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ONTOLOGY REPORT - ANNOTATIONS

Term:cytotoxic T cell differentiation
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Accession:GO:0045065 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: cytotoxic T lymphocyte selection;   cytotoxic T-cell selection
 related_synonym: cytotoxic T cell development


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cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd8a CD8 subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1857149 (MGI:1933767|PMID:1673361)
PMID:21873635		 RGD PMID:1673361 PMID:21873635 MGI:1933767, RGD:13792537 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) RGD PMID:16493035 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in ISO (PMID:10209962) RGD PMID:10209962 NCBI chr 1:202,690,472...202,699,136
Ensembl chr 1:202,690,459...202,699,136 		JBrowse link
G Tnfsf9 TNF superfamily member 9 involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:19187795 PMID:21873635 RGD:2317344, RGD:13792537 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    immune system process 2664
      leukocyte activation 1028
        lymphocyte activation 833
          lymphocyte differentiation 442
            T cell differentiation 318
              cytotoxic T cell differentiation 4
                CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                negative regulation of cytotoxic T cell differentiation 1
                positive regulation of cytotoxic T cell differentiation 2
                regulation of cytotoxic T cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 19553
    developmental process 6909
      cellular developmental process 4642
        cell differentiation 4641
          cell development 3235
            hemopoiesis 1052
              leukocyte differentiation 666
                mononuclear cell differentiation 499
                  lymphocyte differentiation 442
                    T cell differentiation 318
                      cytotoxic T cell differentiation 4
                        CD8-positive, alpha-beta cytotoxic T cell differentiation 0
                        negative regulation of cytotoxic T cell differentiation 1
                        positive regulation of cytotoxic T cell differentiation 2
                        regulation of cytotoxic T cell differentiation + 3
paths to the root