84472|PMID:8934567) RGD PMID:8934567 MGI:84472 NCBI chr 1:21,537,084...21,547,395 JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17008549)
UniProt
RGD
PMID:17008549, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205 JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:96,280,335...96,285,750 JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:2176424 NCBI chr 5:29,630,806...29,662,804 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644 JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr18:58,942,282...58,996,318 JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:4436838 NCBI chr 1:153,854,029...153,854,123 JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 1:85,679,353...85,690,415 JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr11:44,782,676...44,810,723 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO
PMID:21873635
(MGI:3851279|PMID:19501566)
RGD PMID:19501566, PMID:21873635 MGI:3851279, RGD:13792537 NCBI chr 7:721,809...723,923 JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:180,115,061...180,139,981 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814 JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386 JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:83,883,490...83,928,932 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:4943387 NCBI chr13:73,723,329...73,746,809 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:15,939,771...15,973,367 JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (MGI:5617929|PMID:24645804) RGD PMID:24645804 MGI:5617929 NCBI chr 5:59,678,066...59,785,443 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    immune system process 2910
      leukocyte activation 1070
        lymphocyte activation 884
          lymphocyte differentiation 424
            positive regulation of lymphocyte differentiation 115
              positive regulation of B cell differentiation + 17
              positive regulation of T cell differentiation + 99
              positive regulation of natural killer cell differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 19492
    developmental process 6768
      anatomical structure development 6195
        multicellular organism development 5632
          system development 5300
            animal organ development 4060
              hematopoietic or lymphoid organ development 1028
                hemopoiesis 976
                  leukocyte differentiation 611
                    mononuclear cell differentiation 476
                      lymphocyte differentiation 424
                        regulation of lymphocyte differentiation 200
                          positive regulation of lymphocyte differentiation 115
                            positive regulation of B cell differentiation + 17
                            positive regulation of T cell differentiation + 99
                            positive regulation of natural killer cell differentiation + 11
paths to the root