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ONTOLOGY REPORT - ANNOTATIONS

Term:endothelial cell differentiation
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Accession:GO:0045446 term browser browse the term
Definition:The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

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endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Barx1 BARX homeobox 1 acts_upstream_of_or_within ISO (PMID:15809042) MGI PMID:15809042 NCBI chrNW_004955515:4,230,713...4,234,189
Ensembl chrNW_004955515:4,229,783...4,234,191 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO RGD PMID:24955809 RGD:11352686 NCBI chrNW_004955440:3,456,165...3,460,024
Ensembl chrNW_004955440:3,455,153...3,460,109 		JBrowse link
G Fstl1 follistatin like 1 involved_in ISO (MGI:4457221|PMID:20054002) UniProt PMID:20054002 MGI:4457221 NCBI chrNW_004955427:19,952,823...20,003,832
Ensembl chrNW_004955427:19,952,853...20,004,241 		JBrowse link
G Fzd2 frizzled class receptor 2 acts_upstream_of_or_within ISO (PMID:15809042) MGI PMID:15809042 NCBI chrNW_004955451:17,501,410...17,503,726 JBrowse link
G Fzd4 frizzled class receptor 4 acts_upstream_of_or_within ISO (PMID:23217714) MGI PMID:23217714 NCBI chrNW_004955414:6,094,585...6,103,910
Ensembl chrNW_004955414:6,094,585...6,098,865 		JBrowse link
G Hoxb5 homeobox B5 acts_upstream_of_or_within ISO (PMID:12897140) MGI PMID:12897140 NCBI chrNW_004955451:12,637,229...12,650,261
Ensembl chrNW_004955451:12,637,822...12,650,261 		JBrowse link
G Kdm6b lysine demethylase 6B involved_in ISO (MGI:5574281|PMID:23856522) BHF-UCL PMID:23856522 MGI:5574281 NCBI chrNW_004955467:9,085,239...9,106,658
Ensembl chrNW_004955467:9,086,204...9,094,404 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (PMID:18772315)
(PMID:12897140)		 MGI PMID:12897140 PMID:18772315 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO (PMID:23217714) MGI PMID:23217714 NCBI chrNW_004955516:4,218,703...4,244,774
Ensembl chrNW_004955516:4,218,703...4,244,846 		JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:10964583 RGD:1304484 NCBI chrNW_004955437:658,076...679,338 JBrowse link
G Ptn pleiotrophin ISO RGD PMID:20830586 RGD:9686141 NCBI chrNW_004955494:5,580,264...5,681,848
Ensembl chrNW_004955494:5,580,422...5,684,190 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:7959012 RGD:61573 NCBI chrNW_004955435:5,880,266...5,882,823
Ensembl chrNW_004955435:5,880,288...5,881,436 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of ISO (PMID:25186293) MGI PMID:25186293 NCBI chrNW_004955561:1,573,525...1,578,295
Ensembl chrNW_004955561:1,573,525...1,580,511 		JBrowse link
arterial endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004955444:1,498,444...1,502,099
Ensembl chrNW_004955444:1,498,675...1,500,945 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004955436:7,060,930...7,070,610
Ensembl chrNW_004955436:7,060,930...7,070,030 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO (PMID:22783020) MGI PMID:22783020 NCBI chrNW_004955451:6,982,094...6,988,345
Ensembl chrNW_004955451:6,985,277...6,988,345 		JBrowse link
arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004955443:18,783,061...19,029,441
Ensembl chrNW_004955443:18,783,061...18,910,228 		JBrowse link
blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO (PMID:19151727) MGI PMID:19151727 NCBI chrNW_004955456:7,232,224...7,251,012
Ensembl chrNW_004955456:7,227,667...7,256,206 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:15107403) MGI PMID:15107403 NCBI chrNW_004955444:1,498,444...1,502,099
Ensembl chrNW_004955444:1,498,675...1,500,945 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:15107403) MGI PMID:15107403 NCBI chrNW_004955436:7,060,930...7,070,610
Ensembl chrNW_004955436:7,060,930...7,070,030 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (PMID:15644447) MGI PMID:15644447 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:33357458) MGI PMID:33357458 NCBI chrNW_004955425:3,718,291...3,755,942
Ensembl chrNW_004955425:3,718,206...3,756,142 		JBrowse link
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO (PMID:11927535) MGI PMID:11927535 NCBI chrNW_004955406:3,715,140...3,770,019
Ensembl chrNW_004955406:3,719,972...3,770,555 		JBrowse link
blood vessel endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004955443:18,783,061...19,029,441
