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ONTOLOGY REPORT - ANNOTATIONS

Term:intermediate filament polymerization
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Accession:GO:0045107 term browser browse the term
Definition:Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.


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intermediate filament polymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Krt5 keratin 5 involved_in IMP (MGI:2179054|PMID:11408584) UniProt PMID:11408584 MGI:2179054 NCBI chr15:101,615,504...101,621,340
Ensembl chr15:101,615,505...101,621,333 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28698
    cellular process 17677
      intermediate filament-based process 97
        intermediate filament cytoskeleton organization 96
          intermediate filament polymerization or depolymerization 4
            intermediate filament polymerization 1
              negative regulation of intermediate filament polymerization 0
              positive regulation of intermediate filament polymerization 0
              regulation of intermediate filament polymerization + 0
Path 2
Term Annotations click to browse term
  biological_process 28698
    cellular process 17677
      cellular component organization or biogenesis 6827
        cellular component organization 6604
          organelle organization 3629
            cytoskeleton organization 1505
              intermediate filament cytoskeleton organization 96
                intermediate filament polymerization or depolymerization 4
                  intermediate filament polymerization 1
                    negative regulation of intermediate filament polymerization 0
                    positive regulation of intermediate filament polymerization 0
                    regulation of intermediate filament polymerization + 0
paths to the root