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ONTOLOGY REPORT - ANNOTATIONS


Term:cytotoxic T cell differentiation
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Accession:GO:0045065 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: cytotoxic T lymphocyte selection;   cytotoxic T-cell selection
 related_synonym: cytotoxic T cell development



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cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd8a CD8a molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857149 (MGI:1933767|PMID:1673361)
RGD PMID:1673361 PMID:21873635 MGI:1933767, RGD:13792537 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) RGD PMID:16493035 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in ISO (PMID:10209962) RGD PMID:10209962 NCBI chr 1:202,690,472...202,699,136
Ensembl chr 1:202,690,459...202,699,136
JBrowse link
G Tnfsf9 TNF superfamily member 9 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:19187795 PMID:21873635 RGD:2317344, RGD:13792537 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      leukocyte activation 1025
        lymphocyte activation 840
          lymphocyte differentiation 426
            T cell differentiation 306
              cytotoxic T cell differentiation 4
                CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                negative regulation of cytotoxic T cell differentiation 1
                positive regulation of cytotoxic T cell differentiation 2
                regulation of cytotoxic T cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            immune system development 1129
              hematopoietic or lymphoid organ development 1061
                hemopoiesis 1012
                  leukocyte differentiation 634
                    mononuclear cell differentiation 485
                      lymphocyte differentiation 426
                        T cell differentiation 306
                          cytotoxic T cell differentiation 4
                            CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                            negative regulation of cytotoxic T cell differentiation 1
                            positive regulation of cytotoxic T cell differentiation 2
                            regulation of cytotoxic T cell differentiation + 3
paths to the root