Ensembl chrNW_004955443:18,783,061...18,910,228 		JBrowse link
endocardial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Nrg1 neuregulin 1 involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116 		JBrowse link
G Smad4 SMAD family member 4 involved_in ISO (MGI:4946551|PMID:21330551) BHF-UCL PMID:21330551 MGI:4946551 NCBI chrNW_004955402:35,956,080...36,001,746
Ensembl chrNW_004955402:35,961,165...35,994,538 		JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (PMID:17610846) MGI PMID:17610846 NCBI chrNW_004955454:13,689,403...13,690,019 JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO (PMID:17610846) MGI PMID:17610846 NCBI chrNW_004955528:204,729...206,772 JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:19506109) BHF-UCL PMID:19506109 NCBI chrNW_004955449:15,587,958...15,706,432
Ensembl chrNW_004955449:15,640,230...15,708,694 		JBrowse link
endothelial cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO (PMID:19151727) MGI PMID:19151727 NCBI chrNW_004955456:7,232,224...7,251,012
Ensembl chrNW_004955456:7,227,667...7,256,206 		JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within ISO (PMID:16373599) MGI PMID:16373599 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G Heg1 heart development protein with EGF like domains 1 acts_upstream_of_or_within ISO (PMID:19151727) MGI PMID:19151727 NCBI chrNW_004955427:24,035,193...24,115,483 JBrowse link
G Vezf1 vascular endothelial zinc finger 1 acts_upstream_of_or_within ISO (PMID:15882861) MGI PMID:15882861 NCBI chrNW_004955451:5,014,310...5,031,080
Ensembl chrNW_004955451:5,014,218...5,032,225 		JBrowse link
endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa13 homeobox A13 acts_upstream_of_or_within ISO (PMID:18483557) MGI PMID:18483557 NCBI chrNW_004955410:28,887,952...28,893,515
Ensembl chrNW_004955410:28,890,171...28,893,515 		JBrowse link
endothelial cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 acts_upstream_of_or_within ISO (PMID:23372835) MGI PMID:23372835 NCBI chrNW_004955448:5,494,571...5,627,107
Ensembl chrNW_004955448:5,494,571...5,627,107 		JBrowse link
G Clic4 chloride intracellular channel 4 acts_upstream_of_or_within ISO (PMID:19197003) MGI PMID:19197003 NCBI chrNW_004955452:4,479,783...4,534,115
Ensembl chrNW_004955452:4,479,783...4,534,115 		JBrowse link
G Cnmd chondromodulin acts_upstream_of_or_within ISO (PMID:12714610) MGI PMID:12714610 NCBI chrNW_004955404:50,864,017...50,889,249
Ensembl chrNW_004955404:50,863,651...50,889,249 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain acts_upstream_of_or_within ISO (PMID:15188432) MGI PMID:15188432 NCBI chrNW_004955407:42,091,211...42,131,343
Ensembl chrNW_004955407:42,091,211...42,131,343 		JBrowse link
G Heg1 heart development protein with EGF like domains 1 acts_upstream_of_or_within ISO (PMID:19151727) MGI PMID:19151727 NCBI chrNW_004955427:24,035,193...24,115,483 JBrowse link
G Hoxa13 homeobox A13 acts_upstream_of_or_within ISO (PMID:18483557) MGI PMID:18483557 NCBI chrNW_004955410:28,887,952...28,893,515
Ensembl chrNW_004955410:28,890,171...28,893,515 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein acts_upstream_of_or_within ISO (PMID:17717145) MGI PMID:17717145 NCBI chrNW_004955422:29,337,969...29,339,178
Ensembl chrNW_004955422:29,337,757...29,339,178 		JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO (PMID:21285373) MGI PMID:21285373 NCBI chrNW_004955497:1,338,959...1,454,788
Ensembl chrNW_004955497:1,338,904...1,455,122 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO (PMID:14500721) UniProt PMID:14500721 NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647 		JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:10964583 RGD:1304484 NCBI chrNW_004955437:658,076...679,338 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:17563397) MGI PMID:17563397 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Plod3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 acts_upstream_of_or_within ISO (PMID:16467571) MGI PMID:16467571 NCBI chrNW_004955456:16,082,424...16,090,773
Ensembl chrNW_004955456:16,082,437...16,093,389 		JBrowse link
G Stc1 stanniocalcin 1 involved_in ISO (PMID:14500721) UniProt PMID:14500721 NCBI chrNW_004955403:46,969,837...46,982,075
Ensembl chrNW_004955403:46,969,677...46,982,191 		JBrowse link
