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ONTOLOGY REPORT - ANNOTATIONS

Term:regulatory T cell differentiation
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Accession:GO:0045066 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulatory T lymphocyte differentiation;   suppressor T cell differentiation;   suppressor T lymphocyte differentiation
 related_synonym: regulatory T cell development


show annotations for term's descendants           Sort by:
regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 CD28 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of		 ISO
IDA		 (PMID:16769892), (PMID:17028180) MGI PMID:16769892 PMID:17028180 GO_REF:0000119 MGI:4834177 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within		 ISO
IMP
IDA		 (PMID:17481928)
(PMID:15100250)		 MGI PMID:15100250 PMID:17481928 GO_REF:0000119 MGI:4834177 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:93,655,831...93,696,792
Ensembl chr10:93,667,417...93,693,950 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of		 ISO
IMP		 (PMID:22079196)
(PMID:16301745), (PMID:18573908)
(PMID:16275384)		 CACAO
MGI		 PMID:16275384 PMID:16301745 PMID:18573908 PMID:22079196 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fut7 fucosyltransferase 7 acts_upstream_of_or_within IMP (PMID:18573908) MGI PMID:18573908 NCBI chr 2:25,312,363...25,316,386
Ensembl chr 2:25,313,279...25,316,386 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain acts_upstream_of IMP (PMID:16227984) MGI PMID:16227984 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within IMP (PMID:11030619) MGI PMID:11030619 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367 		JBrowse link
G Pla2g2d phospholipase A2, group IID acts_upstream_of_or_within IDA (PMID:19564598) MGI PMID:19564598 NCBI chr 4:138,503,046...138,509,363
Ensembl chr 4:138,503,046...138,509,357 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IMP (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 antigen involved_in IMP (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Hspb1 heat shock protein 1 involved_in ISO RGD
MGI		 PMID:30287503 GO_REF:0000096 MGI:4417868 RGD:38549580 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in IMP (MGI:3803082|PMID:18641303) UniProt PMID:18641303 MGI:3803082 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Lag3 lymphocyte-activation gene 3 involved_in IMP (MGI:3510279|PMID:15485628) UniProt PMID:15485628 MGI:3510279 NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668 		JBrowse link
G Mdk midkine involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642 		JBrowse link
G Mir21a microRNA 21a involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir30b microRNA 30b involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr15:68,209,264...68,209,359
Ensembl chr15:68,209,264...68,209,359 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IMP (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Tug1 taurine upregulated gene 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chr11:3,589,313...3,599,021
Ensembl chr11:3,589,785...3,599,673 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 TAS
IMP		 (MGI:3795336|PMID:18368049)
(PMID:16301745), (PMID:18573908)
(PMID:12612578)
(PMID:16275384)		 UniProt
MGI		 PMID:12612578 PMID:16275384 PMID:16301745 PMID:18368049 PMID:18573908 MGI:3795336 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gimap3 GTPase, IMAP family member 3 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:48,741,398...48,747,785
Ensembl chr 6:48,741,398...48,747,785 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 involved_in ISO RGD
MGI		 PMID:15778366 GO_REF:0000096 MGI:4417868 RGD:2303772 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta involved_in ISO (PMID:28467828) UniProt PMID:28467828 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain acts_upstream_of_or_within IMP (PMID:16227984) MGI PMID:16227984 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Klhl25 kelch-like 25 involved_in IDA
ISO		 (MGI:6765767|PMID:34491895) UniProt
MGI		 PMID:34491895 GO_REF:0000119 MGI:4834177 MGI:6765767 NCBI chr 7:75,498,086...75,523,881
Ensembl chr 7:75,498,058...75,523,879 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy/beclin 1 regulator 1 involved_in IMP
ISO		 (MGI:6284097|PMID:30513302) UniProt
MGI		 PMID:30513302 GO_REF:0000119 MGI:4834177 MGI:6284097 NCBI chr 2:91,560,464...91,749,194
Ensembl chr 2:91,560,479...91,749,194 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within IDA (PMID:23589618) MGI PMID:23589618 NCBI chr13:23,661,219...23,673,028
Ensembl chr13:23,661,846...23,673,027 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within IMP (PMID:23793062) MGI PMID:23793062 NCBI chr 8:106,412,642...106,424,827
Ensembl chr 8:106,412,906...106,424,819 		JBrowse link
G Cd46 CD46 antigen, complement regulatory protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:30513302) UniProt PMID:30513302 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 ISO
