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ONTOLOGY REPORT - ANNOTATIONS


Term:protein targeting to ER
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Accession:GO:0045047 term browser browse the term
Definition:The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
Synonyms:exact_synonym: protein targeting to endoplasmic reticulum;   protein-ER targeting;   protein-endoplasmic reticulum targeting


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protein targeting to ER term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arxes2 adipocyte-related X-chromosome expressed sequence 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:106,522,900...106,524,832
Ensembl chr  X:106,523,278...106,523,820
Ensembl chr  X:106,523,278...106,523,820
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO (PMID:23233672) RGD PMID:23233672 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (MGI:6467687|PMID:24478453) RGD PMID:24478453 MGI:6467687 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G MGC109340 similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:106,487,872...106,489,391
Ensembl chr  X:106,487,870...106,489,387
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISO (PMID:18480044) RGD PMID:18480044 NCBI chr 4:120,453,577...120,467,932
Ensembl chr 4:120,453,581...120,467,932
JBrowse link
G Sec61g SEC61 translocon subunit gamma involved_in ISO UniProtKB:P35179 (PMID:8107851) RGD PMID:8107851 NCBI chr14:99,774,589...99,780,964
Ensembl chr14:99,774,589...99,780,964
JBrowse link
G Spcs1 signal peptidase complex subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:7,080,389...7,081,957
Ensembl chr16:7,080,454...7,082,193
JBrowse link
G Spcs2 signal peptidase complex subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:164,829,896...164,849,749
Ensembl chr 1:164,829,896...164,849,749
JBrowse link
G Spcs3 signal peptidase complex subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:40,050,862...40,056,296
Ensembl chr16:40,050,734...40,058,822
JBrowse link
G Srp14 signal recognition particle 14 involved_in IBA
ISO
PMID:21873635
(PMID:18089836)
RGD PMID:18089836, PMID:21873635 RGD:13792537 NCBI chr 3:110,245,936...110,249,627
Ensembl chr 3:110,245,936...110,249,627
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:18089836)
(PMID:16469117)
RGD PMID:16469117 PMID:18089836 NCBI chr 6:75,996,629...76,035,768
Ensembl chr 6:75,996,643...76,034,083
JBrowse link
G Srpra SRP receptor subunit alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Srprb SRP receptor subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:111,673,479...111,687,426 JBrowse link
G Zfand2a zinc finger AN1-type containing 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link
G Zfand2b zinc finger AN1-type containing 2B involved_in ISO
IBA
(PMID:26692333)
PMID:21873635
(MGI:5780912|PMID:26692333)
RGD PMID:26692333, PMID:21873635 MGI:5780912, RGD:13792537 NCBI chr 9:82,370,887...82,373,843
Ensembl chr 9:82,370,924...82,373,839
JBrowse link
posttranslational protein targeting to endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:21975012) RGD PMID:21975012 NCBI chr 3:150,188,275...150,227,453
Ensembl chr 3:150,188,455...150,227,405
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 acts_upstream_of_or_within ISO MGI:5911419|MGI:6117117 (MGI:5817553|PMID:27458190) RGD PMID:27458190 MGI:5817553 NCBI chr11:36,497,513...36,511,445
Ensembl chr11:36,497,509...36,511,535
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:26,133,024...26,142,637
Ensembl chr19:26,133,027...26,141,111
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 acts_upstream_of_or_within ISO (MGI:3640889|PMID:16815997) RGD PMID:16815997 MGI:3640889 NCBI chr 5:141,039,455...141,363,524
Ensembl chr 5:141,039,468...141,363,524
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 4:120,453,577...120,467,932
Ensembl chr 4:120,453,581...120,467,932
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 2:116,188,736...116,225,510
Ensembl chr 2:116,189,862...116,219,750
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22375059)
MGI:5442171 (MGI:5494355|PMID:22375059)
RGD PMID:22375059, PMID:21873635 MGI:5494355, RGD:13792537 NCBI chr20:47,494,270...47,563,222
Ensembl chr20:47,494,270...47,563,222
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:34,185,938...34,222,428
Ensembl chr 2:34,186,091...34,219,802
JBrowse link
posttranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028668.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr17:79,829,305...79,829,511 JBrowse link
G AABR07041141.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:120,521,665...120,521,871 JBrowse link
G AABR07048012.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:56,751,657...56,753,832 JBrowse link
G AABR07048013.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:56,769,347...56,771,522 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:29719251)
UniProt
RGD
PMID:29719251 GO_REF:0000024 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G LOC100362376 LRRGT00025-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:120,521,595...120,521,921 JBrowse link
