Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:protein insertion into ER membrane
go back to main search page
Accession:GO:0045048 term browser browse the term
Definition:The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
Synonyms:exact_synonym: integral ER membrane protein localization;   integral ER membrane protein positioning;   localization of protein in ER membrane;   positioning of protein in ER membrane;   protein insertion into endoplasmic reticulum membrane;   protein-ER insertion;   protein-endoplasmic reticulum insertion



show annotations for term's descendants           Sort by:
protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc47 coiled-coil domain containing 47 involved_in ISO
ISS
(PMID:32814900)
GO_REF:0000024
RGD
UniProt
PMID:32814900 GO_REF:0000024 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in ISO (PMID:31417168), (PMID:32187542) RGD PMID:31417168 PMID:32187542 NCBI chr11:35,438,555...35,460,156
Ensembl chr11:35,445,815...35,459,973
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO
IBA
(PMID:32395830)
GO_REF:0000033
RGD
GO_Central
PMID:32395830 GO_REF:0000033 NCBI chr12:15,377,009...15,394,238
Ensembl chr12:15,377,009...15,394,053
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:8616892)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:8616892 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925
JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in ISO
IBA
IEA
ISS
(PMID:8616892)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000024
GO_REF:0000107
RGD
GO_Central
TreeGrafter
UniProt
Ensembl
PMID:8616892 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971
JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in ISO
IBA
(PMID:27499293)
GO_REF:0000033
RGD
GO_Central
PMID:27499293 GO_REF:0000033 NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689
JBrowse link
G Wdr83os WD repeat domain 83 opposite strand involved_in ISO (PMID:32814900) RGD PMID:32814900 NCBI chr19:23,075,373...23,076,745
Ensembl chr19:23,075,376...23,076,894
JBrowse link
multi-pass transmembrane protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc47 coiled-coil domain containing 47 involved_in ISS
ISO
GO_REF:0000024
(PMID:36261522)
(PMID:36261528)
UniProt
RGD
PMID:36261522 PMID:36261528 GO_REF:0000024 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
JBrowse link
G Ncln nicalin involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:36261522)
(PMID:36261528)
Ensembl
UniProt
RGD
PMID:36261522 PMID:36261528 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:8,211,978...8,221,938
Ensembl chr 7:8,211,996...8,221,934
JBrowse link
G Nomo1 Nodal modulator 1 involved_in ISO (PMID:36261522) RGD PMID:36261522 NCBI chr 1:96,505,460...96,556,280
Ensembl chr 1:96,505,484...96,556,279
JBrowse link
G Rab5if RAB5 interacting factor involved_in ISO (PMID:36261522)
(PMID:36261528)
RGD PMID:36261522 PMID:36261528 NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:36261522)
(PMID:36261528)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:36261522 PMID:36261528 GO_REF:0000024 GO_REF:0000107 NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555
JBrowse link
G Tmem147 transmembrane protein 147 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:36261522)
(PMID:36261528)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:36261522 PMID:36261528 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:85,977,028...85,978,848
Ensembl chr 1:85,977,025...85,978,868
JBrowse link
G Wdr83os WD repeat domain 83 opposite strand involved_in ISO (PMID:36261522)
(PMID:36261528)
RGD PMID:36261522 PMID:36261528 NCBI chr19:23,075,373...23,076,745
Ensembl chr19:23,075,376...23,076,894
JBrowse link
protein insertion into ER membrane by stop-transfer membrane-anchor sequence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29242231), (PMID:29809151), (PMID:30415835) RGD PMID:29242231 PMID:29809151 PMID:30415835 NCBI chr 5:151,608,557...151,633,888
Ensembl chr 5:151,608,568...151,633,888
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:29242231), (PMID:29809151), (PMID:30415835)
UniProt
Ensembl
RGD
PMID:29242231 PMID:29809151 PMID:30415835 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:29809151), (PMID:30415835), (PMID:33964204)
UniProt
RGD
PMID:29242231 PMID:29809151 PMID:30415835 PMID:33964204 GO_REF:0000024 NCBI chr 7:74,587,196...74,624,163
Ensembl chr 7:74,587,175...74,625,189
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29242231 PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29242231), (PMID:29809151), (PMID:30415835) RGD PMID:29242231 PMID:29809151 PMID:30415835 NCBI chr 3:99,169,711...99,174,730
Ensembl chr 3:99,169,711...99,174,729
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29242231), (PMID:29809151), (PMID:30415835) RGD PMID:29242231 PMID:29809151 PMID:30415835 NCBI chr10:57,794,072...57,795,671
Ensembl chr10:57,793,685...57,796,217
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29242231), (PMID:29809151), (PMID:30415835) RGD PMID:29242231 PMID:29809151 PMID:30415835 NCBI chr 3:99,263,933...99,274,365
Ensembl chr 3:99,263,980...99,274,360
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29242231 PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29242231 PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr15:29,071,881...29,076,098
Ensembl chr15:29,071,883...29,076,098
