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ONTOLOGY REPORT - ANNOTATIONS


Term:fumarate reductase complex
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Accession:GO:0045283 term browser browse the term
Definition:A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
Comment:See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.



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mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sdha succinate dehydrogenase complex flavoprotein subunit A part_of
located_in
ISS
ISO
IBA
IC
GO_REF:0000024
(PMID:15989954), (PMID:17480203)
PMID:21873635
PMID:30030361
UniProt
RGD
PMID:15989954 PMID:17480203 PMID:21873635 PMID:30030361 GO_REF:0000024, RGD:13792537, RGD:151356635 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B part_of
located_in
ISO
ISS
IC
(PMID:15989954), (PMID:17480203)
GO_REF:0000024
(MGI:4412318|PMID:19837698)
PMID:30030361
RGD
UniProt
PMID:15989954 PMID:17480203 PMID:19837698 PMID:30030361 GO_REF:0000024 MGI:4412318, RGD:151356635 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C part_of
located_in
IBA
ISO
IC
PMID:21873635
(PMID:17480203)
PMID:30030361
RGD PMID:17480203 PMID:21873635 PMID:30030361 RGD:13792537, RGD:151356635 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D part_of
located_in
ISS
ISO
IBA
IC
GO_REF:0000024
(PMID:15989954)
PMID:21873635
PMID:30030361
UniProt
RGD
PMID:15989954 PMID:21873635 PMID:30030361 GO_REF:0000024, RGD:13792537, RGD:151356635 NCBI chr 8:50,944,717...50,954,298
Ensembl chr 8:50,944,704...50,954,238
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20621
    protein-containing complex 6394
      catalytic complex 1808
        fumarate reductase complex 4
          mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4
          plasma membrane fumarate reductase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20621
    cellular anatomical entity 20375
      membrane 10515
        respirasome 148
          respiratory chain complex 131
            respiratory chain complex II 4
              fumarate reductase complex 4
                mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4
                plasma membrane fumarate reductase complex 0
paths to the root