G Tnmd tenomodulin acts_upstream_of_or_within ISO (PMID:12714610) MGI PMID:12714610 NCBI chrNW_004955503:6,732,791...6,750,693
Ensembl chrNW_004955503:6,732,733...6,750,717 		JBrowse link
endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (MGI:5466218|PMID:22282195) UniProt PMID:22282195 MGI:5466218 NCBI chrNW_004955411:3,478,943...3,486,541
Ensembl chrNW_004955411:3,478,033...3,486,604 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 acts_upstream_of_or_within ISO (PMID:32369453) MGI PMID:32369453 NCBI chrNW_004955612:46,723...99,012
Ensembl chrNW_004955612:46,724...97,729 		JBrowse link
establishment of blood-nerve barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:9734405) MGI PMID:9734405 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Cldn1 claudin 1 ISO RGD PMID:22733753 RGD:11341802 NCBI chrNW_004955420:17,798,974...17,815,049
Ensembl chrNW_004955420:17,798,974...17,815,205 		JBrowse link
G Dmd dystrophin acts_upstream_of_or_within ISO (PMID:12673830) MGI PMID:12673830 NCBI chrNW_004955535:1,283,084...3,297,015
Ensembl chrNW_004955535:1,283,523...3,299,542 		JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 acts_upstream_of_or_within ISO (PMID:20181608) MGI PMID:20181608 NCBI chrNW_004955545:2,705,903...2,710,763
Ensembl chrNW_004955545:2,709,013...2,710,588 		JBrowse link
G Ren renin NOT|acts_upstream_of_or_within ISO (PMID:10617578) MGI PMID:10617578 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn5 claudin 5 involved_in ISO (PMID:24280217) AgBase PMID:24280217 NCBI chrNW_004955442:18,509,501...18,511,267
Ensembl chrNW_004955442:18,509,676...18,510,332 		JBrowse link
G Ednra endothelin receptor type A involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955404:29,394,253...29,425,358
Ensembl chrNW_004955404:29,394,164...29,425,358 		JBrowse link
G Ezr ezrin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004955439:3,701,722...3,740,345
Ensembl chrNW_004955439:3,703,013...3,740,345 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:20826780) UniProt PMID:20826780 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
G Hpse heparanase involved_in ISO (PMID:27026367) MGI PMID:27026367 NCBI chrNW_004955474:6,367,467...6,394,395
Ensembl chrNW_004955474:6,367,467...6,394,395 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Marveld2 MARVEL domain containing 2 involved_in ISO (PMID:23073616) UniProt PMID:23073616 NCBI chrNW_004955575:115,734...135,568
Ensembl chrNW_004955575:115,752...139,463 		JBrowse link
G Msn moesin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004955475:5,301,856...5,370,378
Ensembl chrNW_004955475:5,301,910...5,370,691 		JBrowse link
G Myadm myeloid associated differentiation marker involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004955604:280,977...284,381
Ensembl chrNW_004955604:280,977...284,381 		JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chrNW_004955414:18,765,591...18,826,717
Ensembl chrNW_004955414:18,735,822...18,827,236 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chrNW_004955446:7,914,326...9,252,527
Ensembl chrNW_004955446:8,211,877...9,252,653 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 involved_in ISO (PMID:7589563) ARUK-UCL PMID:7589563 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B involved_in
acts_upstream_of_or_within		 ISO (PMID:18586956)
(PMID:21907835)		 GO_Central
MGI		 PMID:18586956 PMID:21907835 NCBI chrNW_004955445:17,864,103...17,961,295
Ensembl chrNW_004955445:17,863,556...17,962,052 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004955435:15,090,521...15,171,397
Ensembl chrNW_004955435:15,150,827...15,171,397 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004955458:15,110,709...15,121,868
Ensembl chrNW_004955458:15,080,778...15,123,203 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004955513:1,224,418...1,328,176
Ensembl chrNW_004955513:1,226,205...1,315,922 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004955471:12,670,837...12,838,910
Ensembl chrNW_004955471:12,670,764...12,815,430 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004955500:6,655,056...6,674,311
Ensembl chrNW_004955500:6,655,056...6,674,311 		JBrowse link
G Rdx radixin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004955412:12,100,436...12,184,444
Ensembl chrNW_004955412:12,100,359...12,172,545 		JBrowse link