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29242231 PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr  X:134,408,463...134,420,798
Ensembl chr  X:134,408,466...134,420,729
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:33964204)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:33964204 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905
JBrowse link
tail-anchored membrane protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag6 BAG cochaperone 6 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:20676083), (PMID:25535373)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20676083 PMID:25535373 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657
JBrowse link
G Camlg calcium modulating ligand involved_in ISO
IDA
IEA
IBA
(PMID:23041287), (PMID:27226539)
GO_REF:0000118
GO_REF:0000033
RGD
TreeGrafter
GO_Central
PMID:23041287 PMID:27226539 PMID:23041287 GO_REF:0000033 GO_REF:0000118, RGD:42721997 NCBI chr17:8,992,697...9,003,576
Ensembl chr17:8,992,696...9,003,552
JBrowse link
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 5:151,608,557...151,633,888
Ensembl chr 5:151,608,568...151,633,888
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:29242231)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29242231 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr 7:74,587,196...74,624,163
Ensembl chr 7:74,587,175...74,625,189
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:99,169,711...99,174,730
Ensembl chr 3:99,169,711...99,174,729
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29242231), (PMID:34918864) RGD PMID:29242231 PMID:34918864 NCBI chr10:57,794,072...57,795,671
Ensembl chr10:57,793,685...57,796,217
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:99,263,933...99,274,365
Ensembl chr 3:99,263,980...99,274,360
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr15:29,071,881...29,076,098
Ensembl chr15:29,071,883...29,076,098
JBrowse link
G ENSRNOG00000066262 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr  X:34,823,863...34,824,157 JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in ISO
IDA
IEA
IBA
(PMID:23041287), (PMID:27226539)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000118
RGD
InterPro
GO_Central
TreeGrafter
PMID:23041287 PMID:27226539 PMID:23041287 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118, RGD:42721997 NCBI chr11:35,438,555...35,460,156
Ensembl chr11:35,445,815...35,459,973
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase involved_in IDA
IBA
ISO
PMID:27226539
GO_REF:0000033
(PMID:23041287), (PMID:25535373), (PMID:31461301)
GO_Central
RGD
PMID:23041287 PMID:25535373 PMID:31461301 PMID:27226539 PMID:23041287 GO_REF:0000033, RGD:42721993, RGD:42721997 NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:20676083), (PMID:25535373) RGD PMID:20676083 PMID:25535373 NCBI chr12:15,377,009...15,394,238
Ensembl chr12:15,377,009...15,394,053
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231), (PMID:34918864)
UniProt
RGD
PMID:29242231 PMID:34918864 GO_REF:0000024 NCBI chr  X:134,408,463...134,420,798
Ensembl chr  X:134,408,466...134,420,729
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:25535373)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:25535373 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458
JBrowse link
G Slc10a3 solute carrier family 10, member 3 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr  X:152,154,757...152,158,563
Ensembl chr  X:152,151,076...152,162,958
JBrowse link
G Ubl4a ubiquitin-like 4A involved_in ISO
IBA
IEA
ISS
(PMID:20676083), (PMID:25535373)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
RGD
GO_Central
Ensembl
UniProt
PMID:20676083 PMID:25535373 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:152,151,242...152,154,094
Ensembl chr  X:152,151,460...152,154,069
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cellular component organization or biogenesis 7290
        cellular component organization 6980
          organelle organization 3887
            endoplasmic reticulum organization 102
              protein insertion into ER membrane 30
                multi-pass transmembrane protein insertion into ER membrane 7
                protein insertion into ER membrane by N-terminal cleaved signal sequence 0
                protein insertion into ER membrane by internal uncleaved signal-anchor sequence 0
                protein insertion into ER membrane by stop-transfer membrane-anchor sequence 11
                tail-anchored membrane protein insertion into ER membrane 19
Path 2
Term Annotations click to browse term
  biological_process 20413
    localization 5751
      cellular localization 3776
        cellular macromolecule localization 2760
          protein localization 2748
            protein localization to membrane 699
              establishment of protein localization to membrane 305
                protein insertion into membrane 47
                  protein insertion into ER membrane 30
                    multi-pass transmembrane protein insertion into ER membrane 7
                    protein insertion into ER membrane by N-terminal cleaved signal sequence 0
                    protein insertion into ER membrane by internal uncleaved signal-anchor sequence 0
                    protein insertion into ER membrane by stop-transfer membrane-anchor sequence 11
                    tail-anchored membrane protein insertion into ER membrane 19
paths to the root