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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis
 xref: Reactome:R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)"

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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chrNW_004624760:880,216...898,753
Ensembl chrNW_004624760:880,148...898,751 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within ISO (PMID:16455790) MGI PMID:16455790 NCBI chrNW_004624738:3,579,747...3,622,508
Ensembl chrNW_004624738:3,580,033...3,620,192 		JBrowse link
G Aqp8 aquaporin 8 involved_in ISO (PMID:30579780) UniProt PMID:30579780 NCBI chrNW_004624782:10,074,875...10,082,628
Ensembl chrNW_004624782:10,075,062...10,082,076 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chrNW_004624767:16,118,157...16,132,225
Ensembl chrNW_004624767:16,118,052...16,132,834 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) ComplexPortal PMID:24217618 NCBI chrNW_004624737:11,977,397...12,018,437
Ensembl chrNW_004624737:11,977,397...12,018,438 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) ComplexPortal PMID:24217618 NCBI chrNW_004624780:5,844,473...5,861,493
Ensembl chrNW_004624780:5,843,141...5,862,039 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624740:26,585,913...26,603,517
Ensembl chrNW_004624740:26,586,517...26,603,517 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (PMID:29395055) UniProt PMID:29395055 NCBI chrNW_004624860:3,611,300...3,642,682
Ensembl chrNW_004624860:3,611,300...3,642,686 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (PMID:14673138) MGI PMID:14673138 NCBI chrNW_004624744:14,227,430...14,245,082
Ensembl chrNW_004624744:14,240,570...14,245,183 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:16054043) MGI
TreeGrafter		 PMID:16054043 GO_REF:0000118 NCBI chrNW_004624730:73,926,978...73,975,337
Ensembl chrNW_004624730:73,927,010...73,975,337 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL		 PMID:1917954 PMID:9225228 RGD:10059686 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G Chlsn cholesin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624740:26,552,102...26,671,059
Ensembl chrNW_004624740:26,549,264...26,662,409 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004624737:11,977,397...12,018,437
Ensembl chrNW_004624737:11,977,397...12,018,438 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004624780:5,844,473...5,861,493
Ensembl chrNW_004624780:5,843,141...5,862,039 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chrNW_004624800:2,533,010...2,543,754
Ensembl chrNW_004624800:2,534,967...2,543,075 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17916878) BHF-UCL PMID:17916878 NCBI chrNW_004624745:28,137,140...28,188,670
Ensembl chrNW_004624745:28,104,744...28,188,704 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in ISO (PMID:17916878) BHF-UCL PMID:17916878 NCBI chrNW_004624784:14,529,957...14,545,125
Ensembl chrNW_004624784:14,529,976...14,545,246 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chrNW_004624885:942,998...949,529
Ensembl chrNW_004624885:943,571...949,528 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISO (PMID:19229075) BHF-UCL PMID:19229075 NCBI chrNW_004624774:1,779,168...1,867,321
Ensembl chrNW_004624774:1,779,170...1,867,300 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004624739:28,995,173...29,074,354
Ensembl chrNW_004624739:28,995,179...29,073,813 		JBrowse link
G LOC101701685 cholesterol 7-alpha-monooxygenase involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chrNW_004624744:33,563,564...33,619,851
Ensembl chrNW_004624744:33,612,901...33,619,869 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mbtps2 membrane bound transcription factor peptidase, site 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624829:6,795,563...6,839,416
Ensembl chrNW_004624829:6,795,528...6,834,604 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:32976883 RGD:405096663 NCBI chrNW_004624758:13,542,467...13,545,106
Ensembl chrNW_004624758:13,536,493...13,545,599 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chrNW_004624757:12,140,041...12,303,568
Ensembl chrNW_004624757:12,138,681...12,159,661 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISO (PMID:33942715) UniProt PMID:33942715 NCBI chrNW_004624785:15,738,231...15,845,051
Ensembl chrNW_004624785:15,739,187...15,845,024 		JBrowse link
G Scap SREBF chaperone involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chrNW_004624730:73,926,978...73,975,337
Ensembl chrNW_004624730:73,927,010...73,975,337 		JBrowse link
G Scp2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chrNW_004624859:106,405...252,870
Ensembl chrNW_004624859:107,258...252,756 		JBrowse link
G Sec14l2 SEC14 like lipid binding 2 ISO RGD PMID:11226224 RGD:727312 NCBI chrNW_004624747:6,719,549...6,742,794
Ensembl chrNW_004624747:6,719,498...6,742,794 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within 		ISO (PMID:12177166), (PMID:32322062)
(PMID:8833906), (PMID:9062341)
(PMID:16046411)
(PMID:9329978) 		UniProt
MGI		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 More... NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:12177166), (PMID:32322062), (PMID:38503280)
(PMID:33942715), (PMID:34021134) 		UniProt PMID:12177166 PMID:32322062 PMID:33942715 PMID:34021134 PMID:38503280 NCBI chrNW_004624752:6,815,075...6,871,674
Ensembl chrNW_004624752:6,816,468...6,871,567 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      metabolic process 10996
        biosynthetic process 7897
          regulation of biosynthetic process 4796
            regulation of alcohol biosynthetic process 60
              regulation of cholesterol biosynthetic process 29
                negative regulation of cholesterol biosynthetic process 5
                positive regulation of cholesterol biosynthetic process 17
Path 2
Term Annotations click to browse term
  biological_process 17647
    biological regulation 11839
      regulation of biological process 11484
        regulation of cellular process 11155
          regulation of metabolic process 5929
            regulation of primary metabolic process 4964
              regulation of lipid metabolic process 347
                regulation of steroid metabolic process 113
                  regulation of steroid biosynthetic process 87
                    regulation of sterol biosynthetic process 29
                      regulation of cholesterol biosynthetic process 29
                        negative regulation of cholesterol biosynthetic process 5
                        positive regulation of cholesterol biosynthetic process 17
paths to the root