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ONTOLOGY REPORT - ANNOTATIONS

Term:cytotoxic T cell differentiation
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Accession:GO:0045065 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: cytotoxic T lymphocyte selection;   cytotoxic T-cell selection
 related_synonym: cytotoxic T cell development


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cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD8A CD8 subunit alpha involved_in
acts_upstream_of_or_within 		IBA
ISO 		(PMID:1673361) GO_Central
MGI		 PMID:1673361 GO_REF:0000033 NCBI chr 3:57,999,228...58,029,768
Ensembl chr 3:57,998,891...58,029,760 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100517285 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr 6:58,996,449...59,001,088 JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SART1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,355,690...6,373,342
Ensembl chr 2:6,354,908...6,373,272 		JBrowse link
G TNFSF9 TNF superfamily member 9 involved_in ISO
IBA 		RGD
GO_Central		 PMID:19187795 GO_REF:0000033 RGD:2317344 NCBI chr 2:72,578,811...72,582,834
Ensembl chr 2:72,578,821...72,582,745 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    immune system process 2590
      leukocyte activation 1061
        lymphocyte activation 872
          lymphocyte differentiation 455
            T cell differentiation 343
              cytotoxic T cell differentiation 4
                CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                negative regulation of cytotoxic T cell differentiation 1
                positive regulation of cytotoxic T cell differentiation 2
                regulation of cytotoxic T cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 18945
    developmental process 6804
      cellular developmental process 4591
        cell differentiation 4590
          cell development 3258
            hemopoiesis 1050
              leukocyte differentiation 677
                mononuclear cell differentiation 550
                  lymphocyte differentiation 455
                    T cell differentiation 343
                      cytotoxic T cell differentiation 4
                        CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                        negative regulation of cytotoxic T cell differentiation 1
                        positive regulation of cytotoxic T cell differentiation 2
                        regulation of cytotoxic T cell differentiation + 3
paths to the root