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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 1 cell differentiation
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Accession:GO:0045063 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T-helper 1 cell development


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T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in IMP
ISO		 (MGI:6195365|PMID:29987160) UniProt
MGI		 PMID:29987160 GO_REF:0000119 MGI:4834177 MGI:6195365 NCBI chr 6:127,538,299...127,651,197
Ensembl chr 6:127,538,301...127,651,211 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma acts_upstream_of_or_within TAS (PMID:12213961) MGI PMID:12213961 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of IGI
IMP		 (PMID:16424184) MGI PMID:16424184 NCBI chr 1:184,459,340...184,464,690
Ensembl chr 1:184,459,337...184,464,816 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within IMP (PMID:10227969) MGI PMID:10227969 NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014 		JBrowse link
G Il4ra interleukin 4 receptor, alpha acts_upstream_of IGI (PMID:16424184) MGI PMID:16424184 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IDA (MGI:4834989|PMID:18579517) UniProt PMID:18579517 MGI:4834989 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005 		JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta involved_in IMP (PMID:31182790) MGI PMID:31182790 NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B acts_upstream_of_or_within IMP (PMID:16081776) MGI PMID:16081776 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A involved_in IMP (MGI:3574161|PMID:15780988) UniProt PMID:15780988 MGI:3574161 NCBI chr 3:88,343,266...88,368,500
Ensembl chr 3:88,343,266...88,368,489 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in IDA (MGI:6294180|PMID:25946230) UniProt PMID:25946230 MGI:6294180 NCBI chr11:80,701,192...80,712,859
Ensembl chr11:80,701,001...80,712,859 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IMP (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chr 7:142,520,559...142,523,001
Ensembl chr 7:142,520,566...142,523,001 		JBrowse link
G Il4ra interleukin 4 receptor, alpha acts_upstream_of_or_within IGI (PMID:16424184) MGI PMID:16424184 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Jak3 Janus kinase 3 involved_in IMP (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IDA (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in IDA (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in IC (MGI:3699670|PMID:14662900) BHF-UCL PMID:14662900 MGI:3699670 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IC (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within IGI
IMP		 (PMID:16424184) MGI PMID:16424184 NCBI chr 1:184,459,340...184,464,690
Ensembl chr 1:184,459,337...184,464,816 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in TAS (MGI:5319622|PMID:11244049) UniProt PMID:11244049 MGI:5319622 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 acts_upstream_of_or_within IMP (PMID:11894097) MGI PMID:11894097 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IDA (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chr17:87,414,707...87,445,153
Ensembl chr17:87,415,107...87,445,267 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within IGI (PMID:20706986) MGI PMID:20706986 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IMP (PMID:26410627) MGI PMID:26410627 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Spn sialophorin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IGI (PMID:20706986) MGI PMID:20706986 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Tbx21 T-box 21 involved_in IDA (MGI:1354779|PMID:10761931) UniProt PMID:10761931 MGI:1354779 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    response to stimulus 10772
      immune response 2180
        adaptive immune response 643
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 496
            T-helper 1 type immune response 52
              T-helper 1 cell differentiation 28
                T-helper 1 cell lineage commitment 5
                negative regulation of T-helper 1 cell differentiation 4
                positive regulation of T-helper 1 cell differentiation 8
                regulation of T-helper 1 cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      cellular developmental process 5063
        cell differentiation 5062
          cell development 3447
            hemopoiesis 1161
              leukocyte differentiation 751
                mononuclear cell differentiation 607
                  lymphocyte differentiation 503
                    T cell differentiation 357
                      T cell differentiation involved in immune response 92
                        alpha-beta T cell differentiation involved in immune response 85
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 84
                            T-helper cell differentiation 82
                              T-helper 1 cell differentiation 28
                                T-helper 1 cell lineage commitment 5
                                negative regulation of T-helper 1 cell differentiation 4
                                positive regulation of T-helper 1 cell differentiation 8
                                regulation of T-helper 1 cell differentiation + 13
paths to the root