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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-templated DNA replication maintenance of fidelity
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Accession:GO:0045005 term browser browse the term
Definition:A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
Synonyms:exact_synonym: DNA-dependent DNA replication maintenance of fidelity;   maintenance of fidelity involved in DNA-dependent DNA replication
 related_synonym: maintenance of fidelity during DNA-dependent DNA replication

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DNA replication proofreading term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12429860) Ensembl
MGI
TreeGrafter		 PMID:12429860 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936889:231,373...250,985
Ensembl chrNW_004936889:231,373...250,987
Ensembl chrNW_004936889:231,373...250,987 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936660:2,575,255...2,622,867
Ensembl chrNW_004936660:2,575,360...2,622,852 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:15,178,947...15,196,277
Ensembl chrNW_004936483:15,179,342...15,195,258 		JBrowse link
DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936674:466,495...528,072
Ensembl chrNW_004936674:466,456...530,317 		JBrowse link
G Nbn nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936544:3,773,828...3,812,673
Ensembl chrNW_004936544:3,775,220...3,808,837 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936647:2,546,100...2,637,524
Ensembl chrNW_004936647:2,543,599...2,637,846 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:2,482,915...2,554,077 JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:4,180,607...4,238,623
Ensembl chrNW_004936561:4,180,546...4,229,036 		JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO (PMID:26300262)
(MGI:5705200|PMID:26300262)		 UniProt PMID:26300262 MGI:5705200 NCBI chrNW_004936658:1,657,226...1,734,150 JBrowse link
mitotic recombination-dependent replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2 DNA repair associated involved_in ISO (PMID:21076401) BHF-UCL PMID:21076401 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
negative regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dynll1 dynein light chain LC8-type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:451,846...484,841
Ensembl chrNW_004936668:448,489...500,800 		JBrowse link
regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Znf365 zinc finger protein 365 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936614:833,665...853,547
Ensembl chrNW_004936614:835,866...853,547 		JBrowse link
replication fork arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Timeless timeless circadian regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:780,021...792,856
Ensembl chrNW_004936646:780,087...792,837 		JBrowse link
G Tipin TIMELESS interacting protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:26,516,511...26,531,403
Ensembl chrNW_004936471:26,517,042...26,531,410 		JBrowse link
replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asf1a anti-silencing function 1A histone chaperone involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936658:1,699,150...1,713,079
Ensembl chrNW_004936658:1,699,044...1,715,582 		JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (MGI:6467697|PMID:29125140) UniProt PMID:29125140 MGI:6467697 NCBI chrNW_004936540:4,074,543...4,178,859
Ensembl chrNW_004936540:4,074,570...4,178,898 		JBrowse link
G Atrx ATRX chromatin remodeler involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936683:2,496,307...2,718,539
Ensembl chrNW_004936683:2,495,959...2,718,620 		JBrowse link
G Blm BLM RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:16,194,092...16,295,803
Ensembl chrNW_004936483:16,194,092...16,255,905 		JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936609:2,034,271...2,096,274 JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:13,927,605...13,975,722
Ensembl chrNW_004936477:13,930,161...13,974,589 		JBrowse link
G Brca2 BRCA2 DNA repair associated acts_upstream_of_or_within ISO (PMID:14681210) MGI PMID:14681210 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Cdk9 cyclin dependent kinase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:15,446,864...15,450,750
Ensembl chrNW_004936487:15,446,858...15,452,796 		JBrowse link
G Cenpx centromere protein X involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936594:5,517,665...5,520,606
Ensembl chrNW_004936594:5,516,915...5,520,553 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:181,457...209,286
Ensembl chrNW_004936606:186,223...208,499 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:8,712,168...8,720,728
Ensembl chrNW_004936500:8,712,205...8,739,953 		JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:11,307,739...11,316,203
Ensembl chrNW_004936490:11,308,393...11,314,785 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936694:2,217,352...2,220,556
Ensembl chrNW_004936694:2,217,811...2,220,432 		JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936491:11,962,161...11,975,164
Ensembl chrNW_004936491:11,962,087...11,979,349 		JBrowse link
G Exd2 exonuclease 3'-5' domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:12,432,752...12,479,807
Ensembl chrNW_004936495:12,432,731...12,479,876 		JBrowse link
G Fam111a FAM111 trypsin like peptidase A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:3,482,649...3,488,331
Ensembl chrNW_004936581:3,480,412...3,490,195 		JBrowse link
