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ONTOLOGY REPORT - ANNOTATIONS


Term:actin nucleation
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Accession:GO:0045010 term browser browse the term
Definition:The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
Synonyms:exact_synonym: actin filament nucleation



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actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evl Enah/Vasp-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:127,473,119...127,594,342
Ensembl chr 6:127,474,543...127,594,344
JBrowse link
G Fmn1 formin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Gsn gelsolin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Lmod1 leiomodin 1 involved_in ISO
ISS
(PMID:26370058)
GO_REF:0000024
RGD
UniProt
PMID:26370058 GO_REF:0000024 NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900
JBrowse link
G Lmod2 leiomodin 2 involved_in ISO
ISS
(PMID:20685966), (PMID:25250574), (PMID:26370058)
GO_REF:0000024
RGD
UniProt
PMID:20685966 PMID:25250574 PMID:26370058 GO_REF:0000024 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
JBrowse link
G Lmod3 leiomodin 3 involved_in ISO (PMID:25250574) RGD PMID:25250574 NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244
JBrowse link
G Spire1 spire-type actin nucleation factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:61,041,290...61,171,670
Ensembl chr18:61,041,290...61,171,899
JBrowse link
G Spire2 spire-type actin nucleation factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:51,373,368...51,411,920
Ensembl chr19:51,373,228...51,411,920
JBrowse link
G Vil1 villin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
JBrowse link
'de novo' actin filament nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in IBA
ISO
PMID:21873635
(MGI:4418600|PMID:19287377)
RGD PMID:19287377 PMID:21873635 MGI:4418600, RGD:13792537 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006
JBrowse link
Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:11741539), (PMID:17220302), (PMID:29925947)
PMID:21873635
UniProt
RGD
PMID:11741539 PMID:17220302 PMID:29925947 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
JBrowse link
G Actr3 actin related protein 3 involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(PMID:11741539), (PMID:17220302)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11741539 PMID:17220302 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A involved_in IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B involved_in IBA
ISO
PMID:21873635
(PMID:11741539)
RGD PMID:11741539 PMID:21873635 RGD:13792537 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000002
(PMID:11741539)
Ensembl
InterPro
RGD
PMID:11741539 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:13792537 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 involved_in ISO
IBA
(PMID:11741539)
PMID:21873635
RGD PMID:11741539 PMID:21873635 RGD:13792537 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 involved_in ISO (PMID:11741539) RGD PMID:11741539 NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000002
(PMID:11741539)
InterPro
RGD
PMID:11741539 PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410
JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
JBrowse link
G Arpc5l-ps1 actin related protein 2/3 complex, subunit 5-like, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:45,263,352...45,264,349 JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 involved_in ISO (PMID:12515716) RGD PMID:12515716 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in IBA
ISO
PMID:21873635
(MGI:4418600|PMID:19287377)
RGD PMID:19287377 PMID:21873635 MGI:4418600, RGD:13792537 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006
JBrowse link
G Magel2 MAGE family member L2 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr 1:115,880,137...115,884,680
Ensembl chr 1:115,880,474...115,884,250
JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643
JBrowse link
G Washc1 WASH complex subunit 1 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
(MGI:5603599|PMID:23452853)
(MGI:4415646|PMID:19922875)
GO_REF:0000107
(PMID:23452853)
UniProt
RGD
Ensembl
PMID:19922875 PMID:23452853 GO_REF:0000024 GO_REF:0000107 MGI:4415646 MGI:5603599 NCBI chr 9:105,722,779...105,830,836
Ensembl chr 9:105,722,899...105,733,009
JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:135,526,363...135,557,091
Ensembl chr 1:135,526,386...135,554,759
JBrowse link
negative regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpin actin-related protein 2/3 complex inhibitor involved_in ISO
IBA
(PMID:24132237)
PMID:21873635
RGD PMID:24132237 PMID:21873635 RGD:13792537 NCBI chr 1:133,864,288...133,873,124
Ensembl chr 1:133,864,265...133,873,124
JBrowse link
G Coro1a coronin 1A involved_in ISO (PMID:17442961) RGD PMID:17442961 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
JBrowse link
negative regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1b coronin 1B involved_in IEA
ISO
GO_REF:0000107
(PMID:17350576), (PMID:18775315)
Ensembl
RGD
PMID:17350576 PMID:18775315 GO_REF:0000107 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
JBrowse link
G Ctnna2 catenin alpha 2 involved_in ISO (PMID:30013181) RGD PMID:30013181 NCBI chr 4:109,293,978...110,443,413
Ensembl chr 4:109,293,978...110,443,522
JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 involved_in ISO (PMID:32128961) RGD PMID:32128961 NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
JBrowse link
G Gmfb glia maturation factor, beta involved_in IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gmfg glia maturation factor, gamma involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(MGI:5505367|PMID:23727094)
PMID:21873635
Ensembl
RGD
PMID:23727094 PMID:21873635 GO_REF:0000107 MGI:5505367, RGD:13792537 NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (MGI:5805366|PMID:17318189) RGD PMID:17318189 MGI:5805366 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734
JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
positive regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmn1 formin 1 acts_upstream_of_or_within ISO (MGI:3027450|PMID:14647292) RGD PMID:14647292 MGI:3027450 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Gsn gelsolin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Magel2 MAGE family member L2 acts_upstream_of_or_within ISO MGI:1916017 (MGI:5603599|PMID:23452853) RGD PMID:23452853 MGI:5603599 NCBI chr 1:115,880,137...115,884,680
Ensembl chr 1:115,880,474...115,884,250
JBrowse link
G Scin scinderin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 6:57,110,128...57,188,059
Ensembl chr 6:57,109,403...57,188,242
JBrowse link
G Trim27 tripartite motif-containing 27 acts_upstream_of_or_within ISO MGI:1916017 (MGI:5603599|PMID:23452853) RGD PMID:23452853 MGI:5603599 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643
JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in ISO (PMID:18614018) RGD PMID:18614018 NCBI chr 1:135,526,363...135,557,091
Ensembl chr 1:135,526,386...135,554,759
JBrowse link
positive regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 9:61,856,379...61,904,029
Ensembl chr 9:61,827,139...61,905,699
JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 4:146,750,821...146,766,050
Ensembl chr 4:146,750,821...146,768,856
JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 involved_in ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:155,444,471...155,685,539
Ensembl chr 1:155,444,460...155,685,539
JBrowse link
G Nckap1 NCK-associated protein 1 involved_in ISO
IEA
(PMID:21107423)
GO_REF:0000107
RGD
Ensembl
PMID:21107423 GO_REF:0000107 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
JBrowse link
G RGD1561552 similar to WASP family 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:73,040,984...73,043,716
Ensembl chr  X:73,040,902...73,043,716
JBrowse link
G Was WASP actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:14,405,096...14,413,850
Ensembl chr  X:14,405,124...14,413,849
JBrowse link
G Wasf1 WASP family member 1 involved_in ISO
IBA
(PMID:21107423)
PMID:21873635
RGD PMID:21107423 PMID:21873635 RGD:13792537 NCBI chr20:44,325,815...44,372,999
Ensembl chr20:44,325,795...44,372,996
JBrowse link
G Wasf2 WASP family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,336,816...145,402,041
Ensembl chr 5:145,336,842...145,399,242
JBrowse link
G Wasf3 WASP family member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751
JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vil1 villin 1 involved_in ISO (PMID:16921170), (PMID:17182858), (PMID:19808673) RGD PMID:16921170 PMID:17182858 PMID:19808673 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
JBrowse link
G Washc5 WASH complex subunit 5 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3573938|MGI:5910638 (MGI:5883184|PMID:27390154)
RGD PMID:27390154 PMID:21873635 MGI:5883184, RGD:13792537 NCBI chr 7:90,884,333...90,936,118
Ensembl chr 7:90,884,197...90,936,103
JBrowse link
regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1ar adaptor-related protein complex 1 associated regulatory protein acts_upstream_of_or_within ISO MGI:1923959 (MGI:5429457|PMID:22689987) RGD PMID:22689987 MGI:5429457 NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013
JBrowse link
G Arf1 ADP-ribosylation factor 1 involved_in IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336
JBrowse link
G Coro1b coronin 1B involved_in IC PMID:22619279 UniProt PMID:22619279 RGD:10047170 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      actin filament-based process 833
        actin cytoskeleton organization 746
          actin filament organization 467
            actin nucleation 51
              'de novo' actin filament nucleation 1
              Arp2/3 complex-mediated actin nucleation + 38
              negative regulation of actin nucleation + 9
              positive regulation of actin nucleation + 17
              regulation of actin nucleation + 32
Path 2
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      cellular component organization or biogenesis 6483
        cellular component organization 6237
          organelle organization 3753
            cytoskeleton organization 1453
              actin cytoskeleton organization 746
                actin filament organization 467
                  actin nucleation 51
                    'de novo' actin filament nucleation 1
                    Arp2/3 complex-mediated actin nucleation + 38
                    negative regulation of actin nucleation + 9
                    positive regulation of actin nucleation + 17
                    regulation of actin nucleation + 32
paths to the root