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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin biosynthetic process
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Accession:GO:0045122 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin anabolism;   aflatoxin biosynthesis;   aflatoxin formation;   aflatoxin synthesis


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Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      secondary metabolic process 64
        toxin metabolic process 19
          mycotoxin metabolic process 4
            aflatoxin metabolic process 4
              aflatoxin biosynthetic process 0
                negative regulation of aflatoxin biosynthetic process 0
                positive regulation of aflatoxin biosynthetic process 0
                regulation of aflatoxin biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      small molecule metabolic process 1839
        organic acid metabolic process 1073
          oxoacid metabolic process 1046
            carboxylic acid metabolic process 998
              monocarboxylic acid metabolic process 656
                acetate metabolic process 2
                  aflatoxin biosynthetic process 0
                    negative regulation of aflatoxin biosynthetic process 0
                    positive regulation of aflatoxin biosynthetic process 0
                    regulation of aflatoxin biosynthetic process + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.