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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-templated DNA replication maintenance of fidelity
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Accession:GO:0045005 term browser browse the term
Definition:A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
Synonyms:exact_synonym: DNA-dependent DNA replication maintenance of fidelity;   maintenance of fidelity involved in DNA-dependent DNA replication
 related_synonym: maintenance of fidelity during DNA-dependent DNA replication


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DNA replication proofreading term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 PMID:21873635
MGI:2447628 (MGI:2445645|PMID:12429860)
GO_REF:0000107		 RGD
Ensembl		 PMID:12429860 PMID:21873635 GO_REF:0000107 MGI:2445645, RGD:13792537 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29670289)		 UniProt
Ensembl
RGD		 PMID:29670289 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (PMID:28834754), (PMID:29670289) RGD PMID:28834754 PMID:29670289 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO
IEA		 (PMID:26300262)
GO_REF:0000107
(MGI:5705200|PMID:26300262)		 RGD
Ensembl		 PMID:26300262 GO_REF:0000107 MGI:5705200 NCBI chr20:32,818,219...32,929,577
Ensembl chr20:32,844,951...32,929,600 		JBrowse link
mitotic recombination-dependent replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated involved_in IEA
ISO		 GO_REF:0000107
(PMID:21076401)		 Ensembl
RGD		 PMID:21076401 GO_REF:0000107 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Rad51 RAD51 recombinase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp365 zinc finger protein 365 involved_in ISS
IEA
IBA		 GO_REF:0000024
GO_REF:0000107
PMID:21873635		 UniProt
Ensembl		 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr20:20,666,240...20,689,734
Ensembl chr20:20,666,240...20,691,238 		JBrowse link
replication fork arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC120094818 TIMELESS-interacting protein-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,693,252...113,694,434
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Slfn13 schlafen family member 13 involved_in ISO (PMID:29395061) RGD PMID:29395061 NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383 		JBrowse link
G Timeless timeless circadian regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738 		JBrowse link
G Tipin timeless interacting protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,542,841...113,544,022
Ensembl chr 9:113,543,173...113,605,998 		JBrowse link
replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alyref Aly/REF export factor involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone involved_in ISO (PMID:29478807) RGD PMID:29478807 NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808 		JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (MGI:6467697|PMID:29125140) RGD PMID:29125140 MGI:6467697 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Atrx ATRX, chromatin remodeler involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5568153|PMID:24651726)		 UniProt
Ensembl
RGD		 PMID:24651726 GO_REF:0000024 GO_REF:0000107 MGI:5568153 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:17115688)
(MGI:6467697|PMID:29125140)		 RGD PMID:17115688 PMID:29125140 MGI:6467697 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 involved_in ISO
IBA		 (PMID:26166705)
PMID:21873635		 RGD PMID:26166705 PMID:21873635 RGD:13792537 NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490 		JBrowse link
G Brca2 BRCA2, DNA repair associated acts_upstream_of_or_within ISO MGI:1930616 (MGI:2683861|PMID:14681210) RGD PMID:14681210 MGI:2683861 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 involved_in ISO
IEA		 (PMID:20930849)
GO_REF:0000107		 RGD
Ensembl		 PMID:20930849 GO_REF:0000107 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Cenps centromere protein S involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cenpx centromere protein X involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr10:105,991,469...105,994,310 JBrowse link
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 involved_in ISO (PMID:26503245) RGD PMID:26503245 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,919,834...30,933,150
Ensembl chr11:30,923,239...30,932,889 		JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in ISO
IBA		 (PMID:18413719)
PMID:21873635		 RGD PMID:18413719 PMID:21873635 RGD:13792537 NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in ISO
IBA		 (PMID:17289582)
PMID:21873635		 RGD PMID:17289582 PMID:21873635 RGD:13792537 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in IBA
ISO		 PMID:21873635
(PMID:27723717), (PMID:27723720)		 RGD PMID:27723717 PMID:27723720 PMID:21873635 RGD:13792537 NCBI chr14:92,298,461...92,314,044
Ensembl chr14:92,299,553...92,314,104 		JBrowse link
G Exd2 exonuclease 3'-5' domain containing 2 involved_in ISO (PMID:31255466) RGD PMID:31255466 NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442 		JBrowse link
G Fam111a FAM111 trypsin like peptidase A involved_in ISO (PMID:32165630) RGD PMID:32165630 NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547 		JBrowse link
G Fancm FA complementation group M involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028 		JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO
IBA		 (PMID:25585578)
(MGI:5566975|PMID:24108124)
PMID:21873635		 RGD PMID:24108124 PMID:25585578 PMID:21873635 MGI:5566975, RGD:13792537 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:26578604) RGD PMID:26578604 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member involved_in ISS
ISO		 GO_REF:0000024
