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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of bone resorption
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Accession:GO:0045124 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).


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regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor NOT|acts_upstream_of_or_within ISO MGI:3038975 (PMID:14970190) RGD PMID:14970190 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Car2 carbonic anhydrase 2 TAS RGD PMID:9665810 RGD:1342423 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IMP PMID:17121910 UniProt PMID:17121910 RGD:2293713 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha acts_upstream_of_or_within ISO MGI:5302406 (PMID:21844205) RGD PMID:21844205 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
MGI:1857478 (PMID:17053831)
GO_REF:0000107		 HGNC-UCL
RGD
Ensembl		 PMID:17053831 GO_REF:0000024 GO_REF:0000107 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
IEA		 (MGI:5303050|PMID:21803180)
GO_REF:0000107		 RGD
Ensembl		 PMID:21803180 GO_REF:0000107 MGI:5303050 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3839226|PMID:19204730)		 UniProt
RGD		 PMID:19204730 GO_REF:0000024 MGI:3839226 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:22451653)		 GO_Central
RGD		 PMID:22451653 GO_REF:0000033 NCBI chr18:71,506,416...71,521,894
Ensembl chr18:71,505,399...71,521,881 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5469753|PMID:23341620)		 UniProt
RGD		 PMID:23341620 GO_REF:0000024 MGI:5469753 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10822112), (PMID:17241109) RGD PMID:10822112 PMID:17241109 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cartpt CART prepropeptide involved_in ISO (PMID:16614075)
UniProtKB:P56450 (MGI:3696590|PMID:16614075)		 RGD PMID:16614075 MGI:3696590 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Cd38 CD38 molecule IDA RGD PMID:10477767 RGD:2307268 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:5560663 (PMID:25490771) RGD PMID:25490771 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (PMID:22437732) RGD PMID:22437732 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:10411542 RGD:5134371 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IMP RGD PMID:8694895 RGD:7257714 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO MGI:2384087 (PMID:11089565), (PMID:17332067) RGD PMID:11089565 PMID:17332067 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082 		JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in ISO
IBA		 (MGI:6362357|PMID:31173907)
GO_REF:0000033		 RGD
GO_Central		 PMID:31173907 GO_REF:0000033 MGI:6362357 NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835 		JBrowse link
G Hamp hepcidin antimicrobial peptide acts_upstream_of_or_within ISO MGI:4351741 (PMID:24561287) RGD PMID:24561287 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Iapp islet amyloid polypeptide acts_upstream_of_or_within ISO MGI:2656235 (PMID:14970190) RGD PMID:14970190 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2386884 (PMID:12161749)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:12161749 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (PMID:12677010) RGD PMID:12677010 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr13:82,437,418...82,461,511
Ensembl chr13:82,437,428...82,461,509 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO (MGI:5543589|PMID:22416756) RGD PMID:22416756 MGI:5543589 NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B IMP
IDA		 RGD PMID:11839361 PMID:16912914 RGD:730196, RGD:1624170 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:23149425)		 GO_Central
RGD		 PMID:23149425 GO_REF:0000033 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201 		JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:15312247 RGD:1580559 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07002627.1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:76,911,602...76,914,024 JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (MGI:5009189|PMID:11341326), (MGI:5009349|PMID:20683884) RGD PMID:11341326 PMID:20683884 MGI:5009189 MGI:5009349 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein IMP RGD PMID:10500999 RGD:1625797 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Car2 carbonic anhydrase 2 IMP RGD PMID:8674544 RGD:1600722 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in ISO (MGI:3588832|PMID:16061724), (MGI:5426134|PMID:17164993), (MGI:5426135|PMID:16937266) RGD PMID:16061724 PMID:16937266 PMID:17164993 MGI:3588832 MGI:5426134 MGI:5426135 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Def8 differentially expressed in FDCP 8 homolog involved_in ISS
ISO		 GO_REF:0000024
(MGI:5806241|PMID:27777970)		 UniProt
RGD		 PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 acts_upstream_of_or_within ISO MGI:3526402 (PMID:21308776) RGD PMID:21308776 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:2981075 RGD:10395245 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (MGI:5641770|PMID:25824719) RGD PMID:25824719 MGI:5641770 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Fshb follicle stimulating hormone subunit beta acts_upstream_of_or_within ISO MGI:1857434 (PMID:16630814) RGD PMID:16630814 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (PMID:19834056) RGD PMID:19834056 NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522 		JBrowse link
G Itgb3 integrin subunit beta 3 IMP RGD PMID:8603604 RGD:5024929 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2673982 (PMID:18505367) RGD PMID:18505367 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (PMID:15878314) RGD PMID:15878314 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
G Mc4r melanocortin 4 receptor involved_in ISO (PMID:16614075)
(MGI:3696590|PMID:16614075)		 RGD PMID:16614075 MGI:3696590 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Oscar osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO (PMID:11805147) RGD PMID:11805147 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5806241|PMID:27777970)		 UniProt
RGD		 PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta involved_in ISO
IEA		 (MGI:3838421|PMID:19252502)
GO_REF:0000107		 RGD
Ensembl		 PMID:19252502 GO_REF:0000107 MGI:3838421 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Prkca protein kinase C, alpha involved_in ISO (MGI:5284791|PMID:16014375) RGD PMID:16014375 MGI:5284791 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11792579 RGD:729815 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Spp1 secreted phosphoprotein 1 involved_in IDA
IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central
RGD		 PMID:11792563 GO_REF:0000033 GO_REF:0000118, RGD:1581129 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IMP RGD PMID:8514886 RGD:150524326 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3703840|PMID:17353363)		 UniProt
Ensembl
RGD		 PMID:17353363 GO_REF:0000024 GO_REF:0000107 MGI:3703840 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tf transferrin involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tmem64 transmembrane protein 64 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3880885 (PMID:23395171)		 GO_Central
RGD		 PMID:23395171 GO_REF:0000033 NCBI chr 5:28,698,947...28,745,384
Ensembl chr 5:28,698,918...28,745,330 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:11805147)		 GO_Central
RGD		 PMID:11805147 GO_REF:0000033 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in IMP
ISO
IEA		 (PMID:17241109)
GO_REF:0000107		 RGD
Ensembl		 PMID:17241109 PMID:11092398 GO_REF:0000107, RGD:730134 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    multicellular organismal process 8921
      multicellular organismal-level homeostasis 945
        tissue homeostasis 287
          bone resorption 84
            regulation of bone resorption 56
              negative regulation of bone resorption 20
              positive regulation of bone resorption 28
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of multicellular organismal process 3373
          regulation of tissue remodeling 91
            regulation of bone remodeling 67
              regulation of bone resorption 56
                negative regulation of bone resorption 20
                positive regulation of bone resorption 28
paths to the root