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ONTOLOGY REPORT - ANNOTATIONS


Term:cytosolic pyruvate dehydrogenase complex
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Accession:GO:0045250 term browser browse the term
Definition:Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
Comment:Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
Synonyms:related_synonym: pyruvate dehydrogenase complex (lipoamide)


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Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19837
      cytosol 4245
        cytosolic pyruvate dehydrogenase complex 0
Path 2
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  cellular_component 20137
    cellular anatomical entity 19837
      intracellular anatomical structure 14407
        cytoplasm 11397
          cytosol 4245
            cytosolic pyruvate dehydrogenase complex 0
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