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ONTOLOGY REPORT - ANNOTATIONS

Term:fumarate reductase complex
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Accession:GO:0045283 term browser browse the term
Definition:A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
Comment:See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.


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mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sdha succinate dehydrogenase complex flavoprotein subunit A part_of
located_in		 ISS
ISO
IBA
NAS		 GO_REF:0000024
(PMID:15989954), (PMID:17480203)
PMID:21873635
PMID:30030361		 UniProt
RGD		 PMID:15989954 PMID:17480203 PMID:21873635 PMID:30030361 GO_REF:0000024, RGD:13792537, RGD:151356635 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B part_of
located_in		 ISO
ISS
NAS
IEA		 (PMID:15989954), (PMID:17480203)
GO_REF:0000024
(MGI:4412318|PMID:19837698)
PMID:30030361
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:15989954 PMID:17480203 PMID:19837698 PMID:30030361 GO_REF:0000024 GO_REF:0000107 MGI:4412318, RGD:151356635 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C part_of
located_in		 IBA
ISO
NAS		 PMID:21873635
(PMID:17480203)
PMID:30030361		 RGD PMID:17480203 PMID:21873635 PMID:30030361 RGD:13792537, RGD:151356635 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D part_of
located_in		 ISS
ISO
IBA
NAS		 GO_REF:0000024
(PMID:15989954)
PMID:21873635
PMID:30030361		 UniProt
RGD		 PMID:15989954 PMID:21873635 PMID:30030361 GO_REF:0000024, RGD:13792537, RGD:151356635 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20107
    protein-containing complex 6459
      catalytic complex 1835
        fumarate reductase complex 4
          mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4
          plasma membrane fumarate reductase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20107
    cellular anatomical entity 19950
      membrane 10152
        respirasome 145
          respiratory chain complex 129
            respiratory chain complex II 4
              fumarate reductase complex 4
                mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4
                plasma membrane fumarate reductase complex 0
paths to the root