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ONTOLOGY REPORT - ANNOTATIONS


Term:endothelial cell differentiation
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Accession:GO:0045446 term browser browse the term
Definition:The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.



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endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 IMP RGD PMID:24955809 RGD:11352686 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Fstl1 follistatin-like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4457221|PMID:20054002)
UniProt
RGD
PMID:20054002 GO_REF:0000024 MGI:4457221 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
JBrowse link
G Hoxb5 homeo box B5 acts_upstream_of_or_within ISO (MGI:2670246|PMID:12897140) RGD PMID:12897140 MGI:2670246 NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
JBrowse link
G Kdm6b lysine demethylase 6B involved_in ISO (MGI:5574281|PMID:23856522) RGD PMID:23856522 MGI:5574281 NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kdr kinase insert domain receptor involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(MGI:2670246|PMID:12897140), (MGI:5543371|PMID:18772315)
Ensembl
RGD
PMID:12897140 PMID:18772315 PMID:21873635 GO_REF:0000107 MGI:2670246 MGI:5543371, RGD:13792537 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Notch4 notch receptor 4 IDA RGD PMID:10964583 RGD:1304484 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO MGI:2386336 (MGI:2177970|PMID:11927535) RGD PMID:11927535 MGI:2177970 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Ptn pleiotrophin IEP RGD PMID:20830586 RGD:9686141 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IEP RGD PMID:7959012 RGD:61573 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
arterial endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO UniProtKB:Q9QUS4 (MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:3040159 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO UniProtKB:Q9WV93 (MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:3040159 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:3040159 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO MGI:5432904|MGI:5432905 (MGI:5432418|PMID:22783020) RGD PMID:22783020 MGI:5432418 NCBI chr10:74,854,779...74,861,147
Ensembl chr10:74,854,468...74,862,941
JBrowse link
arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) RGD PMID:15466160 MGI:3056004 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO MGI:3512761 (MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:3837878 NCBI chr14:81,418,418...81,464,114
Ensembl chr14:81,418,236...81,464,116
JBrowse link
blood vessel endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO UniProtKB:P52800 (MGI:3056004|PMID:15466160) RGD PMID:15466160 MGI:3056004 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
endocardial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:4837019 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nrg1 neuregulin 1 involved_in ISO
IEA
(PMID:17336907)
GO_REF:0000107
RGD
Ensembl
PMID:17336907 GO_REF:0000107 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:4946551|PMID:21330551)
Ensembl
RGD
PMID:21330551 GO_REF:0000107 MGI:4946551 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO MGI:103559 (MGI:3716256|PMID:17610846) RGD PMID:17610846 MGI:3716256 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO MGI:107543 (MGI:3716256|PMID:17610846) RGD PMID:17610846 MGI:3716256 NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO
IEA
(PMID:19506109)
GO_REF:0000107
RGD
Ensembl
PMID:19506109 GO_REF:0000107 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
endothelial cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO MGI:1924696|MGI:3512761 (MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:3837878 NCBI chr14:81,418,418...81,464,114
Ensembl chr14:81,418,236...81,464,116
JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2158814 (MGI:3698597|PMID:16373599)
Ensembl
RGD
PMID:16373599 GO_REF:0000107 MGI:3698597 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 acts_upstream_of_or_within ISO MGI:2384924 (MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:3837878 NCBI chr11:67,006,954...67,095,020
Ensembl chr11:66,957,190...67,095,051
JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:158,856,582...158,880,490
Ensembl chr 5:158,868,672...158,880,271
JBrowse link
G Vezf1 vascular endothelial zinc finger 1 acts_upstream_of_or_within ISO MGI:3583268 (MGI:3581991|PMID:15882861) RGD PMID:15882861 MGI:3581991 NCBI chr10:72,859,669...72,876,111
Ensembl chr10:72,859,877...72,876,111
JBrowse link
endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa13 homeo box A13 acts_upstream_of_or_within ISO MGI:2152356 (MGI:3797428|PMID:18483557) RGD PMID:18483557 MGI:3797428 NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091
JBrowse link
endothelial cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 acts_upstream_of_or_within ISO MGI:5500046 (MGI:5486234|PMID:23372835) RGD PMID:23372835 MGI:5486234 NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Clic4 chloride intracellular channel 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3838012 (MGI:3837628|PMID:19197003)
Ensembl
RGD
PMID:19197003 GO_REF:0000107 MGI:3837628 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Cnmd chondromodulin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2656472|PMID:12714610)
RGD PMID:12714610 PMID:21873635 MGI:2656472, RGD:13792537 NCBI chr15:55,041,548...55,066,297
Ensembl chr15:55,041,561...55,066,297
JBrowse link
G Col15a1 collagen type XV alpha 1 chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3046127|PMID:15188432)
RGD PMID:15188432 PMID:21873635 MGI:3046127, RGD:13792537 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Col22a1 collagen type XXII alpha 1 chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:103,730,939...103,968,452
Ensembl chr 7:103,731,037...103,968,462
JBrowse link
G Col24a1 collagen type XXIV alpha 1 chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:234,212,256...234,469,445
Ensembl chr 2:234,212,324...234,469,441
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 acts_upstream_of_or_within ISO MGI:3838392 (MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:3837878 NCBI chr11:67,006,954...67,095,020
Ensembl chr11:66,957,190...67,095,051
JBrowse link
G Hoxa13 homeo box A13 acts_upstream_of_or_within ISO MGI:2152356 (MGI:3797428|PMID:18483557) RGD PMID:18483557 MGI:3797428 NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein acts_upstream_of_or_within ISO MGI:2679939 (MGI:3759000|PMID:17717145) RGD PMID:17717145 MGI:3759000 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO MGI:2157527 (MGI:4940123|PMID:21285373) RGD PMID:21285373 MGI:4940123 NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO
IEA
(PMID:14500721)
GO_REF:0000107
RGD
Ensembl
PMID:14500721 GO_REF:0000107 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Notch4 notch receptor 4 IDA RGD PMID:10964583 RGD:1304484 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:2677448 (MGI:3723364|PMID:17563397) RGD PMID:17563397 MGI:3723364 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 acts_upstream_of_or_within ISO MGI:3620600|MGI:3620601 (MGI:3618677|PMID:16467571) RGD PMID:16467571 MGI:3618677 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960
JBrowse link
G Stc1 stanniocalcin 1 involved_in ISO (PMID:14500721) RGD PMID:14500721 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Tnmd tenomodulin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2656472|PMID:12714610)
RGD PMID:12714610 PMID:21873635 MGI:2656472, RGD:13792537 NCBI chr  X:97,057,137...97,072,634
Ensembl chr  X:97,057,137...97,072,634
JBrowse link
endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5466218|PMID:22282195)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22282195 GO_REF:0000024 GO_REF:0000107 MGI:5466218 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
establishment of blood-nerve barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO MGI:2136636 (MGI:2385816|PMID:9734405) RGD PMID:9734405 MGI:2385816 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cldn1 claudin 1 IMP RGD PMID:22733753 RGD:11341802 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Dmd dystrophin acts_upstream_of_or_within ISO MGI:1856328 (MGI:3612931|PMID:12673830) RGD PMID:12673830 MGI:3612931 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4437572 (MGI:4437139|PMID:20181608)
Ensembl
RGD
PMID:20181608 GO_REF:0000107 MGI:4437139 NCBI chr 2:173,488,909...173,496,824
Ensembl chr 2:173,491,160...173,496,588
JBrowse link
G Ren renin NOT|acts_upstream_of_or_within ISO MGI:2136642 (MGI:1351364|PMID:10617578) RGD PMID:10617578 MGI:1351364 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn5 claudin 5 involved_in ISO (PMID:24280217) RGD PMID:24280217 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Ednra endothelin receptor type A involved_in ISO (MGI:6437578|PMID:27026367) RGD PMID:27026367 MGI:6437578 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (MGI:6437578|PMID:27026367) RGD PMID:27026367 MGI:6437578 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Ezr ezrin involved_in ISO UniProtKB:P26038|UniProtKB:P35241 (PMID:23264465) RGD PMID:23264465 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:20826780) RGD PMID:20826780 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Hpse heparanase involved_in ISO (MGI:6437578|PMID:27026367) RGD PMID:27026367 MGI:6437578 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO UniProtKB:Q96S97 (PMID:23264465) RGD PMID:23264465 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Marveld2 MARVEL domain containing 2 involved_in ISO (PMID:23073616) RGD PMID:23073616 NCBI chr 2:31,742,652...31,764,150 JBrowse link
