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ONTOLOGY REPORT - ANNOTATIONS


Term:actin nucleation
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Accession:GO:0045010 term browser browse the term
Definition:The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
Synonyms:exact_synonym: actin filament nucleation



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actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DIAPH1 diaphanous related formin 1 acts_upstream_of_or_within ISO (MGI:4939842|PMID:21278336) MGI PMID:21278336 MGI:4939842 NCBI chr 5:136,876,396...136,980,097 JBrowse link
G DIAPH3 diaphanous related formin 3 acts_upstream_of_or_within ISO (MGI:4939842|PMID:21278336) MGI PMID:21278336 MGI:4939842 NCBI chr13:40,846,270...41,335,920
Ensembl chr13:59,676,307...60,056,672
JBrowse link
G FMN1 formin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:11,271,794...11,698,539
Ensembl chr15:30,114,113...30,495,909
JBrowse link
G INF2 inverted formin 2 acts_upstream_of_or_within ISO (MGI:4939842|PMID:21278336) MGI PMID:21278336 MGI:4939842 NCBI chr14:85,339,478...85,366,336
Ensembl chr14:105,145,779...105,163,154
JBrowse link
G LMOD1 leiomodin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:177,493,627...177,543,853
Ensembl chr 1:181,798,304...181,845,295
JBrowse link
G LMOD2 leiomodin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:115,649,102...115,657,174
Ensembl chr 7:128,331,803...128,340,263
JBrowse link
G LMOD3 leiomodin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:69,042,870...69,058,704
Ensembl chr 3:70,410,288...70,424,702
JBrowse link
G SPIRE1 spire type actin nucleation factor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr18:1,663,614...1,881,357
Ensembl chr18:16,800,870...16,992,959
JBrowse link
G SPIRE2 spire type actin nucleation factor 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:70,580,030...70,634,143
Ensembl chr16:90,273,160...90,299,061
JBrowse link
'de novo' actin filament nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRID2IP Grid2 interacting protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:6,892,842...6,956,615
Ensembl chr 7:6,690,498...6,744,194
JBrowse link
G JMY junction mediating and regulatory protein, p53 cofactor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:35,981,666...36,076,428
Ensembl chr 5:36,261,971...36,567,349
JBrowse link
Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr2A:65,289,675...65,333,219 JBrowse link
G ACTR3 actin related protein 3 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729
JBrowse link
G ACTR3B actin related protein 3B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:144,340,531...144,436,456 JBrowse link
G ARPC1A actin related protein 2/3 complex subunit 1A involved_in IEA InterPro
TreeGrafter
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 7:91,299,559...91,339,729
Ensembl chr 7:104,801,399...104,841,590
JBrowse link
G ARPC1B actin related protein 2/3 complex subunit 1B involved_in IEA Ensembl
TreeGrafter
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:91,348,120...91,368,299
Ensembl chr 7:104,861,582...104,870,369
JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 involved_in IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643
JBrowse link
G ARPC3 actin related protein 2/3 complex subunit 3 involved_in IEA InterPro
TreeGrafter
UniProt
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr12:108,007,884...108,023,386
Ensembl chr12:111,399,433...111,415,156
JBrowse link
G ARPC4 actin related protein 2/3 complex subunit 4 involved_in IEA UniProt
TreeGrafter
Ensembl
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:9,744,055...9,758,627
Ensembl chr 3:9,981,934...9,996,250
JBrowse link
G ARPC5 actin related protein 2/3 complex subunit 5 involved_in IEA Ensembl
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:159,156,229...159,165,898
Ensembl chr 1:163,311,111...163,323,554
JBrowse link
G ARPC5L actin related protein 2/3 complex subunit 5 like involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr 9:95,989,650...95,998,340
Ensembl chr 9:124,505,769...124,515,396
JBrowse link
G IQGAP2 IQ motif containing GTPase activating protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:38,593,574...38,900,327
Ensembl chr 5:39,138,359...39,516,596
JBrowse link
G JMY junction mediating and regulatory protein, p53 cofactor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:35,981,666...36,076,428
Ensembl chr 5:36,261,971...36,567,349
JBrowse link
G LOC100987084 actin-related protein 2-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:19,691,507...19,693,295 JBrowse link
G MAGEL2 MAGE family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:6,017,523...6,021,849
Ensembl chr15:21,134,857...21,138,576
JBrowse link
G TRIM27 tripartite motif containing 27 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,722,505...28,743,484
Ensembl chr 6:29,390,423...29,411,308
JBrowse link
G WHAMM WASP homolog associated with actin, golgi membranes and microtubules involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:62,763,534...62,788,639
Ensembl chr15:80,706,760...80,730,006
JBrowse link
G WIPF3 WAS/WASL interacting protein family member 3 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr 7:30,436,514...30,547,147
Ensembl chr 7:30,582,399...30,661,986
JBrowse link
negative regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3S2 adaptor related protein complex 3 subunit sigma 2 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr15:68,524,982...68,583,917 JBrowse link
G ARPIN actin related protein 2/3 complex inhibitor involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118
G CORO1A coronin 1A involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,550,383...30,556,196 JBrowse link
negative regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CORO1B coronin 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:62,796,461...62,802,204
Ensembl chr11:66,108,924...66,113,175
JBrowse link
G CTNNA2 catenin alpha 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:79,594,694...80,745,885
Ensembl chr2A:81,303,559...82,307,258
JBrowse link
G DNAI3 dynein axonemal intermediate chain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,617,609...117,690,284
Ensembl chr 1:86,474,457...86,547,080
JBrowse link
G GMFB glia maturation factor beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:35,061,469...35,076,234