G LOC108348617 protein transport protein Sec61 subunit gamma pseudogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:79,829,305...79,829,511 JBrowse link
G LOC499136 LRRGT00021 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:97,783,806...97,785,490
Ensembl chr 1:97,783,806...97,785,490
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:29719251)
UniProt
RGD
PMID:29719251, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:120,453,577...120,467,932
Ensembl chr 4:120,453,581...120,467,932
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:76,358,947...76,385,860
Ensembl chr17:76,358,944...76,385,103
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:63,192,322...63,200,532
Ensembl chr 5:63,192,298...63,200,508
JBrowse link
G Sec61g SEC61 translocon subunit gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:99,774,589...99,780,964
Ensembl chr14:99,774,589...99,780,964
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor involved_in ISO
IBA
(PMID:29719251)
PMID:21873635
RGD PMID:29719251, PMID:21873635 RGD:13792537 NCBI chr 2:116,188,736...116,225,510
Ensembl chr 2:116,189,862...116,219,750
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in ISO (PMID:29719251) RGD PMID:29719251 NCBI chr20:47,494,270...47,563,222
Ensembl chr20:47,494,270...47,563,222
JBrowse link
SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC108348180 signal recognition particle subunit SRP72-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:33,958,495...33,960,973
Ensembl chr14:33,447,591...33,560,503
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 4:120,453,577...120,467,932
Ensembl chr 4:120,453,581...120,467,932
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22375059)
MGI:5442171 (MGI:5494355|PMID:22375059)
RGD PMID:22375059, PMID:21873635 MGI:5494355, RGD:13792537 NCBI chr20:47,494,270...47,563,222
Ensembl chr20:47,494,270...47,563,222
JBrowse link
G Srp14 signal recognition particle 14 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:110,245,936...110,249,627
Ensembl chr 3:110,245,936...110,249,627
JBrowse link
G Srp68 signal recognition particle 68 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:105,123,324...105,150,080
Ensembl chr10:105,123,327...105,228,547
JBrowse link
G Srp9 signal recognition particle 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447
JBrowse link
G Srpra SRP receptor subunit alpha involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Ssr3 signal sequence receptor subunit 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:156,010,997...156,023,853
Ensembl chr 2:156,011,002...156,014,527
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srp19 signal recognition particle 19 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,114,822...27,121,062
Ensembl chr18:27,114,822...27,121,059
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:16469117) RGD PMID:16469117 NCBI chr 6:75,996,629...76,035,768
Ensembl chr 6:75,996,643...76,034,083
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,453,577...120,467,932
Ensembl chr 4:120,453,581...120,467,932
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:76,358,947...76,385,860
Ensembl chr17:76,358,944...76,385,103
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:63,192,322...63,200,532
Ensembl chr 5:63,192,298...63,200,508
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO
IBA
(PMID:8521805)
PMID:21873635
RGD PMID:8521805, PMID:21873635 RGD:13792537 NCBI chr 6:75,996,629...76,035,768
Ensembl chr 6:75,996,643...76,034,083
JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IEA
ISO
GO_REF:0000002
(PMID:8698819)
InterPro
RGD
PMID:8698819 GO_REF:0000002 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:228,544,418...228,546,599
Ensembl chr 2:228,544,418...228,546,599
JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:27,117,861...27,192,166
Ensembl chr 9:27,117,869...27,192,135
JBrowse link
G Zfand2b zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) RGD PMID:24160817 NCBI chr 9:82,370,887...82,373,843
Ensembl chr 9:82,370,924...82,373,839
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    localization 6449
      cellular localization 2983
        intracellular transport 1507
          intracellular protein transport 899
            protein targeting 318
              protein targeting to ER 42
                SRP-dependent cotranslational protein targeting to membrane + 16
                posttranslational protein targeting to endoplasmic reticulum membrane + 20
Path 2
Term Annotations click to browse term
  biological_process 19599
    localization 6449
      macromolecule localization 3003
        protein localization 2563
          cellular protein localization 1837
            protein localization to organelle 935
              establishment of protein localization to organelle 453
                establishment of protein localization to endoplasmic reticulum 46
                  protein targeting to ER 42
                    SRP-dependent cotranslational protein targeting to membrane + 16
                    posttranslational protein targeting to endoplasmic reticulum membrane + 20
paths to the root