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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis
 xref: Reactome:R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)"


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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP-binding cassette, sub-family A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 2:25,318,611...25,338,556
Ensembl chr 2:25,318,715...25,338,552 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within IMP (PMID:16455790) MGI PMID:16455790 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Aqp8 aquaporin 8 involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO RGD
GO_Central		 PMID:10329655 GO_REF:0000096 RGD:632010 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:139,363,452...139,382,170
Ensembl chr 5:139,363,452...139,382,170 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in IMP (PMID:29395055) UniProt PMID:29395055 NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within IMP (PMID:14673138) MGI PMID:14673138 NCBI chr 3:5,625,248...5,643,655
Ensembl chr 3:5,625,248...5,641,299 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within
involved_in 		IMP
IBA 		(PMID:16054043) MGI
GO_Central		 PMID:16054043 GO_REF:0000033 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO
IEA 		RGD
GO_Central
Ensembl		 PMID:9225228 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:10059686 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Chlsn cholesin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:139,345,494...139,446,291
Ensembl chr 5:139,345,494...139,446,282 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within IMP (PMID:17202134) MGI PMID:17202134 NCBI chr13:9,002,899...9,010,981
Ensembl chr13:9,002,899...9,010,981 		JBrowse link
G Insig1 insulin induced gene 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24296663)
(PMID:23951060) 		BHF-UCL PMID:23951060 PMID:24296663 NCBI chr16:18,145,265...18,145,329
Ensembl chr16:18,145,265...18,145,329 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) BHF-UCL PMID:23951060 NCBI chr12:108,624,879...108,624,977
Ensembl chr12:108,624,879...108,624,977 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) BHF-UCL PMID:30195495 NCBI chr  X:150,696,210...150,696,317
Ensembl chr  X:150,696,210...150,696,317 		JBrowse link
G Sod1 superoxide dismutase 1, soluble involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IMP (PMID:17916878) BHF-UCL PMID:17916878 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in IMP (PMID:17916878) BHF-UCL PMID:17916878 NCBI chr 9:44,184,485...44,199,953
Ensembl chr 9:44,184,485...44,199,912 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000096 GO_REF:0000107 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Fdps farnesyl diphosphate synthetase involved_in ISO RGD
GO_Central		 PMID:18637708 GO_REF:0000096 RGD:2316295 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:156,330,818...156,381,711
Ensembl chr  X:156,318,367...156,381,711 		JBrowse link
G Mir182 microRNA 182 involved_in ISO (PMID:23823476) BHF-UCL PMID:23823476 NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991 		JBrowse link
G Mir96 microRNA 96 involved_in
acts_upstream_of 		ISO (PMID:23823476)
(PMID:30460077) 		BHF-UCL PMID:23823476 PMID:30460077 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 involved_in ISO RGD
GO_Central		 PMID:32976883 GO_REF:0000096 RGD:405096663 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member III involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:97,229,223...97,259,608
Ensembl chr 5:97,230,188...97,259,455 		JBrowse link
G Por cytochrome p450 oxidoreductase involved_in ISO GO_Central GO_REF:0000096 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Qki quaking, KH domain containing RNA binding involved_in IMP (PMID:33942715) UniProt PMID:33942715 NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783 		JBrowse link
G Scap SREBF chaperone involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
G Scp2 sterol carrier protein 2, liver involved_in ISO RGD
GO_Central		 PMID:2554812 GO_REF:0000096 RGD:9850260 NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 involved_in ISO RGD
GO_Central		 PMID:11226224 GO_REF:0000096 RGD:727312 NCBI chr11:4,047,039...4,068,729
Ensembl chr11:4,047,039...4,073,415 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within
involved_in 		IMP
ISS
ISO
IDA 		(PMID:9329978)
(PMID:16046411)
(PMID:8833906), (PMID:9062341) 		MGI
UniProt
GO_Central		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:16046411 GO_REF:0000024 GO_REF:0000119 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 involved_in IMP
ISO
ISS
IEA 		(PMID:33942715), (PMID:34021134) UniProt
GO_Central
Ensembl		 PMID:33942715 PMID:34021134 GO_REF:0000024 GO_REF:0000107 GO_REF:0000119 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28625
    cellular process 18393
      metabolic process 11623
        biosynthetic process 8310
          regulation of biosynthetic process 5728
            regulation of alcohol biosynthetic process 68
              regulation of cholesterol biosynthetic process 37
                negative regulation of cholesterol biosynthetic process 10
                positive regulation of cholesterol biosynthetic process 20
Path 2
Term Annotations click to browse term
  biological_process 28625
    biological regulation 13469
      regulation of biological process 13028
        regulation of cellular process 12646
          regulation of metabolic process 6959
            regulation of primary metabolic process 5768
              regulation of lipid metabolic process 428
                regulation of steroid metabolic process 143
                  regulation of steroid biosynthetic process 113
                    regulation of sterol biosynthetic process 37
                      regulation of cholesterol biosynthetic process 37
                        negative regulation of cholesterol biosynthetic process 10
                        positive regulation of cholesterol biosynthetic process 20
paths to the root