G Msn moesin involved_in ISO
IEA
UniProtKB:P15311|UniProtKB:P35241 (PMID:23264465)
GO_REF:0000107
RGD
Ensembl
PMID:23264465 GO_REF:0000107 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Myadm myeloid-associated differentiation marker involved_in ISO
IEA
(PMID:23264465)
GO_REF:0000107
RGD
Ensembl
PMID:23264465 GO_REF:0000107 NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
JBrowse link
G Pde2a phosphodiesterase 2A involved_in IDA PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pde4d phosphodiesterase 4D involved_in IDA PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 involved_in ISO (PMID:7589563) RGD PMID:7589563 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18586956)
(MGI:5604907|PMID:21907835)
PMID:21873635
RGD PMID:18586956 PMID:21907835 PMID:21873635 MGI:5604907, RGD:13792537 NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in ISO
ISS
(PMID:21840392)
GO_REF:0000024
RGD
UniProt
PMID:21840392 GO_REF:0000024 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in ISO
ISS
(PMID:21840392)
GO_REF:0000024
RGD
UniProt
PMID:21840392 GO_REF:0000024 NCBI chr 7:53,423,039...53,456,388
Ensembl chr 7:53,423,130...53,456,370
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:21840392) RGD PMID:21840392 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:21840392)
UniProt
RGD
PMID:21840392 GO_REF:0000024 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 involved_in ISO
IEA
ISS
(PMID:21840392)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21840392 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
JBrowse link
G Rdx radixin involved_in ISO UniProtKB:P15311|UniProtKB:P26038 (PMID:23264465) RGD PMID:23264465 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Robo4 roundabout guidance receptor 4 involved_in ISO (PMID:30455415) RGD PMID:30455415 NCBI chr 8:37,119,966...37,133,887 JBrowse link
G Sox18 SRY-box transcription factor 18 involved_in ISO (PMID:18065521) RGD PMID:18065521 NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IMP RGD PMID:16850390 RGD:1598561 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Cldn3 claudin 3 involved_in ISO (MGI:6368952|PMID:12734665) RGD PMID:12734665 MGI:6368952 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Foxp3 forkhead box P3 IEP RGD PMID:31027862 RGD:38549575 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
establishment of endothelial intestinal barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afdn afadin, adherens junction formation factor involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 1:53,884,711...54,034,216
Ensembl chr 1:53,905,373...54,034,216
JBrowse link
G Cldn1 claudin 1 IMP RGD PMID:22684624 RGD:11341733 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G F11r F11 receptor involved_in ISO
IBA
UniProtKB:Q9Y3L5 (PMID:23885123)
PMID:21873635
RGD PMID:23885123 PMID:21873635 RGD:13792537 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fasn fatty acid synthase acts_upstream_of_or_within ISO MGI:3765070 (MGI:5630041|PMID:25565205) RGD PMID:25565205 MGI:5630041 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Icam1 intercellular adhesion molecule 1 IMP RGD PMID:10201790 RGD:11520782 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Mir874 microRNA 874 acts_upstream_of_or_within ISO (MGI:5551666|PMID:24462679) RGD PMID:24462679 MGI:5551666 NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:2385681 (MGI:5306517|PMID:22155109) RGD PMID:22155109 MGI:5306517 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2158734 (MGI:5550154|PMID:24385580)
Ensembl
RGD
PMID:24385580 GO_REF:0000107 MGI:5550154 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947
JBrowse link
G Rab1a RAB1A, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248
JBrowse link
G Rab1b RAB1B, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family NOT|involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
JBrowse link
G Rap2c RAP2C, member of RAS oncogene family involved_in ISO UniProtKB:Q9Y624 (PMID:23885123) RGD PMID:23885123 NCBI chr  X:130,504,554...130,517,671
Ensembl chr  X:130,504,698...130,518,328