G Robo4 roundabout guidance receptor 4 involved_in ISO (PMID:30455415) UniProt PMID:30455415 NCBI chrNW_004955412:25,954,906...25,967,707
Ensembl chrNW_004955412:25,954,085...25,967,723 		JBrowse link
G Sox18 SRY-box transcription factor 18 involved_in ISO (PMID:18065521) UniProt PMID:18065521 NCBI chrNW_004955528:204,729...206,772 JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO RGD PMID:31027862 RGD:38549575 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
establishment of endothelial intestinal barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afdn afadin, adherens junction formation factor involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955439:14,324,910...14,428,846
Ensembl chrNW_004955439:14,326,793...14,428,850 		JBrowse link
G Cldn1 claudin 1 ISO RGD PMID:22684624 RGD:11341733 NCBI chrNW_004955420:17,798,974...17,815,049
Ensembl chrNW_004955420:17,798,974...17,815,205 		JBrowse link
G F11r F11 receptor involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955468:12,764,968...12,785,956
Ensembl chrNW_004955468:12,765,874...12,785,929 		JBrowse link
G Fasn fatty acid synthase acts_upstream_of_or_within ISO (PMID:25565205) MGI PMID:25565205 NCBI chrNW_004955506:1,063,002...1,079,939
Ensembl chrNW_004955506:1,063,002...1,079,939 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:10201790 RGD:11520782 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor acts_upstream_of_or_within ISO (PMID:22155109) MGI PMID:22155109 NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138 		JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S acts_upstream_of_or_within ISO (PMID:24385580) MGI PMID:24385580 NCBI chrNW_004955495:3,943,075...3,991,361
Ensembl chrNW_004955495:3,943,170...3,990,927 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955424:19,393,589...19,421,373
Ensembl chrNW_004955424:19,393,589...19,421,373 		JBrowse link
G Rab1b RAB1B, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955422:19,039,741...19,047,088
Ensembl chrNW_004955422:19,039,632...19,047,088 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955448:4,668,477...4,671,629 JBrowse link
G Rap2c RAP2C, member of RAS oncogene family involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955473:2,709,407...2,723,453
Ensembl chrNW_004955473:2,709,407...2,723,756 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955471:12,670,837...12,838,910
Ensembl chrNW_004955471:12,670,764...12,815,430 		JBrowse link
G Rapgef6 Rap guanine nucleotide exchange factor 6 NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955408:2,902,530...3,109,273
Ensembl chrNW_004955408:2,902,530...3,109,273 		JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955416:28,640,807...28,869,717
Ensembl chrNW_004955416:28,654,905...28,870,555 		JBrowse link
G Tjp2 tight junction protein 2 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004955434:3,781,368...3,923,240
Ensembl chrNW_004955434:3,781,113...3,923,391 		JBrowse link
lymphatic endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B involved_in ISO (MGI:4436974|PMID:19903896) BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004955427:25,438,652...25,467,360
Ensembl chrNW_004955427:25,438,652...25,467,360 		JBrowse link
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:19903896)
(MGI:4436974|PMID:19903896)		 BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004955547:2,278,548...2,293,865
Ensembl chrNW_004955547:2,279,042...2,294,443 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:4436974|PMID:19903896) BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004955457:12,235,780...12,315,680
Ensembl chrNW_004955457:12,235,780...12,316,727 		JBrowse link
G Prox1 prospero homeobox 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:12198161)
(PMID:19056883)		 BHF-UCL
MGI		 PMID:12198161 PMID:19056883 NCBI chrNW_004955406:3,715,140...3,770,019
Ensembl chrNW_004955406:3,719,972...3,770,555 		JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO (PMID:18931657) MGI PMID:18931657 NCBI chrNW_004955528:204,729...206,772 JBrowse link
G Tie1 tyrosine kinase with immunoglobulin like and EGF like domains 1 acts_upstream_of_or_within ISO (MGI:4439415|PMID:20223757) BHF-UCL PMID:20223757 MGI:4439415 NCBI chrNW_004955537:2,894,913...2,914,284
Ensembl chrNW_004955537:2,894,914...2,914,284 		JBrowse link
