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ONTOLOGY REPORT - ANNOTATIONS


Term:protein insertion into ER membrane
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Accession:GO:0045048 term browser browse the term
Definition:The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
Synonyms:exact_synonym: integral ER membrane protein localization;   integral ER membrane protein positioning;   localization of protein in ER membrane;   positioning of protein in ER membrane;   protein insertion into endoplasmic reticulum membrane;   protein-ER insertion;   protein-endoplasmic reticulum insertion


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protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc47 coiled-coil domain containing 47 involved_in IEA
ISO
GO_REF:0000107
(PMID:32814900)
Ensembl
RGD
PMID:32814900 GO_REF:0000107 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in ISO (PMID:31417168), (PMID:32187542) RGD PMID:31417168 PMID:32187542 NCBI chr11:36,497,513...36,511,445
Ensembl chr11:36,497,509...36,511,535
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:17,469,112...17,486,709
Ensembl chr12:17,469,112...17,486,157
JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:228,544,418...228,546,599
Ensembl chr 2:228,544,418...228,546,599
JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in ISO
IBA
(PMID:27499293)
PMID:21873635
RGD PMID:27499293, PMID:21873635 RGD:13792537 NCBI chr 9:27,117,861...27,192,166
Ensembl chr 9:27,117,869...27,192,135
JBrowse link
G Wdr83os WD repeat domain 83 opposite strand involved_in ISO (PMID:32814900) RGD PMID:32814900 NCBI chr19:26,194,336...26,195,837
Ensembl chr19:26,194,465...26,195,837
JBrowse link
protein insertion into ER membrane by stop-transfer membrane-anchor sequence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr 1:100,495,112...100,501,468
Ensembl chr 1:100,495,119...100,501,437
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
Ensembl
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:82,338,639...82,377,389
Ensembl chr 7:82,338,663...82,377,109
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 3:103,852,139...103,857,172
Ensembl chr 3:103,852,139...103,857,158
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 3:103,945,276...103,955,970
Ensembl chr 3:103,945,329...103,956,007
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr15:34,258,940...34,263,156
Ensembl chr15:34,256,374...34,263,224
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr  X:158,966,694...158,978,995
Ensembl chr  X:158,966,673...158,978,995
JBrowse link
tail-anchored membrane protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag6 BAG cochaperone 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:20676083), (PMID:25535373)
UniProt
RGD
PMID:20676083 PMID:25535373 GO_REF:0000024 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Camlg calcium modulating ligand involved_in ISO
IDA
(PMID:23041287), (PMID:27226539) RGD PMID:23041287 PMID:27226539, PMID:23041287 RGD:42721997 NCBI chr17:9,523,792...9,534,683
Ensembl chr17:9,523,795...9,534,653
JBrowse link
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231)
UniProt
RGD
PMID:29242231 GO_REF:0000024 NCBI chr 1:100,495,112...100,501,468
Ensembl chr 1:100,495,119...100,501,437
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:29242231)
Ensembl
UniProt
RGD
PMID:29242231 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:82,338,639...82,377,389
Ensembl chr 7:82,338,663...82,377,109
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:103,852,139...103,857,172
Ensembl chr 3:103,852,139...103,857,158
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:103,945,276...103,955,970
Ensembl chr 3:103,945,329...103,956,007
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr15:34,258,940...34,263,156
Ensembl chr15:34,256,374...34,263,224
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in IBA
IDA
ISO
PMID:21873635
PMID:23041287
(PMID:23041287), (PMID:27226539)
RGD PMID:23041287 PMID:27226539, PMID:21873635, PMID:23041287 RGD:13792537, RGD:42721997 NCBI chr11:36,497,513...36,511,445
Ensembl chr11:36,497,509...36,511,535
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase involved_in ISO
IDA
(PMID:23041287), (PMID:25535373)
PMID:27226539
RGD PMID:23041287 PMID:25535373, PMID:23041287, PMID:27226539 RGD:42721997, RGD:42721993 NCBI chr19:26,133,024...26,142,637
Ensembl chr19:26,133,027...26,141,111
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:20676083), (PMID:25535373) RGD PMID:20676083 PMID:25535373 NCBI chr12:17,469,112...17,486,709
Ensembl chr12:17,469,112...17,486,157
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr  X:158,966,694...158,978,995
Ensembl chr  X:158,966,673...158,978,995
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:25535373)
UniProt
RGD
PMID:25535373 GO_REF:0000024 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Ubl4a ubiquitin-like 4A involved_in ISO
ISS
(PMID:20676083), (PMID:25535373)
GO_REF:0000024
RGD
UniProt
PMID:20676083 PMID:25535373 GO_REF:0000024 NCBI chr  X:156,340,919...156,343,771
Ensembl chr  X:156,340,925...156,343,777
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      cellular component organization or biogenesis 6727
        cellular component organization 6482
          organelle organization 4058
            endoplasmic reticulum organization 92
              protein insertion into ER membrane 22
                protein insertion into ER membrane by GPI attachment sequence 0
                protein insertion into ER membrane by N-terminal cleaved signal sequence 0
                protein insertion into ER membrane by internal uncleaved signal-anchor sequence 0
                protein insertion into ER membrane by stop-transfer membrane-anchor sequence 10
                tail-anchored membrane protein insertion into ER membrane 17
Path 2
Term Annotations click to browse term
  biological_process 19610
    localization 6453
      cellular localization 2991
        cellular macromolecule localization 1858
          cellular protein localization 1844
            protein localization to membrane 619
              establishment of protein localization to membrane 266
                protein insertion into membrane 53
                  protein insertion into ER membrane 22
                    protein insertion into ER membrane by GPI attachment sequence 0
                    protein insertion into ER membrane by N-terminal cleaved signal sequence 0
                    protein insertion into ER membrane by internal uncleaved signal-anchor sequence 0
                    protein insertion into ER membrane by stop-transfer membrane-anchor sequence 10
                    tail-anchored membrane protein insertion into ER membrane 17
paths to the root