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ONTOLOGY REPORT - ANNOTATIONS

Term:MHC class II biosynthetic process
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Accession:GO:0045342 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.
Synonyms:exact_synonym: MHC class II anabolism;   MHC class II biosynthesis;   MHC class II formation;   MHC class II synthesis;   major histocompatibility complex class II biosynthesis;   major histocompatibility complex class II biosynthetic process


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MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857755 (PMID:8301134) 		Ensembl
RGD		 PMID:8301134 GO_REF:0000107 NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:83,406,427...83,417,238 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
negative regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 involved_in ISO
IEA 		(PMID:1940799)
GO_REF:0000107 		RGD
Ensembl		 PMID:1940799 GO_REF:0000107 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Marchf8 membrane associated ring-CH-type finger 8 involved_in ISO (PMID:16785530) RGD PMID:16785530 NCBI chr 4:151,086,076...151,203,205
Ensembl chr 4:151,088,506...151,203,205 		JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 acts_upstream_of_or_within ISO (PMID:12047746) RGD PMID:12047746 NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889 		JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392 		JBrowse link
G Slc25a2 solute carrier family 25 member 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:29,704,182...29,707,563
Ensembl chr18:29,703,871...29,708,827 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in IEA
ISO 		GO_REF:0000107
(PMID:7592651) 		Ensembl
RGD		 PMID:7592651 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:20937824) RGD PMID:20937824 NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712 		JBrowse link
positive regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40lg CD40 ligand IDA RGD PMID:18262271 RGD:2313421 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in ISO (PMID:29020624) RGD PMID:29020624 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator involved_in IEP
IDA
ISO
IBA 		(PMID:19041327)
GO_REF:0000033 		RGD
GO_Central		 PMID:19041327 PMID:11477547 PMID:11071855 GO_REF:0000033, RGD:632487, RGD:632488 NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,647,085...5,694,342 		JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within 		IEP
IEA
ISO 		GO_REF:0000117
UniProtKB:P05067|UniProtKB:P49768 (PMID:1845803), (PMID:2493384), (PMID:2502420), (PMID:26227742)
(PMID:11027433) 		UniProt
RGD		 PMID:1845803 PMID:2493384 PMID:2502420 PMID:11027433 PMID:26227742 More... GO_REF:0000117, RGD:8547557 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11027433) 		Ensembl
RGD		 PMID:11027433 GO_REF:0000107 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il33 interleukin 33 acts_upstream_of_or_within ISO (PMID:26936882) RGD PMID:26936882 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:10549626), (PMID:11027433) RGD PMID:10549626 PMID:11027433 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Jak2 Janus kinase 2 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P01580 (PMID:26227742) 		Ensembl
RGD		 PMID:26227742 GO_REF:0000107 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Rfx5 regulatory factor X5 involved_in ISO (PMID:19041327) RGD PMID:19041327 NCBI chr 2:185,210,206...185,217,735
Ensembl chr 2:185,210,217...185,217,743 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA 		(PMID:21890893)
GO_REF:0000107 		RGD
Ensembl		 PMID:21890893 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1860885 (PMID:10549626) 		Ensembl
RGD		 PMID:10549626 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmem106a transmembrane protein 106A involved_in ISS
ISO 		GO_REF:0000024
(PMID:26215746) 		UniProt
RGD		 PMID:26215746 GO_REF:0000024 NCBI chr10:87,007,144...87,016,161
Ensembl chr10:87,007,165...87,016,157 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:1903538)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:1903538 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        macromolecule metabolic process 9453
          macromolecule biosynthetic process 7273
            MHC class II biosynthetic process 20
              negative regulation of MHC class II biosynthetic process 7
              positive regulation of MHC class II biosynthetic process 13
              regulation of MHC class II biosynthetic process + 19
paths to the root