lymphatic endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr2f2 nuclear receptor subfamily 2 group F member 2 involved_in ISO (PMID:18815287) BHF-UCL PMID:18815287 NCBI chrNW_004955416:24,148,052...24,154,406
Ensembl chrNW_004955416:24,141,888...24,168,585 		JBrowse link
G Pdpn podoplanin involved_in ISO (MGI:4453945|PMID:20110424) UniProt PMID:20110424 MGI:4453945 NCBI chrNW_004955527:4,183,639...4,215,200 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:18815287) BHF-UCL PMID:18815287 NCBI chrNW_004955406:3,715,140...3,770,019
Ensembl chrNW_004955406:3,719,972...3,770,555 		JBrowse link
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj2 forkhead box J2 involved_in ISO (PMID:24792364) BHF-UCL PMID:24792364 NCBI chrNW_004955413:6,692,343...6,705,760
Ensembl chrNW_004955413:6,686,398...6,703,173 		JBrowse link
negative regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955547:2,278,548...2,293,865
Ensembl chrNW_004955547:2,279,042...2,294,443 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:20830586 RGD:9686141 NCBI chrNW_004955422:29,337,969...29,339,178
Ensembl chrNW_004955422:29,337,757...29,339,178 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in ISO (MGI:5661129|PMID:25535084) BHF-UCL PMID:25535084 MGI:5661129 NCBI chrNW_004955415:20,490,414...20,526,068
Ensembl chrNW_004955415:20,490,414...20,527,917 		JBrowse link
G Notch4 notch receptor 4 involved_in ISO (MGI:1934537|PMID:11344305) UniProt PMID:11344305 MGI:1934537 NCBI chrNW_004955437:658,076...679,338 JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO RGD PMID:17450384 RGD:2302022 NCBI chrNW_004955419:26,490,899...26,546,349
Ensembl chrNW_004955419:26,490,899...26,547,017 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO (PMID:25186293) MGI PMID:25186293 NCBI chrNW_004955561:1,573,525...1,578,295
Ensembl chrNW_004955561:1,573,525...1,580,511 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 involved_in ISO (PMID:23765923) BHF-UCL PMID:23765923 NCBI chrNW_004955429:23,011,627...23,198,188
Ensembl chrNW_004955429:23,010,790...23,198,250 		JBrowse link
negative regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in ISO (PMID:24851274) UniProt PMID:24851274 NCBI chrNW_004955515:3,024,258...3,035,996
Ensembl chrNW_004955515:3,024,258...3,035,996 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:20048167) ARUK-UCL PMID:20048167 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
Notch signaling pathway involved in arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (MGI:3847069|PMID:19144989) UniProt PMID:19144989 MGI:3847069 NCBI chrNW_004955411:3,478,943...3,486,541
Ensembl chrNW_004955411:3,478,033...3,486,604 		JBrowse link
positive regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955547:2,278,548...2,293,865
Ensembl chrNW_004955547:2,279,042...2,294,443 		JBrowse link
G Atoh8 atonal bHLH transcription factor 8 involved_in ISO (PMID:24463812) UniProt PMID:24463812 NCBI chrNW_004955424:1,775,139...1,803,106
Ensembl chrNW_004955424:1,776,127...1,802,763 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 involved_in ISO (PMID:15033446) UniProt PMID:15033446 NCBI chrNW_004955405:29,206,889...29,209,407
Ensembl chrNW_004955405:29,206,889...29,209,407 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO (PMID:18231602) MGI PMID:18231602 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Etv2 ETS variant transcription factor 2 acts_upstream_of_or_within ISO (PMID:18462699) MGI PMID:18462699 NCBI chrNW_004955468:4,857,023...4,859,926
Ensembl chrNW_004955468:4,857,595...4,860,531 		JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955556:2,204,841...2,210,335
Ensembl chrNW_004955556:2,205,071...2,209,055 		JBrowse link
G Notch1 notch receptor 1 ISO RGD PMID:19109527 RGD:2325303 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Tmem100 transmembrane protein 100 involved_in ISO (MGI:5432418|PMID:22783020) UniProt PMID:22783020 MGI:5432418 NCBI chrNW_004955451:6,982,094...6,988,345
Ensembl chrNW_004955451:6,985,277...6,988,345 		JBrowse link
G Vezf1 vascular endothelial zinc finger 1 involved_in ISO (PMID:27538588) BHF-UCL PMID:27538588 NCBI chrNW_004955451:5,014,310...5,031,080
Ensembl chrNW_004955451:5,014,218...5,032,225 		JBrowse link
positive regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 involved_in ISO (PMID:25978380)
