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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis


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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 NOT|involved_in IDA (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,922
JBrowse link
G APOB apolipoprotein B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3652707|PMID:16455790) Ensembl
MGI
PMID:16455790 GO_REF:0000107 MGI:3652707 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G DHCR7 7-dehydrocholesterol reductase involved_in IEA
ISO
Ensembl
RGD
PMID:10329655 GO_REF:0000107 RGD:632010 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in ISS UniProt GO_REF:0000024 NCBI chr12:6,976,185...7,018,508
Ensembl chr12:6,976,185...7,018,477
JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in TAS Reactome Reactome:R-HSA-1655829 NCBI chr16:84,053,763...84,116,942
Ensembl chr16:84,053,761...84,116,942
JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in TAS Reactome Reactome:R-HSA-1655829 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423
JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (MGI:3027293|PMID:14673138) MGI PMID:14673138 MGI:3027293 NCBI chr 8:76,980,258...77,001,044
Ensembl chr 8:76,980,258...77,001,044
JBrowse link
G SCAP SREBF chaperone acts_upstream_of_or_within ISO (MGI:3770209|PMID:16054043) MGI PMID:16054043 MGI:3770209 NCBI chr 3:47,413,681...47,477,126
Ensembl chr 3:47,413,681...47,477,126
JBrowse link
G SEC14L2 SEC14 like lipid binding 2 involved_in NAS (PMID:11226224) UniProt PMID:11226224 NCBI chr22:30,397,018...30,425,303
Ensembl chr22:30,396,941...30,425,303
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IDA
ISO
(PMID:1917954) BHF-UCL
RGD
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr10:100,150,094...100,186,029
Ensembl chr10:100,150,094...100,186,033
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,736,627...37,758,422
Ensembl chr 8:37,736,601...37,758,422
JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) MGI PMID:17202134 MGI:5490819 NCBI chr10:1,018,910...1,025,859
Ensembl chr10:1,018,910...1,025,859
JBrowse link
G SCAP SREBF chaperone involved_in NAS (PMID:11969205) UniProt PMID:11969205 NCBI chr 3:47,413,681...47,477,126
Ensembl chr 3:47,413,681...47,477,126
JBrowse link
G SOD1 superoxide dismutase 1 involved_in IDA (PMID:15473258) UniProt PMID:15473258 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G FDPS farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chr 1:155,308,801...155,320,665
Ensembl chr 1:155,308,748...155,320,666
JBrowse link
G FGF1 fibroblast growth factor 1 involved_in IDA (PMID:19229075) BHF-UCL PMID:19229075 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G POR cytochrome p450 oxidoreductase involved_in IEA
ISO
Ensembl
RGD
PMID:19264869 GO_REF:0000107 RGD:2316785 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 involved_in NAS (PMID:8557660) UniProt PMID:8557660 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,379...40,798,374
JBrowse link
G SCAP SREBF chaperone involved_in IDA (PMID:32322062) UniProt PMID:32322062 NCBI chr 3:47,413,681...47,477,126
Ensembl chr 3:47,413,681...47,477,126
JBrowse link
G SCP2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698
JBrowse link
G SEC14L2 SEC14 like lipid binding 2 ISO RGD PMID:11226224 RGD:727312 NCBI chr22:30,397,018...30,425,303
Ensembl chr22:30,396,941...30,425,303
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within
IDA
ISO
IEA
(PMID:32322062)
(MGI:3603730|PMID:16046411)
(MGI:1098057|PMID:9329978)
UniProt
MGI
Ensembl
PMID:9329978 PMID:16046411 PMID:32322062 GO_REF:0000107 MGI:1098057 MGI:3603730 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in IDA (PMID:32322062) UniProt PMID:32322062 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    regulation of biological process 12367
      regulation of metabolic process 7180
        regulation of small molecule metabolic process 394
          regulation of alcohol biosynthetic process 56
            regulation of cholesterol biosynthetic process 23
              negative regulation of cholesterol biosynthetic process 6
              positive regulation of cholesterol biosynthetic process 11
Path 2
Term Annotations click to browse term
  biological_process 18537
    biological regulation 13081
      regulation of biological process 12367
        regulation of metabolic process 7180
          regulation of primary metabolic process 6067
            regulation of lipid metabolic process 392
              regulation of lipid biosynthetic process 200
                regulation of steroid biosynthetic process 84
                  regulation of sterol biosynthetic process 23
                    regulation of cholesterol biosynthetic process 23
                      negative regulation of cholesterol biosynthetic process 6
                      positive regulation of cholesterol biosynthetic process 11
paths to the root