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ONTOLOGY REPORT - ANNOTATIONS

Term:early endosome to late endosome transport
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Accession:GO:0045022 term browser browse the term
Definition:The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
Synonyms:related_synonym: endosome maturation


show annotations for term's descendants           Sort by:
early endosome to late endosome transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aktip AKT interacting protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18799622)		 UniProt
Ensembl
RGD		 PMID:18799622 GO_REF:0000024 GO_REF:0000107 NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663 		JBrowse link
G Ankrd27 ankyrin repeat domain 27 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:16525121)
GO_REF:0000033		 RGD
GO_Central		 PMID:16525121 GO_REF:0000033 NCBI chr 1:88,251,216...88,303,615
Ensembl chr 1:88,251,226...88,303,615 		JBrowse link
G Atg14 autophagy related 14 involved_in ISO (PMID:14617358) RGD PMID:14617358 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113 		JBrowse link
G Becn1 beclin 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:14617358), (PMID:26783301)		 UniProt
RGD		 PMID:14617358 PMID:26783301 GO_REF:0000024 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5607239|PMID:18400107)		 UniProt
RGD		 PMID:18400107 GO_REF:0000024 MGI:5607239 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Fhip1b FHF complex subunit HOOK interacting protein 1B involved_in ISO
IBA
IEA
ISS		 (PMID:18799622)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:18799622 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:159,718,679...159,748,449
Ensembl chr 1:159,726,004...159,748,408 		JBrowse link
G Flna filamin A acts_upstream_of_or_within ISO (PMID:9412467) RGD PMID:9412467 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Hap1 huntingtin-associated protein 1 TAS RGD PMID:12021262 RGD:625566 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Hook1 hook microtubule-tethering protein 1 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787 		JBrowse link
G Hook2 hook microtubule-tethering protein 2 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181 		JBrowse link
G Hook3 hook microtubule-tethering protein 3 involved_in ISO (PMID:18799622) RGD PMID:18799622 NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338 		JBrowse link
G Kif16b kinesin family member 16B involved_in ISO (PMID:15882625) RGD PMID:15882625 NCBI chr 3:129,974,692...130,254,194
Ensembl chr 3:129,974,800...130,254,019 		JBrowse link
G Lmtk2 lemur tyrosine kinase 2 involved_in ISO (PMID:18429820) RGD PMID:18429820 NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:14617358)		 UniProt
Ensembl
RGD		 PMID:14617358 GO_REF:0000024 GO_REF:0000107 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 involved_in ISO (PMID:14617358) RGD PMID:14617358 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in ISO
IBA
IEA		 (PMID:24821423)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:24821423 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Pxk PX domain containing serine/threonine kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:16,759,857...16,828,452
Ensembl chr15:16,759,862...16,828,444 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in ISO (PMID:17562788) RGD PMID:17562788 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
ISS		 (PMID:14617358)
GO_REF:0000024
(PMID:8522602)		 RGD
UniProt		 PMID:8522602 PMID:14617358 GO_REF:0000024 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Rilp Rab interacting lysosomal protein involved_in ISO
IBA		 (PMID:17959629)
GO_REF:0000033		 RGD
GO_Central		 PMID:17959629 GO_REF:0000033 NCBI chr10:60,355,276...60,358,434
Ensembl chr10:60,355,278...60,358,781 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:17714434) RGD PMID:17714434 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Snx16 sorting nexin 16 involved_in IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:12813048)		 GO_Central
Ensembl
RGD		 PMID:12813048 PMID:12813048 GO_REF:0000033 GO_REF:0000107, RGD:737670 NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619 		JBrowse link
G Stx8 syntaxin 8 involved_in ISO
IEA		 (PMID:10564279)
GO_REF:0000107		 RGD
Ensembl		 PMID:10564279 GO_REF:0000107 NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993 		JBrowse link
G Washc1 WASH complex subunit 1 involved_in ISO (PMID:20175130) RGD PMID:20175130 NCBI chr 9:105,722,779...105,830,836
Ensembl chr 9:105,722,899...105,733,009 		JBrowse link
G Wdr81 WD repeat domain 81 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26783301), (PMID:27126989)		 UniProt
Ensembl
RGD		 PMID:26783301 PMID:27126989 GO_REF:0000024 GO_REF:0000107 NCBI chr10:60,281,969...60,295,374
