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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol biosynthetic process
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Accession:GO:0045540 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
Synonyms:exact_synonym: regulation of cholesterol anabolism;   regulation of cholesterol biosynthesis;   regulation of cholesterol formation;   regulation of cholesterol synthesis
 xref: Reactome:R-HSA-1655829 "Regulation of cholesterol biosynthesis by SREBP (SREBF)"


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regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within ISO
IEA 		MGI:2183298 (PMID:16455790)
GO_REF:0000107 		RGD
Ensembl		 PMID:16455790 GO_REF:0000107 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Aqp8 aquaporin 8 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:30579780)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:30579780 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Cyp51 cytochrome P450, family 51 TAS RGD PMID:7665087 RGD:1298863 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase IDA RGD PMID:10329655 RGD:632010 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA 		(PMID:24217618)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217618 GO_REF:0000107 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in ISO
IEA 		(PMID:38503280)
GO_REF:0000107 		RGD
Ensembl		 PMID:38503280 GO_REF:0000107 NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:29395055) 		UniProt
RGD		 PMID:29395055 GO_REF:0000024 NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Mvk mevalonate kinase NAS RGD PMID:2158094 RGD:728935 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (PMID:14673138) RGD PMID:14673138 NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Scap SREBF chaperone involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:2148743|MGI:2180899 (PMID:16054043) 		GO_Central
Ensembl
RGD		 PMID:16054043 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IDA
IEA
ISO 		GO_REF:0000107
(PMID:1917954) 		Ensembl
RGD		 PMID:1917954 PMID:9225228 GO_REF:0000107, RGD:10059686 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Chlsn cholesin involved_in ISO (PMID:38503280) RGD PMID:38503280 NCBI chr12:15,185,728...15,289,042
Ensembl chr12:15,185,707...15,289,069 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA 		(PMID:24217618)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217618 GO_REF:0000107 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (PMID:17202134) RGD PMID:17202134 NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) RGD PMID:26311497 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:23951060), (PMID:24296663) RGD PMID:23951060 PMID:24296663 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) RGD PMID:23951060 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) RGD PMID:30195495 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO
IEA 		(PMID:17916878)
GO_REF:0000107 		RGD
Ensembl		 PMID:17916878 GO_REF:0000107 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:17916878) 		Ensembl
RGD		 PMID:17916878 GO_REF:0000107 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in IDA PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:18637708 RGD:2316295 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:19229075) 		UniProt
RGD		 PMID:19229075 GO_REF:0000024 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in ISO (PMID:38503280) RGD PMID:38503280 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:38503280) 		Ensembl
RGD		 PMID:38503280 GO_REF:0000107 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in ISO
IEA 		(PMID:11163209)
GO_REF:0000107 		RGD
Ensembl		 PMID:11163209 GO_REF:0000107 NCBI chr  X:37,410,914...37,461,130
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
G Mir182 microRNA 182 involved_in ISO RNAcentral:URS000016FF9C_9606 (PMID:23823476) RGD PMID:23823476 NCBI chr 4:58,784,818...58,784,879
Ensembl chr 4:58,784,818...58,784,879 		JBrowse link
G Mir96 microRNA 96 involved_in
acts_upstream_of 		ISO RNAcentral:URS00001CC379_9606 (PMID:23823476)
(PMID:30460077) 		RGD PMID:23823476 PMID:30460077 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IMP RGD PMID:32976883 RGD:405096663 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO
IEA 		(PMID:26311497)
GO_REF:0000107 		RGD
Ensembl		 PMID:26311497 GO_REF:0000107 NCBI chr14:12,462,568...12,484,999
Ensembl chr14:12,462,563...12,479,994 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in IEA
ISO 		GO_REF:0000107
(PMID:38503280) 		Ensembl
RGD		 PMID:38503280 GO_REF:0000107 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISO (PMID:33942715) RGD PMID:33942715 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:50,387,698...50,498,831 		JBrowse link
G Scap SREBF chaperone involved_in ISO
IEA 		(PMID:32322062)
GO_REF:0000107 		RGD
Ensembl		 PMID:32322062 GO_REF:0000107 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Scp2 sterol carrier protein 2 IDA RGD PMID:2554812 RGD:9850260 NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:122,776,549...122,881,287 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 IDA RGD PMID:11226224 RGD:727312 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within 		ISO
ISS
IEA 		(PMID:12177166)
(PMID:32322062)
GO_REF:0000024
MGI:2177958|MGI:2177959 (PMID:16046411), (PMID:9329978)
(PMID:8833906), (PMID:9062341)
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:32322062)
GO_REF:0000024
(PMID:12177166), (PMID:38503280)
(PMID:33942715), (PMID:34021134) 		Ensembl
RGD
UniProt		 PMID:12177166 PMID:32322062 PMID:33942715 PMID:34021134 PMID:38503280 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Yy2 YY2 transcription factor involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:37,438,425...37,442,047
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        biosynthetic process 8630
          regulation of biosynthetic process 5581
            regulation of alcohol biosynthetic process 69
              regulation of cholesterol biosynthetic process 38
                negative regulation of cholesterol biosynthetic process 9
                positive regulation of cholesterol biosynthetic process 20
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          regulation of metabolic process 6776
            regulation of primary metabolic process 5625
              regulation of lipid metabolic process 398
                regulation of steroid metabolic process 133
                  regulation of steroid biosynthetic process 103
                    regulation of sterol biosynthetic process 38
                      regulation of cholesterol biosynthetic process 38
                        negative regulation of cholesterol biosynthetic process 9
                        positive regulation of cholesterol biosynthetic process 20
paths to the root