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Rapgef6 Rap guanine nucleotide exchange factor 6 NOT|involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr10:38,655,854...38,824,227
Ensembl chr10:38,655,867...38,823,211
JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO
IBA
(PMID:23885123)
PMID:21873635
RGD PMID:23885123 PMID:21873635 RGD:13792537 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tjp2 tight junction protein 2 involved_in IBA
ISO
PMID:21873635
(PMID:23885123)
RGD PMID:23885123 PMID:21873635 RGD:13792537 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tjp3 tight junction protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279
JBrowse link
lymphatic endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B involved_in IEA
ISO
GO_REF:0000107
(MGI:4436974|PMID:19903896)
Ensembl
RGD
PMID:19903896 GO_REF:0000107 MGI:4436974 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:19903896)
(MGI:4436974|PMID:19903896)
RGD PMID:19903896 MGI:4436974 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:4436974|PMID:19903896) RGD PMID:19903896 MGI:4436974 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Prox1 prospero homeobox 1 involved_in
acts_upstream_of_or_within
ISO (PMID:12198161)
MGI:2182767|MGI:3609548 (MGI:3820329|PMID:19056883)
RGD PMID:12198161 PMID:19056883 MGI:3820329 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO MGI:2178809 (MGI:3828192|PMID:18931657) RGD PMID:18931657 MGI:3828192 NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 acts_upstream_of_or_within ISO (MGI:4439415|PMID:20223757) RGD PMID:20223757 MGI:4439415 NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592
JBrowse link
lymphatic endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 involved_in ISO (PMID:18815287) RGD PMID:18815287 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
JBrowse link
G Pdpn podoplanin involved_in ISS
ISO
GO_REF:0000024
(MGI:4453945|PMID:20110424)
UniProt
RGD
PMID:20110424 GO_REF:0000024 MGI:4453945 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:18815287) RGD PMID:18815287 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj2 forkhead box J2 involved_in ISO (PMID:24792364) RGD PMID:24792364 NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518
JBrowse link
negative regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IMP RGD PMID:20830586 RGD:9686141 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5661129|PMID:25535084)
Ensembl
RGD
PMID:25535084 GO_REF:0000107 MGI:5661129 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Notch4 notch receptor 4 involved_in ISO (MGI:1934537|PMID:11344305) RGD PMID:11344305 MGI:1934537 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP RGD PMID:17450384 RGD:2302022 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA
ISO
GO_REF:0000107
(PMID:18386220)
Ensembl
RGD
PMID:18386220 GO_REF:0000107 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 involved_in ISO (PMID:23765923) RGD PMID:23765923 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
negative regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in ISO (PMID:24851274) RGD PMID:24851274 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:20048167) RGD PMID:20048167 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Notch signaling pathway involved in arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3847069|PMID:19144989)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:19144989 GO_REF:0000024 GO_REF:0000107 MGI:3847069 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
positive regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 involved_in ISO (PMID:24463812) RGD PMID:24463812 NCBI chr 4:104,259,992...104,292,168
Ensembl chr 4:104,259,992...104,292,168
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:4830635|PMID:20406889)
Ensembl
RGD
PMID:20406889 GO_REF:0000107 MGI:4830635 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Btg1 BTG anti-proliferation factor 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:15033446)
UniProt
RGD
PMID:15033446 GO_REF:0000024 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2148567 (MGI:3773938|PMID:18231602)
Ensembl
RGD
PMID:18231602 GO_REF:0000107 MGI:3773938 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Etv2 ETS variant transcription factor 2 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) RGD PMID:18462699 MGI:4415813 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,255,430...9,261,429
JBrowse link
G Notch1 notch receptor 1 IMP RGD PMID:19109527 RGD:2325303 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Tmem100 transmembrane protein 100 involved_in ISO (MGI:5432418|PMID:22783020) RGD PMID:22783020 MGI:5432418 NCBI chr10:74,854,779...74,861,147