G Fancm FA complementation group M involved_in ISO (PMID:20347428) UniProt PMID:20347428 NCBI chrNW_004936583:4,085,802...4,145,621 JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936484:8,635,752...8,689,949
Ensembl chrNW_004936484:8,635,753...8,689,971 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:13,157,114...13,182,797
Ensembl chrNW_004936493:13,157,119...13,177,525 		JBrowse link
G LOC101959362 peroxisomal membrane protein PEX14 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936623:4,313,186...4,462,462
Ensembl chrNW_004936623:4,313,147...4,462,528
Ensembl chrNW_004936623:4,313,147...4,462,528 		JBrowse link
G LOC101962206 histone-lysine N-methyltransferase SETMAR involved_in ISO (PMID:20457750), (PMID:22231448), (PMID:24573677) UniProt PMID:20457750 PMID:22231448 PMID:24573677 NCBI chrNW_004936577:3,761,078...3,771,864 JBrowse link
G Mms22l MMS22 like, DNA repair protein involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936699:486,510...608,532
Ensembl chrNW_004936699:486,491...608,562 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:3,670,759...3,677,375
Ensembl chrNW_004936599:3,670,862...3,677,239 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin dependent kinase substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:6,713,065...6,728,011
Ensembl chrNW_004936557:6,713,095...6,722,808 		JBrowse link
G Ooep oocyte expressed protein involved_in ISO (MGI:6467697|PMID:29125140) UniProt PMID:29125140 MGI:6467697 NCBI chrNW_004937318:2,623...3,622 JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO (MGI:5522574|PMID:24115439) BHF-UCL PMID:24115439 MGI:5522574 NCBI chrNW_004936485:13,766,221...13,771,215 JBrowse link
G Polq DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:7,904,166...8,004,305
Ensembl chrNW_004936536:7,904,981...8,004,199 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936554:4,536,246...4,571,000
Ensembl chrNW_004936554:4,534,970...4,569,549 		JBrowse link
G Rad51 RAD51 recombinase involved_in
acts_upstream_of_or_within		 ISO (PMID:22778135)
(PMID:18417535), (PMID:25585578)		 BHF-UCL
MGI
UniProt		 PMID:18417535 PMID:22778135 PMID:25585578 NCBI chrNW_004936471:4,119,020...4,136,811
Ensembl chrNW_004936471:4,114,530...4,136,248 		JBrowse link
G Recql RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936548:5,349,878...5,384,603
Ensembl chrNW_004936548:5,362,517...5,384,338 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:23,544,974...23,586,716
Ensembl chrNW_004936475:23,544,953...23,586,740 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:10,920,979...10,954,483
Ensembl chrNW_004936514:10,922,322...10,954,402 		JBrowse link
G Smarcal1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936586:828,661...887,988
Ensembl chrNW_004936586:828,650...888,047 		JBrowse link
G Tipin TIMELESS interacting protein involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chrNW_004936471:26,516,511...26,531,403
Ensembl chrNW_004936471:26,517,042...26,531,410 		JBrowse link
G Tonsl tonsoku like, DNA repair protein involved_in ISO (PMID:21055983), (PMID:21055984), (PMID:21055985)
(PMID:27338793), (PMID:29478807)		 UniProt PMID:21055983 PMID:21055984 PMID:21055985 PMID:27338793 PMID:29478807 NCBI chrNW_004936470:7,817,444...7,829,124 JBrowse link
G Traip TRAF interacting protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936529:1,434,629...1,466,382 JBrowse link
G Wrn WRN RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936792:862,659...1,005,065
Ensembl chrNW_004936792:862,383...1,005,755 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936469:40,328,850...40,558,797
Ensembl chrNW_004936469:40,328,787...40,609,533 		JBrowse link
replication fork reversal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator associated arginine methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:1,071,883...1,120,917
Ensembl chrNW_004936659:1,090,164...1,123,920 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936521:9,843,867...9,884,248
Ensembl chrNW_004936521:9,843,900...9,883,932 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:40,328,850...40,558,797
Ensembl chrNW_004936469:40,328,787...40,609,533 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      organic substance metabolic process 9091
        macromolecule metabolic process 7563
          nucleic acid metabolic process 4163
            DNA metabolic process 874
              DNA-templated DNA replication maintenance of fidelity 53
                DNA replication proofreading 3
                cell cycle DNA replication maintenance of fidelity + 1
                mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                replication fork arrest + 2
                replication fork processing + 48
Path 2
Term Annotations click to browse term
  biological_process 15871
    metabolic process 9527
      cellular metabolic process 8291
        heterocycle metabolic process 4795
          nucleobase-containing compound metabolic process 4641
            nucleic acid metabolic process 4163
              DNA metabolic process 874
                DNA replication 255
                  DNA-templated DNA replication 148
                    DNA-templated DNA replication maintenance of fidelity 53
                      DNA replication proofreading 3
                      cell cycle DNA replication maintenance of fidelity + 1
                      mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                      replication fork arrest + 2
                      replication fork processing + 48
paths to the root