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ONTOLOGY REPORT - ANNOTATIONS

Term:sarcomere organization
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Accession:GO:0045214 term browser browse the term
Definition:The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Synonyms:exact_synonym: sarcomere alignment;   sarcomere organisation
 alt_id: GO:0006938

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sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTG1 actin gamma 1 acts_upstream_of_or_within ISO (PMID:15194427) MGI PMID:15194427 NCBI chr16:73,456,907...73,459,777 JBrowse link
G ACTN2 actinin alpha 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:73,827,900...73,904,516
Ensembl chr25:73,827,874...73,905,146 		JBrowse link
G BMP10 bone morphogenetic protein 10 involved_in ISO PMID:17921333 BHF-UCL PMID:17921333 RGD:2302083 NCBI chr14:38,253,093...38,260,027
Ensembl chr14:38,253,890...38,259,621 		JBrowse link
G CAPN3 calpain 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr26:40,568,320...40,657,443
Ensembl chr26:40,568,885...40,625,597 		JBrowse link
G CASQ1 calsequestrin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:3,744,921...3,759,220
Ensembl chr20:3,744,780...3,756,435 		JBrowse link
G CASQ2 calsequestrin 2 involved_in ISO (PMID:19920148) UniProt PMID:19920148 NCBI chr20:17,937,089...18,008,433
Ensembl chr20:17,937,524...18,008,786 		JBrowse link
G CFL2 cofilin 2 acts_upstream_of_or_within ISO (PMID:22343409) MGI PMID:22343409 NCBI chr24:11,541,226...11,545,690
Ensembl chr24:11,543,638...11,544,335 		JBrowse link
G CSRP1 cysteine and glycine rich protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:27,908,426...27,932,107
Ensembl chr25:27,908,554...27,933,275 		JBrowse link
G CSRP2 cysteine and glycine rich protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:72,435,817...72,455,954
Ensembl chr11:72,434,598...72,455,929 		JBrowse link
G CSRP3 cysteine and glycine rich protein 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:45,792,106...45,813,715
Ensembl chr 1:45,803,243...45,813,800 		JBrowse link
G FHOD3 formin homology 2 domain containing 3 acts_upstream_of_or_within
involved_in 		ISO
IEA 		PMID:19706596
(PMID:19706596) 		MGI
TreeGrafter		 PMID:19706596 GO_REF:0000118 RGD:8554207 NCBI chr18:44,053,360...44,540,820
Ensembl chr18:44,049,837...44,540,760 		JBrowse link
G FLII FLII actin remodeling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:17,285,400...17,300,210
Ensembl chr16:17,285,724...17,300,041 		JBrowse link
G FLNC filamin C involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:97,431,666...97,460,178
Ensembl chr21:97,431,648...97,461,135 		JBrowse link
G IGSF22 immunoglobulin superfamily member 22 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:46,201,214...46,222,115
Ensembl chr 1:46,201,855...46,225,533 		JBrowse link
G ITGB1 integrin subunit beta 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:32,201,030...32,258,247
Ensembl chr 9:32,202,204...32,258,154 		JBrowse link
G KRT19 keratin 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,714,497...64,719,805
Ensembl chr16:64,714,970...64,719,678 		JBrowse link
G KRT8 keratin 8 involved_in ISO PMID:15247274 UniProt PMID:15247274 RGD:1600063 NCBI chr11:49,027,879...49,051,753 JBrowse link
G LDB3 LIM domain binding 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:45,130,015...45,199,585
Ensembl chr 9:45,128,134...45,198,106 		JBrowse link
G LMOD2 leiomodin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:92,454,067...92,462,904
Ensembl chr21:92,454,438...92,462,958 		JBrowse link
G LOC103231478 myosin-6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr29:23,753,251...23,780,822
Ensembl chr29:23,753,309...23,778,107 		JBrowse link
G LOC103231480 myosin-7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr29:23,783,610...23,804,981
Ensembl chr29:23,783,557...23,799,771 		JBrowse link
G MYBPC1 myosin binding protein C1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:96,843,331...96,942,336
Ensembl chr11:96,843,512...96,944,035 		JBrowse link
G MYBPC2 myosin binding protein C2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:43,493,862...43,530,931
Ensembl chr 6:43,494,619...43,531,554 		JBrowse link
G MYBPC3 myosin binding protein C3 acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:16380103)
(PMID:16224063), (PMID:17075052) 		MGI
TreeGrafter		 PMID:16224063 PMID:16380103 PMID:17075052 GO_REF:0000118 NCBI chr 1:17,964,581...17,986,351
Ensembl chr 1:17,963,706...17,985,758 		JBrowse link
G MYH7 myosin heavy chain 7 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr29:23,783,557...23,799,771 JBrowse link
G MYLK3 myosin light chain kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,553,897...32,593,968
Ensembl chr 5:32,553,602...32,593,638 		JBrowse link
G MYOM1 myomesin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:62,321,086...62,474,955
Ensembl chr18:62,320,793...62,465,485 		JBrowse link
G MYOM2 myomesin 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:1,634,917...1,809,804
Ensembl chr 8:1,705,074...1,809,874 		JBrowse link
G MYOZ1 myozenin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:57,649,829...57,660,148
Ensembl chr 9:57,650,298...57,660,345 		JBrowse link
G MYOZ2 myozenin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:66,615,254...66,666,060
Ensembl chr 7:66,616,084...66,666,263 		JBrowse link
G MYPN myopalladin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:63,173,243...63,279,777
