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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis
 xref: Reactome:R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)"

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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr12:1,161,340...1,183,807
Ensembl chr12:1,162,865...1,183,113 		JBrowse link
G APOB apolipoprotein B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:86,624,209...86,669,175
Ensembl chr14:86,624,332...86,668,704 		JBrowse link
G AQP8 aquaporin 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:22,928,230...22,940,814
Ensembl chr 5:22,928,350...22,940,856 		JBrowse link
G DHCR7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chr 1:3,243,263...3,257,332
Ensembl chr 1:3,243,313...3,257,487 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,181,320...93,217,967
Ensembl chr 9:93,181,319...93,217,034 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:35,771,541...35,789,848
Ensembl chr 8:35,771,580...35,789,345 		JBrowse link
G GPR146 G protein-coupled receptor 146 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:20,522,155...20,538,402
Ensembl chr28:20,522,899...20,523,900 		JBrowse link
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:7,009,911...7,051,391
Ensembl chr11:7,005,701...7,051,605 		JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (PMID:14673138) MGI PMID:14673138 NCBI chr 8:72,513,975...72,532,399
Ensembl chr 8:72,514,307...72,517,003 		JBrowse link
G SCAP SREBF chaperone involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr22:8,821,809...8,887,538
Ensembl chr22:8,818,980...8,850,202 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO
IEA 		RGD
Ensembl		 PMID:9225228 GO_REF:0000107 RGD:10059686 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G CHLSN cholesin involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:20,452,734...20,575,087
Ensembl chr28:20,452,748...20,575,450 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,181,320...93,217,967
Ensembl chr 9:93,181,319...93,217,034 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:35,771,541...35,789,848
Ensembl chr 8:35,771,580...35,789,345 		JBrowse link
G INSIG1 insulin induced gene 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,448,614...123,460,778
Ensembl chr21:123,449,106...123,460,807 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17916878) BHF-UCL PMID:17916878 NCBI chr 2:86,098,818...86,176,101
Ensembl chr 2:86,099,414...86,179,949 		JBrowse link
G ABCG4 ATP binding cassette subfamily G member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,522,773...110,537,747
Ensembl chr 1:110,524,900...110,537,735 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 8:54,475,801...54,489,329
Ensembl chr 8:54,477,105...54,485,649 		JBrowse link
G FDPS farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chr20:8,514,311...8,526,363 JBrowse link
G FGF1 fibroblast growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:45,220,827...45,328,387
Ensembl chr23:45,220,800...45,328,328 		JBrowse link
G GNAI1 G protein subunit alpha i1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:68,687,809...68,770,415
Ensembl chr21:68,687,307...68,770,360 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:20,319,731...20,364,603
Ensembl chr  X:20,319,807...20,361,847 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO RGD PMID:32976883 RGD:405096663 NCBI chr 7:109,774,700...109,794,543
Ensembl chr 7:109,774,918...109,776,905 		JBrowse link
G PAQR3 progestin and adipoQ receptor family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,358,443...27,385,612
Ensembl chr 7:27,367,059...27,385,568 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chr 6:12,743,752...12,759,155 JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:12,727,643...12,758,915 JBrowse link
G QKI QKI, KH domain containing RNA binding involved_in ISO (PMID:33942715) UniProt PMID:33942715 NCBI chr13:91,045,167...91,206,190
Ensembl chr13:91,045,209...91,208,471 		JBrowse link
G SCAP SREBF chaperone involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:8,821,809...8,887,538
Ensembl chr22:8,818,980...8,850,202 		JBrowse link
G SCP2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chr20:79,868,825...79,993,906
Ensembl chr20:79,865,332...79,993,835 		JBrowse link
G SEC14L2 SEC14 like lipid binding 2 ISO RGD PMID:11226224 RGD:727312 NCBI chr19:13,276,712...13,302,737
Ensembl chr19:13,276,913...13,305,003 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:24,364,725...24,439,851
Ensembl chr19:24,364,911...24,440,014 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19826
    cellular process 19340
      metabolic process 13108
        biosynthetic process 9902
          regulation of biosynthetic process 5420
            regulation of alcohol biosynthetic process 63
              regulation of cholesterol biosynthetic process 30
                negative regulation of cholesterol biosynthetic process 5
                positive regulation of cholesterol biosynthetic process 18
Path 2
Term Annotations click to browse term
  biological_process 19826
    biological regulation 12155
      regulation of biological process 11760
        regulation of cellular process 11395
          regulation of metabolic process 6642
            regulation of primary metabolic process 5263
              regulation of lipid metabolic process 375
                regulation of steroid metabolic process 120
                  regulation of steroid biosynthetic process 93
                    regulation of sterol biosynthetic process 30
                      regulation of cholesterol biosynthetic process 30
                        negative regulation of cholesterol biosynthetic process 5
                        positive regulation of cholesterol biosynthetic process 18
paths to the root