IDA
IMP		 (PMID:12522256), (PMID:15100250), (PMID:16769892), (PMID:17028180)
(PMID:15780990)		 MGI PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 GO_REF:0000119 MGI:4834177 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 involved_in ISO (PMID:20448110) BHF-UCL PMID:20448110 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G Il2 interleukin 2 involved_in ISO RGD
MGI		 PMID:6233372 GO_REF:0000096 MGI:4417868 RGD:1600097 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in IDA
ISO		 (MGI:5753024|PMID:25778793) UniProt
MGI		 PMID:25778793 GO_REF:0000119 MGI:4834177 MGI:5753024 NCBI chr 7:44,485,712...44,490,233
Ensembl chr 7:44,465,811...44,490,233 		JBrowse link
G Il4i1b interleukin 4 induced 1B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:44,465,794...44,490,228
Ensembl chr 7:44,465,811...44,490,233 		JBrowse link
G Kat5 K(lysine) acetyltransferase 5 involved_in IMP
ISO		 (MGI:5576410|PMID:24835996) UniProt
MGI		 PMID:24835996 GO_REF:0000119 MGI:4834177 MGI:5576410 NCBI chr19:5,653,042...5,661,584
Ensembl chr19:5,653,042...5,660,265 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in IMP (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Mir214 microRNA 214 ISO RGD PMID:30287503 RGD:38549580 NCBI chr 1:162,050,937...162,051,046
Ensembl chr 1:162,050,937...162,051,046 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Sox12 SRY (sex determining region Y)-box 12 involved_in IMP (MGI:6203502|PMID:30190287) UniProt PMID:30190287 MGI:6203502 NCBI chr 2:152,235,531...152,239,966
Ensembl chr 2:152,235,531...152,239,983 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in IMP (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:60,182,630...60,266,073
Ensembl chr10:60,182,630...60,208,463 		JBrowse link
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 CD28 antigen acts_upstream_of_or_within IGI (PMID:21245484) MGI PMID:21245484 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha acts_upstream_of_or_within IMP (PMID:21245393) MGI PMID:21245393 NCBI chr13:61,081,969...61,084,439
Ensembl chr13:61,081,969...61,084,439 		JBrowse link
G Dicer1 dicer 1, ribonuclease type III acts_upstream_of_or_within IMP (PMID:18725527) MGI PMID:18725527 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211 		JBrowse link
G Drosha drosha, ribonuclease type III acts_upstream_of_or_within IMP (PMID:18725527) MGI PMID:18725527 NCBI chr15:12,824,893...12,935,377
Ensembl chr15:12,824,901...12,935,377 		JBrowse link
G Fanca Fanconi anemia, complementation group A acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:24501220) MGI
GO_Central		 PMID:24501220 GO_REF:0000033 NCBI chr 8:123,993,033...124,045,390
Ensembl chr 8:123,995,039...124,045,315 		JBrowse link
G Fancd2 Fanconi anemia, complementation group D2 acts_upstream_of_or_within IMP (PMID:24501220) MGI PMID:24501220 NCBI chr 6:113,508,622...113,573,981
Ensembl chr 6:113,508,643...113,573,978 		JBrowse link
G Kat2a K(lysine) acetyltransferase 2A involved_in IMP (MGI:5926326|PMID:28424240) UniProt PMID:28424240 MGI:5926326 NCBI chr11:100,595,572...100,603,293
Ensembl chr11:100,595,572...100,603,291 		JBrowse link
G Lck lymphocyte protein tyrosine kinase acts_upstream_of_or_within IGI (PMID:21245484) MGI PMID:21245484 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in ISO RGD
MGI		 PMID:25776069 GO_REF:0000096 MGI:4417868 RGD:13442483 NCBI chr 5:121,953,544...121,975,706
Ensembl chr 5:121,953,551...121,975,709 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within IGI (PMID:21245484) MGI PMID:21245484 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      leukocyte activation 1139
        lymphocyte activation 931
          lymphocyte differentiation 503
            T cell differentiation 357
              regulatory T cell differentiation 52
                CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 14
                CD8-positive, alpha-beta regulatory T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 10
                positive regulation of regulatory T cell differentiation + 28
                regulation of regulatory T cell differentiation + 47
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      cellular developmental process 5063
        cell differentiation 5062
          cell development 3447
            hemopoiesis 1161
              leukocyte differentiation 751
                mononuclear cell differentiation 607
                  lymphocyte differentiation 503
                    T cell differentiation 357
                      regulatory T cell differentiation 52
                        CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 14
                        CD8-positive, alpha-beta regulatory T cell differentiation 0
                        negative regulation of regulatory T cell differentiation + 10
                        positive regulation of regulatory T cell differentiation + 28
                        regulation of regulatory T cell differentiation + 47
paths to the root