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ONTOLOGY REPORT - ANNOTATIONS

Term:MHC class II biosynthetic process
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Accession:GO:0045342 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.
Synonyms:exact_synonym: MHC class II anabolism;   MHC class II biosynthesis;   MHC class II formation;   MHC class II synthesis;   major histocompatibility complex class II biosynthesis;   major histocompatibility complex class II biosynthetic process


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MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of ISO (MGI:2178646|PMID:10549626) RGD PMID:10549626 MGI:2178646 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within ISO MGI:1857755 (MGI:64652|PMID:8301134) RGD PMID:8301134 MGI:64652 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of
involved_in		 ISO
IEA		 MGI:1860885 (MGI:2178646|PMID:10549626)
GO_REF:0000107		 RGD
Ensembl		 PMID:10549626 GO_REF:0000107 MGI:2178646 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
negative regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 involved_in ISO (PMID:1940799) RGD PMID:1940799 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Marchf8 membrane associated ring-CH-type finger 8 involved_in ISO (MGI:3785681|PMID:16785530) RGD PMID:16785530 MGI:3785681 NCBI chr 4:149,415,642...149,530,771
Ensembl chr 4:149,416,071...149,530,770 		JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 acts_upstream_of_or_within ISO (MGI:2180954|PMID:12047746) RGD PMID:12047746 MGI:2180954 NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912 		JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:4942273|PMID:7592651) RGD PMID:7592651 MGI:4942273 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:20937824) RGD PMID:20937824 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134 		JBrowse link
positive regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40lg CD40 ligand IDA RGD PMID:18262271 RGD:2313421 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in ISO (PMID:29020624) RGD PMID:29020624 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator involved_in IEP
IBA
IDA		 PMID:21873635 RGD
GO_Central		 PMID:11477547 PMID:21873635 PMID:11071855 RGD:632487, RGD:13792537, RGD:632488 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440 		JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within		 IEP
ISO		 UniProtKB:P05067|UniProtKB:P49768 (MGI:4942276|PMID:2502420), (MGI:4942277|PMID:2493384), (MGI:4943415|PMID:1845803), (MGI:5776417|PMID:26227742)
(MGI:3033882|PMID:11027433)		 RGD PMID:1845803 PMID:2493384 PMID:2502420 PMID:11027433 PMID:26227742 More... MGI:3033882 MGI:4942276 MGI:4942277 MGI:4943415 MGI:5776417, RGD:8547557 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within ISO (MGI:3033882|PMID:11027433) RGD PMID:11027433 MGI:3033882 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:6414704|PMID:26936882)		 Ensembl
RGD		 PMID:26936882 GO_REF:0000107 MGI:6414704 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2178646|PMID:10549626), (MGI:3033882|PMID:11027433)		 RGD PMID:10549626 PMID:11027433 PMID:21873635 MGI:2178646 MGI:3033882, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO UniProtKB:P01580 (MGI:5776417|PMID:26227742) RGD PMID:26227742 MGI:5776417 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:21890893) RGD PMID:21890893 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1860885 (MGI:2178646|PMID:10549626)		 Ensembl
RGD		 PMID:10549626 GO_REF:0000107 MGI:2178646 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem106a transmembrane protein 106A involved_in ISS
ISO		 GO_REF:0000024
(MGI:6216178|PMID:26215746)		 UniProt
RGD		 PMID:26215746 GO_REF:0000024 MGI:6216178 NCBI chr10:86,506,908...86,515,915
Ensembl chr10:86,506,936...86,515,892 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:1903538)		 UniProt
Ensembl
RGD		 PMID:1903538 GO_REF:0000024 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      organic substance metabolic process 11557
        macromolecule metabolic process 9294
          macromolecule biosynthetic process 5139
            MHC class II biosynthetic process 18
              negative regulation of MHC class II biosynthetic process 6
              positive regulation of MHC class II biosynthetic process 12
              regulation of MHC class II biosynthetic process + 17
paths to the root