(MGI:5796260|PMID:25978380)		 CAFA PMID:25978380 MGI:5796260 NCBI chrNW_004955514:1,784,302...1,812,845
Ensembl chrNW_004955514:1,783,814...1,815,917 		JBrowse link
G Akap11 A-kinase anchoring protein 11 ISO RGD PMID:25188285 RGD:14348953 NCBI chrNW_004955518:4,032,738...4,083,720
Ensembl chrNW_004955518:4,032,448...4,083,697 		JBrowse link
G Cdh5 cadherin 5 involved_in ISO (PMID:23288152) UniProt PMID:23288152 NCBI chrNW_004955433:22,957,718...22,994,515
Ensembl chrNW_004955433:22,967,960...22,992,924 		JBrowse link
G Cldn5 claudin 5 involved_in ISO (PMID:23288152) UniProt PMID:23288152 NCBI chrNW_004955442:18,509,501...18,511,267
Ensembl chrNW_004955442:18,509,676...18,510,332 		JBrowse link
G Dicer1 dicer 1, ribonuclease III ISO RGD PMID:23239824 RGD:149735901 NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G F11r F11 receptor involved_in ISO (PMID:26985018) ARUK-UCL PMID:26985018 NCBI chrNW_004955468:12,764,968...12,785,956
Ensembl chrNW_004955468:12,765,874...12,785,929 		JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:24280217) AgBase PMID:24280217 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa involved_in ISO (PMID:25651845) UniProt PMID:25651845 NCBI chrNW_004955459:3,097,229...3,105,566
Ensembl chrNW_004955459:3,094,120...3,104,135 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO (PMID:24851274) UniProt PMID:24851274 NCBI chrNW_004955495:1,528,963...1,530,527
Ensembl chrNW_004955495:1,529,428...1,530,486 		JBrowse link
regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apold1 apolipoprotein L domain containing 1 ISO RGD PMID:15102925 RGD:1303988 NCBI chrNW_004955413:9,682,032...9,685,965
Ensembl chrNW_004955413:9,681,955...9,687,910 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO (MGI:3640069|PMID:16680193) UniProt PMID:16680193 MGI:3640069 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO (PMID:18772315) MGI PMID:18772315 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO (MGI:5904576|PMID:27653213) UniProt PMID:27653213 MGI:5904576 NCBI chrNW_004955415:18,210,608...18,915,099
Ensembl chrNW_004955415:18,210,662...18,915,158 		JBrowse link
G Ppp1r12a protein phosphatase 1 regulatory subunit 12A NOT|involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955405:18,594,191...18,727,345
Ensembl chrNW_004955405:18,596,541...18,727,345 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021 		JBrowse link
G Vcl vinculin involved_in ISO (PMID:26923917) ARUK-UCL PMID:26923917 NCBI chrNW_004955437:17,812,998...17,920,253
Ensembl chrNW_004955437:17,813,007...17,920,253 		JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (MGI:5904576|PMID:27653213) UniProt PMID:27653213 MGI:5904576 NCBI chrNW_004955434:17,653,708...17,712,565
Ensembl chrNW_004955434:17,661,364...17,713,159 		JBrowse link
venous endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    cellular process 11480
      cellular developmental process 3877
        cell differentiation 3876
          epithelial cell differentiation 693
            endothelial cell differentiation 120
              blood vessel endothelial cell differentiation + 12
              cardiac endothelial cell differentiation + 6
              endothelial cell development + 75
              endothelial cell fate commitment + 8
              lymphatic endothelial cell differentiation + 8
              negative regulation of endothelial cell differentiation + 10
              positive regulation of endothelial cell differentiation + 11
              regulation of endothelial cell differentiation + 42
Path 2
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        tissue development 1975
          epithelium development 1234
            endothelium development 141
              endothelial cell differentiation 120
                blood vessel endothelial cell differentiation + 12
                cardiac endothelial cell differentiation + 6
                endothelial cell development + 75
                endothelial cell fate commitment + 8
                lymphatic endothelial cell differentiation + 8
                negative regulation of endothelial cell differentiation + 10
                positive regulation of endothelial cell differentiation + 11
                regulation of endothelial cell differentiation + 42
paths to the root