Ensembl chr 9:63,174,804...63,279,133 		JBrowse link
G NEURL2 neuralized E3 ubiquitin protein ligase 2 acts_upstream_of_or_within ISO (PMID:14960280) MGI PMID:14960280 NCBI chr 2:17,993,531...17,996,207
Ensembl chr 2:17,993,827...17,999,082 		JBrowse link
G PLEC plectin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,125,471...138,187,209
Ensembl chr 8:138,125,280...138,149,364 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:53,021,666...53,042,594
Ensembl chr16:53,023,963...53,042,493 		JBrowse link
G SIX4 SIX homeobox 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:37,899,463...37,911,875
Ensembl chr24:37,900,909...37,911,612 		JBrowse link
G SRF serum response factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:28,983,161...28,993,465
Ensembl chr17:28,983,002...28,992,995 		JBrowse link
G SYNPO2L synaptopodin 2 like involved_in ISO (PMID:29206857) BHF-UCL PMID:29206857 NCBI chr 9:57,629,836...57,650,458
Ensembl chr 9:57,631,111...57,646,400 		JBrowse link
G TCAP titin-cap involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,500,535...66,503,455
Ensembl chr16:66,500,949...66,501,703 		JBrowse link
G TNNT1 troponin T1, slow skeletal type involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:47,726,049...47,743,465
Ensembl chr 6:47,726,002...47,743,404 		JBrowse link
G TNNT2 troponin T2, cardiac type acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:10449439) MGI
TreeGrafter		 PMID:10449439 GO_REF:0000118 NCBI chr25:28,035,563...28,054,322
Ensembl chr25:28,040,087...28,054,120 		JBrowse link
G TNNT3 troponin T3, fast skeletal type involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:1,718,729...1,738,271
Ensembl chr 1:1,718,523...1,738,477 		JBrowse link
G TPM1 tropomyosin 1 involved_in ISO (PMID:11273725) BHF-UCL PMID:11273725 NCBI chr26:20,458,287...20,487,387
Ensembl chr26:20,466,037...20,487,135 		JBrowse link
G TTN titin involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:17360664)
(PMID:16702235) 		RGD
TreeGrafter
MGI		 PMID:11034912 PMID:16702235 PMID:17360664 GO_REF:0000118 RGD:634444 NCBI chr10:64,074,994...64,379,055
Ensembl chr10:64,076,021...64,347,205 		JBrowse link
G WDR1 WD repeat domain 1 involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr27:39,929,749...39,973,892
Ensembl chr27:39,929,787...39,974,012 		JBrowse link
G XIRP1 xin actin binding repeat containing 1 acts_upstream_of_or_within ISO (PMID:17766470) MGI PMID:17766470 NCBI chr15:221,365...232,284 JBrowse link
negative regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:44,726,597...44,740,456
Ensembl chr22:44,727,624...44,740,459 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:24777478 RGD:13204833 NCBI chr20:119,787,700...119,818,455
Ensembl chr20:119,787,370...119,816,693 		JBrowse link
positive regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP10 bone morphogenetic protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,253,093...38,260,027
Ensembl chr14:38,253,890...38,259,621 		JBrowse link
G EDN1 endothelin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:12724418 RGD:2312280 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G MYLK3 myosin light chain kinase 3 involved_in ISO PMID:17885681 BHF-UCL PMID:17885681 RGD:8554371 NCBI chr 5:32,553,897...32,593,968
Ensembl chr 5:32,553,602...32,593,638 		JBrowse link
G PRKD1 protein kinase D1 ISO RGD PMID:16648482 RGD:243065275
G PROX1 prospero homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:15,533,546...15,592,834
Ensembl chr25:15,538,964...15,587,059 		JBrowse link
regulation of sarcomere organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP13 A-kinase anchoring protein 13 involved_in ISO (PMID:20139090) UniProt PMID:20139090 NCBI chr29:4,009,921...4,364,226
Ensembl chr29:4,106,732...4,359,516 		JBrowse link
G ANKRD23 ankyrin repeat domain 23 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:1,164,356...1,170,437
Ensembl chr14:1,165,361...1,170,408 		JBrowse link
G HDAC2 histone deacetylase 2 acts_upstream_of_or_within ISO (PMID:17322895) MGI PMID:17322895 NCBI chr13:59,873,248...59,904,542
Ensembl chr13:59,873,767...59,905,742 		JBrowse link
G MEF2C myocyte enhancer factor 2C acts_upstream_of_or_within ISO (PMID:17875930) MGI PMID:17875930 NCBI chr 4:82,702,378...82,887,491
Ensembl chr 4:82,706,738...82,788,152 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19706
    developmental process 6945
      anatomical structure formation involved in morphogenesis 1327
        cellular component assembly involved in morphogenesis 154
          myofibril assembly 80
            sarcomere organization 55
              negative regulation of sarcomere organization 2
              positive regulation of sarcomere organization 6
              regulation of sarcomere organization + 12
Path 2
Term Annotations click to browse term
  biological_process 19706
    cellular process 19211
      cellular component organization or biogenesis 8786
        cellular component organization 8574
          organelle organization 3611
            cytoskeleton organization 1531
              actin cytoskeleton organization 730
                actomyosin structure organization 229
                  myofibril assembly 80
                    sarcomere organization 55
                      negative regulation of sarcomere organization 2
                      positive regulation of sarcomere organization 6
                      regulation of sarcomere organization + 12
paths to the root