Ensembl chr14:53,343,142...53,348,840
JBrowse link
G GMFG glia maturation factor gamma acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5505367|PMID:23727094) MGI
TreeGrafter
Ensembl
PMID:23727094 GO_REF:0000107 GO_REF:0000118 MGI:5505367 NCBI chr19:36,426,652...36,440,031
Ensembl chr19:44,974,435...44,982,209
JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:120,438,841...120,467,489
Ensembl chr12:124,685,091...124,700,726
JBrowse link
G POLR2F RNA polymerase II, I and III subunit F involved_in ISO PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469
JBrowse link
positive regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMN1 formin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3027450|PMID:14647292) MGI
Ensembl
PMID:14647292 GO_REF:0000107 MGI:3027450 NCBI chr15:11,271,794...11,698,539
Ensembl chr15:30,114,113...30,495,909
JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
JBrowse link
G MAGEL2 MAGE family member L2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5603599|PMID:23452853) MGI
Ensembl
PMID:23452853 GO_REF:0000107 MGI:5603599 NCBI chr15:6,017,523...6,021,849
Ensembl chr15:21,134,857...21,138,576
JBrowse link
G SCIN scinderin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:13,269,361...13,351,854
Ensembl chr 7:12,613,996...12,696,244
JBrowse link
G TRIM27 tripartite motif containing 27 acts_upstream_of_or_within ISO (MGI:5603599|PMID:23452853) MGI PMID:23452853 MGI:5603599 NCBI chr 6:28,722,505...28,743,484
Ensembl chr 6:29,390,423...29,411,308
JBrowse link
G WHAMM WASP homolog associated with actin, golgi membranes and microtubules involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:62,763,534...62,788,639
Ensembl chr15:80,706,760...80,730,006
JBrowse link
positive regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI2 abl interactor 2 involved_in ISO (PMID:21107423) UniProt PMID:21107423 NCBI chr2B:90,561,708...90,663,072
Ensembl chr2B:208,702,092...208,797,499
JBrowse link
G BRK1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:10,051,054...10,062,364
Ensembl chr 3:10,403,896...10,415,545
JBrowse link
G CYFIP1 cytoplasmic FMR1 interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr15:20,462,811...20,573,684 JBrowse link
G FCHSD2 FCH and double SH3 domains 2 involved_in ISO (PMID:29887380) UniProt PMID:29887380 NCBI chr11:67,915,796...68,219,482 JBrowse link
G NCKAP1 NCK associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:70,193,950...70,308,442
Ensembl chr2B:188,003,235...188,116,710
JBrowse link
G WASF1 WASP family member 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 6:107,911,751...107,988,821
Ensembl chr 6:111,951,726...111,979,329
JBrowse link
G WASF2 WASP family member 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:26,665,853...26,750,618
Ensembl chr 1:27,717,538...27,737,316
JBrowse link
G WASF3 WASP family member 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:7,849,687...7,980,979
Ensembl chr13:26,250,171...26,328,553
JBrowse link
regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VIL1 villin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:105,677,371...105,711,293
Ensembl chr2B:224,274,548...224,304,550
JBrowse link
G WASHC5 WASH complex subunit 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5883184|PMID:27390154) Ensembl
TreeGrafter
MGI
PMID:27390154 GO_REF:0000107 GO_REF:0000118 MGI:5883184 NCBI chr 8:121,710,118...121,777,977
Ensembl chr 8:124,461,424...124,529,262
JBrowse link
regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1AR adaptor related protein complex 1 associated regulatory protein acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5429457|PMID:22689987) MGI
Ensembl
InterPro
PMID:22689987 GO_REF:0000002 GO_REF:0000107 MGI:5429457 NCBI chr 4:104,720,583...104,762,097
Ensembl chr 4:115,282,727...115,322,872
JBrowse link
G ARF1 ADP ribosylation factor 1 involved_in ISO PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr 1:203,484,803...203,501,395
Ensembl chr 1:208,695,615...208,712,105
JBrowse link
G ARFIP1 ADP ribosylation factor interacting protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:145,119,881...145,252,601
Ensembl chr 4:156,770,510...156,901,754
JBrowse link
G ARFIP2 ADP ribosylation factor interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:6,608,393...6,613,245
Ensembl chr11:6,290,034...6,296,817
JBrowse link
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:25,114,221...25,454,984
Ensembl chr 6:25,441,682...25,780,092
JBrowse link
G CARMIL2 capping protein regulator and myosin 1 linker 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:47,989,040...48,001,455
Ensembl chr16:67,378,353...67,390,709
JBrowse link
G CARMIL3 capping protein regulator and myosin 1 linker 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:4,830,041...4,847,897
Ensembl chr14:22,954,274...22,971,981
JBrowse link
G PICK1 protein interacting with PRKCA 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr22:36,796,015...36,814,469 JBrowse link
G PPP1R37 protein phosphatase 1 regulatory subunit 37 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:42,041,222...42,094,509
Ensembl chr19:50,644,862...50,697,953
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16309
    cellular process 15385
      actin filament-based process 817
        actin cytoskeleton organization 728
          actin filament organization 466
            actin nucleation 58
              'de novo' actin filament nucleation 2
              Arp2/3 complex-mediated actin nucleation + 41
              negative regulation of actin nucleation + 10
              positive regulation of actin nucleation + 14
              regulation of actin nucleation + 35
Path 2
Term Annotations click to browse term
  biological_process 16309
    cellular process 15385
      cellular component organization or biogenesis 6566
        cellular component organization 6345
          organelle organization 3583
            cytoskeleton organization 1501
              actin cytoskeleton organization 728
                actin filament organization 466
                  actin nucleation 58
                    'de novo' actin filament nucleation 2
                    Arp2/3 complex-mediated actin nucleation + 41
                    negative regulation of actin nucleation + 10
                    positive regulation of actin nucleation + 14
                    regulation of actin nucleation + 35
paths to the root