Ensembl chr10:74,854,468...74,862,941
JBrowse link
G Vezf1 vascular endothelial zinc finger 1 involved_in ISO (PMID:27538588) RGD PMID:27538588 NCBI chr10:72,859,669...72,876,111
Ensembl chr10:72,859,877...72,876,111
JBrowse link
positive regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 involved_in ISO
IEA
IBA
(PMID:25978380)
(MGI:5796260|PMID:25978380)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:25978380 PMID:21873635 GO_REF:0000107 MGI:5796260, RGD:13792537 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Akap11 A-kinase anchoring protein 11 IMP RGD PMID:25188285 RGD:14348953 NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605
JBrowse link
G Cdh5 cadherin 5 involved_in ISO (PMID:23288152) RGD PMID:23288152 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cldn5 claudin 5 involved_in ISO (PMID:23288152) RGD PMID:23288152 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Dicer1 dicer 1 ribonuclease III IMP RGD PMID:23239824 RGD:149735901 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G F11r F11 receptor involved_in ISO (PMID:26985018) RGD PMID:26985018 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:24280217) RGD PMID:24280217 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa involved_in ISO
IEA
ISS
(PMID:25651845)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:25651845 GO_REF:0000024 GO_REF:0000107 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO (PMID:24851274) RGD PMID:24851274 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apold1 apolipoprotein L domain containing 1 involved_in IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:15102925 PMID:21873635 RGD:1303988, RGD:13792537 NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:4830635 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3640069|PMID:16680193)
UniProt
RGD
PMID:16680193 GO_REF:0000024 MGI:3640069 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Tgfb3 transforming growth factor, beta 3 TAS RGD PMID:12183510 RGD:727411 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO (MGI:5543371|PMID:18772315) RGD PMID:18772315 MGI:5543371 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in ISO
IEA
(PMID:25816133)
GO_REF:0000107
RGD
Ensembl
PMID:25816133 GO_REF:0000107 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5904576|PMID:27653213)
Ensembl
RGD
PMID:27653213 GO_REF:0000107 MGI:5904576 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A NOT|involved_in ISO (PMID:25816133) RGD PMID:25816133 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
UniProtKB:O75116 (PMID:25816133)
GO_REF:0000107
RGD
Ensembl
PMID:25816133 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q13464 (PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:25816133) RGD PMID:25816133 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Vcl vinculin involved_in IEA
ISO
GO_REF:0000107
(PMID:26923917)
Ensembl
RGD
PMID:26923917 GO_REF:0000107 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (MGI:5904576|PMID:27653213) RGD PMID:27653213 MGI:5904576 NCBI chr 5:97,227,621...97,286,866
Ensembl chr 5:97,229,345...97,286,537
JBrowse link
venous endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:4837019 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular developmental process 4543
        cell differentiation 4448
          epithelial cell differentiation 725
            endothelial cell differentiation 125
              blood vessel endothelial cell differentiation + 8
              cardiac endothelial cell differentiation + 6
              endothelial cell development + 83
              endothelial cell fate commitment + 7
              lymphatic endothelial cell differentiation + 8
              negative regulation of endothelial cell differentiation + 11
              positive regulation of endothelial cell differentiation + 11
              regulation of endothelial cell differentiation + 44
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        tissue development 2109
          epithelium development 1297
            endothelium development 146
              endothelial cell differentiation 125
                blood vessel endothelial cell differentiation + 8
                cardiac endothelial cell differentiation + 6
                endothelial cell development + 83
                endothelial cell fate commitment + 7
                lymphatic endothelial cell differentiation + 8
                negative regulation of endothelial cell differentiation + 11
                positive regulation of endothelial cell differentiation + 11
                regulation of endothelial cell differentiation + 44
paths to the root