Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:cytotoxic T cell differentiation
go back to main search page
Accession:GO:0045065 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: cytotoxic T lymphocyte selection;   cytotoxic T-cell selection
 related_synonym: cytotoxic T cell development


show annotations for term's descendants           Sort by:
cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD8A CD8 subunit alpha acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:1673361) MGI
TreeGrafter		 PMID:1673361 GO_REF:0000118 NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr19:51,606,681...51,612,751 JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SART1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,326,262...61,343,475
Ensembl chr11:64,654,470...64,670,720 		JBrowse link
G TNFSF9 TNF superfamily member 9 involved_in ISO
IEA 		RGD
TreeGrafter		 PMID:19187795 GO_REF:0000118 RGD:2317344 NCBI chr19:5,558,021...5,562,901
Ensembl chr19:6,476,941...6,483,352 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2524
      leukocyte activation 1007
        lymphocyte activation 819
          lymphocyte differentiation 436
            T cell differentiation 330
              cytotoxic T cell differentiation 4
                CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                negative regulation of cytotoxic T cell differentiation 1
                positive regulation of cytotoxic T cell differentiation 2
                regulation of cytotoxic T cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 6695
      cellular developmental process 4505
        cell differentiation 4504
          cell development 3203
            hemopoiesis 1032
              leukocyte differentiation 665
                mononuclear cell differentiation 537
                  lymphocyte differentiation 436
                    T cell differentiation 330
                      cytotoxic T cell differentiation 4
                        CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                        negative regulation of cytotoxic T cell differentiation 1
                        positive regulation of cytotoxic T cell differentiation 2
                        regulation of cytotoxic T cell differentiation + 3
paths to the root