(MGI:6467697|PMID:29125140)		 UniProt
RGD		 PMID:29125140 GO_REF:0000024 MGI:6467697 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G LOC120094818 TIMELESS-interacting protein-like involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 9:113,693,252...113,694,434
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Mms22l MMS22-like, DNA repair protein involved_in IBA
ISO		 PMID:21873635
(PMID:21055983), (PMID:21055984), (PMID:21055985), (PMID:21113133), (PMID:27797818)		 RGD PMID:21055983 PMID:21055984 PMID:21055985 PMID:21113133 PMID:27797818 More... RGD:13792537 NCBI chr 5:38,197,707...38,313,745
Ensembl chr 5:38,197,779...38,313,745 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in ISO
IEA		 (PMID:17289582), (PMID:18413719)
GO_REF:0000107		 RGD
Ensembl		 PMID:17289582 PMID:18413719 GO_REF:0000107 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 involved_in ISO (PMID:26323318) RGD PMID:26323318 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229 		JBrowse link
G Ooep oocyte expressed protein involved_in ISO (MGI:6467697|PMID:29125140) RGD PMID:29125140 MGI:6467697 NCBI chr 8:79,223,388...79,224,554
Ensembl chr 8:79,223,375...79,224,541 		JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO UniProtKB:Q0VGM9 (MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:5522574 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Polq DNA polymerase theta involved_in IEA
ISO		 GO_REF:0000107
(PMID:30655289)		 Ensembl
RGD		 PMID:30655289 GO_REF:0000107 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in IBA
ISO		 PMID:21873635
(PMID:24240614), (PMID:24267451), (PMID:28534480)		 RGD PMID:24240614 PMID:24267451 PMID:28534480 PMID:21873635 RGD:13792537 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Rad51 RAD51 recombinase acts_upstream_of_or_within
involved_in		 ISO MGI:5444025 (MGI:5442243|PMID:22778135)
(PMID:18417535), (PMID:22778135), (PMID:25585578)		 RGD PMID:18417535 PMID:22778135 PMID:25585578 MGI:5442243 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:26474068) RGD PMID:26474068 NCBI chr19:39,235,883...39,268,479
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:5522574 NCBI chr 3:168,427,247...168,465,349
Ensembl chr 3:168,419,579...168,465,348 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:20457750), (PMID:22231448), (PMID:24573677) RGD PMID:20457750 PMID:22231448 PMID:24573677 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:19793862)		 UniProt
RGD		 PMID:19793862 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 9:74,239,718...74,286,156
Ensembl chr 9:74,240,241...74,286,146 		JBrowse link
G Thoc1 THO complex subunit 1 involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr18:983,824...1,019,123
Ensembl chr18:983,824...1,019,114 		JBrowse link
G Tipin timeless interacting protein involved_in IEA GO_REF:0000002
GO_REF:0000104		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 9:113,542,841...113,544,022
Ensembl chr 9:113,543,173...113,605,998 		JBrowse link
G Tonsl tonsoku-like, DNA repair protein involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:21055983), (PMID:21055984), (PMID:21055985), (PMID:27338793), (PMID:29478807)
PMID:21873635		 UniProt
RGD		 PMID:21055983 PMID:21055984 PMID:21055985 PMID:27338793 PMID:29478807 More... GO_REF:0000024, RGD:13792537 NCBI chr 7:108,345,704...108,360,792
Ensembl chr 7:108,346,047...108,360,750 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO
IBA		 (PMID:26711499), (PMID:27462463)
PMID:21873635		 RGD PMID:26711499 PMID:27462463 PMID:21873635 RGD:13792537 NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638 		JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:12882351), (PMID:17115688) RGD PMID:12882351 PMID:17115688 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in ISO
IBA		 (PMID:22704558), (PMID:22705370)
PMID:21873635		 RGD PMID:22704558 PMID:22705370 PMID:21873635 RGD:13792537 NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670 		JBrowse link
replication fork reversal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 involved_in ISO
ISS		 (PMID:33412112)
GO_REF:0000024		 RGD
UniProt		 PMID:33412112 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:33412112)		 UniProt
RGD		 PMID:33412112 GO_REF:0000024 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in ISO (PMID:22704558) RGD PMID:22704558 NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      organic substance metabolic process 10895
        macromolecule metabolic process 9164
          nucleic acid metabolic process 4966
            DNA metabolic process 993
              DNA-templated DNA replication maintenance of fidelity 53
                DNA replication proofreading 2
                cell cycle DNA replication maintenance of fidelity + 2
                mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                replication fork arrest + 5
                replication fork processing + 48
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      cellular metabolic process 10124
        heterocycle metabolic process 5704
          nucleobase-containing compound metabolic process 5539
            nucleic acid metabolic process 4966
              DNA metabolic process 993
                DNA replication 270
                  DNA-templated DNA replication 154
                    DNA-templated DNA replication maintenance of fidelity 53
                      DNA replication proofreading 2
                      cell cycle DNA replication maintenance of fidelity + 2
                      mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                      replication fork arrest + 5
                      replication fork processing + 48
paths to the root