Ensembl chr10:60,281,972...60,295,296 		JBrowse link
G Wdr91 WD repeat domain 91 involved_in ISO
IBA
ISS		 (PMID:26783301), (PMID:27126989)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:26783301 PMID:27126989 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:63,554,364...63,591,733
Ensembl chr 4:63,554,364...63,591,733 		JBrowse link
negative regulation of early endosome to late endosome transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx12 sorting nexin 12 involved_in ISO (PMID:22719997) RGD PMID:22719997 NCBI chr  X:66,226,995...66,356,945
Ensembl chr  X:66,227,053...66,356,950 		JBrowse link
G Snx3 sorting nexin 3 involved_in ISO (PMID:18767904) RGD PMID:18767904 NCBI chr20:45,992,446...46,025,361
Ensembl chr20:45,992,720...46,025,379 		JBrowse link
positive regulation of early endosome to late endosome transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21995445)		 Ensembl
RGD		 PMID:21995445 GO_REF:0000107 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Ezr ezrin involved_in ISO
IEA
IBA		 UniProtKB:P26038|UniProtKB:P35241 (PMID:21148287)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:21148287 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Msn moesin involved_in ISO
IEA
IBA		 UniProtKB:P15311|UniProtKB:P35241 (PMID:21148287)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:21148287 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628 		JBrowse link
G Mtmr2 myotubularin related protein 2 involved_in IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in ISO
IEA		 (PMID:21724833)
GO_REF:0000107		 RGD
Ensembl		 PMID:21724833 GO_REF:0000107 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Rab21 RAB21, member RAS oncogene family involved_in ISO (PMID:15561770) RGD PMID:15561770 NCBI chr 7:50,904,050...50,928,890
Ensembl chr 7:50,904,057...50,928,839 		JBrowse link
G Rdx radixin involved_in ISO
IBA		 UniProtKB:P15311|UniProtKB:P26038 (PMID:21148287)
GO_REF:0000033		 RGD
GO_Central		 PMID:21148287 GO_REF:0000033 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678 		JBrowse link
G Vps11 VPS11 core subunit of CORVET and HOPS complexes involved_in ISO (PMID:21148287) RGD PMID:21148287 NCBI chr 8:44,684,129...44,698,568
Ensembl chr 8:44,684,127...44,698,568 		JBrowse link
regulation of early endosome to late endosome transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Dennd10 DENN domain containing 10 involved_in ISO
IBA		 (PMID:30771381)
GO_REF:0000033		 RGD
GO_Central		 PMID:30771381 GO_REF:0000033 NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455 		JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 involved_in ISO (PMID:18256511) RGD PMID:18256511 NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317 		JBrowse link
G ENSRNOG00000067941 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr11:42,352,734...42,354,134 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in TAS
IEA		 PMID:19565474
GO_REF:0000117		 UniProt PMID:19565474 GO_REF:0000117, RGD:8553538 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 involved_in TAS
IEA		 PMID:19565474
GO_REF:0000117		 UniProt PMID:19565474 GO_REF:0000117, RGD:8553538 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in TAS
IEA		 PMID:19565474
GO_REF:0000117		 UniProt PMID:19565474 GO_REF:0000117, RGD:8553538 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in TAS
IEA		 PMID:19565474
GO_REF:0000117		 UniProt PMID:19565474 GO_REF:0000117, RGD:8553538 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 IMP RGD PMID:18768694 RGD:13504749 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:21724833) RGD PMID:21724833 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      vesicle-mediated transport 1638
        endosomal transport 294
          vesicle-mediated transport between endosomal compartments 52
            early endosome to late endosome transport 46
              negative regulation of early endosome to late endosome transport 2
              positive regulation of early endosome to late endosome transport 9
              regulation of early endosome to late endosome transport + 21
Path 2
Term Annotations click to browse term
  biological_process 20134
    localization 5690
      establishment of localization 4993
        establishment of localization in cell 2144
          intracellular transport 1404
            endosomal transport 294
              vesicle-mediated transport between endosomal compartments 52
                early endosome to late endosome transport 46
                  negative regulation of early endosome to late endosome transport 2
                  positive regulation of early endosome to late endosome transport 9
                  regulation of early endosome to late endosome transport + 21
paths to the root