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ONTOLOGY REPORT - ANNOTATIONS

Term:intermediate filament polymerization
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Accession:GO:0045107 term browser browse the term
Definition:Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.


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intermediate filament polymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Krt5 keratin 5 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:2179054|PMID:11408584)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:11408584 GO_REF:0000024 GO_REF:0000107 MGI:2179054 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    cellular process 18233
      intermediate filament-based process 94
        intermediate filament cytoskeleton organization 93
          intermediate filament polymerization or depolymerization 4
            intermediate filament polymerization 1
              negative regulation of intermediate filament polymerization 0
              positive regulation of intermediate filament polymerization 0
              regulation of intermediate filament polymerization + 0
Path 2
Term Annotations click to browse term
  biological_process 19553
    cellular process 18233
      cellular component organization or biogenesis 6802
        cellular component organization 6536
          organelle organization 3601
            cytoskeleton organization 1513
              intermediate filament cytoskeleton organization 93
                intermediate filament polymerization or depolymerization 4
                  intermediate filament polymerization 1
                    negative regulation of intermediate filament polymerization 0
                    positive regulation of intermediate filament polymerization 0
                    regulation of intermediate filament polymerization + 0
paths to the root