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ONTOLOGY REPORT - ANNOTATIONS

Term:cytotoxic T cell differentiation
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Accession:GO:0045065 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: cytotoxic T lymphocyte selection;   cytotoxic T-cell selection
 related_synonym: cytotoxic T cell development

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cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD8A CD8 subunit alpha acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:1673361) MGI
TreeGrafter		 PMID:1673361 GO_REF:0000118 NCBI chr14:18,878,013...18,885,183
Ensembl chr14:18,878,622...18,883,885 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr 6:47,299,764...47,333,711 JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SART1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,279,821...8,296,282
Ensembl chr 1:8,275,123...8,296,245 		JBrowse link
G TNFSF9 TNF superfamily member 9 involved_in ISO
IEA 		RGD
TreeGrafter		 PMID:19187795 GO_REF:0000118 RGD:2317344 NCBI chr 6:6,131,157...6,136,345
Ensembl chr 6:6,131,571...6,135,463 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19826
    immune system process 2689
      leukocyte activation 1045
        lymphocyte activation 857
          lymphocyte differentiation 461
            T cell differentiation 342
              cytotoxic T cell differentiation 4
                CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                negative regulation of cytotoxic T cell differentiation 1
                positive regulation of cytotoxic T cell differentiation 2
                regulation of cytotoxic T cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 19826
    developmental process 6885
      cellular developmental process 4615
        cell differentiation 4614
          cell development 3292
            hemopoiesis 1063
              leukocyte differentiation 690
                mononuclear cell differentiation 560
                  lymphocyte differentiation 461
                    T cell differentiation 342
                      cytotoxic T cell differentiation 4
                        CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                        negative regulation of cytotoxic T cell differentiation 1
                        positive regulation of cytotoxic T cell differentiation 2
                        regulation of cytotoxic T cell differentiation + 3
paths to the root