Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:DNA-dependent DNA replication maintenance of fidelity
go back to main search page
Accession:GO:0045005 term browser browse the term
Definition:A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
Synonyms:exact_synonym: maintenance of fidelity involved in DNA-dependent DNA replication
 related_synonym: maintenance of fidelity during DNA-dependent DNA replication


show annotations for term's descendants           Sort by:
 
DNA replication proofreading term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:2447628 (MGI:2445645|PMID:12429860)
GO_REF:0000107
RGD
Ensembl
PMID:12429860, PMID:21873635 GO_REF:0000107 MGI:2445645, RGD:13792537 NCBI chr 1:95,025,462...95,041,559 JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:46,345,420...46,393,984 JBrowse link
DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:29670289)
UniProt
Ensembl
RGD
PMID:29670289 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451 JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (PMID:28834754), (PMID:29670289) RGD PMID:28834754 PMID:29670289 NCBI chr 3:145,761,549...145,794,420 JBrowse link
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO (PMID:26300262)
(MGI:5705200|PMID:26300262)
RGD PMID:26300262 MGI:5705200 NCBI chr20:32,818,219...32,929,577 JBrowse link
mitotic recombination-dependent replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated involved_in IEA
ISO
GO_REF:0000107
(PMID:21076401)
Ensembl
RGD
PMID:21076401 GO_REF:0000107 NCBI chr12:59,492...103,789 JBrowse link
G Rad51 RAD51 recombinase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:106,099,753...106,125,038 JBrowse link
regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp365 zinc finger protein 365 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:23966166)
UniProt
RGD
PMID:23966166, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:20,666,240...20,689,734 JBrowse link
replication fork arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slfn13 schlafen family member 13 involved_in ISO (PMID:29395061) RGD PMID:29395061 NCBI chr10:67,909,105...67,955,912 JBrowse link
G Timeless timeless circadian regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:654,804...678,769 JBrowse link
G Tipin timeless interacting protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:64,780,741...64,801,355 JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,542,841...113,544,022 JBrowse link
replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07030926.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Alyref Aly/REF export factor involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr10:105,871,306...105,875,076 JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (MGI:6467697|PMID:29125140) RGD PMID:29125140 MGI:6467697 NCBI chr 8:96,426,704...96,524,152 JBrowse link
G Atrx ATRX, chromatin remodeler involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5568153|PMID:24651726)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24651726 GO_REF:0000024 GO_REF:0000107 MGI:5568153 NCBI chr  X:70,850,981...70,997,330 JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:17115688)
(MGI:6467697|PMID:29125140)
RGD PMID:17115688 PMID:29125140 MGI:6467697 NCBI chr 1:134,409,832...134,496,073 JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 involved_in ISO (PMID:26166705) RGD PMID:26166705 NCBI chr14:69,108,483...69,163,255 JBrowse link
G Cdk9 cyclin-dependent kinase 9 involved_in ISO (PMID:20930849) RGD PMID:20930849 NCBI chr 3:15,996,467...16,001,315 JBrowse link
G Cenps centromere protein S involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cenpx centromere protein X involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr10:105,991,469...105,994,411 JBrowse link
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935 JBrowse link
G Ddx11 DEAD/H-box helicase 11 involved_in ISO (PMID:26503245) RGD PMID:26503245 NCBI chr 9:105,833,234...105,862,844 JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,586,736...79,595,515 JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,913,216...13,915,991 JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in ISO
IBA
(PMID:27723717), (PMID:27723720)
PMID:21873635
RGD PMID:27723717 PMID:27723720, PMID:21873635 RGD:13792537
G Exd2 exonuclease 3'-5' domain containing 2 involved_in ISO (PMID:31255466) RGD PMID:31255466 NCBI chr 6:100,116,867...100,150,452 JBrowse link
G Fam111a FAM111 trypsin like peptidase A involved_in ISO (PMID:32165630) RGD PMID:32165630 NCBI chr 1:209,640,865...209,656,551 JBrowse link
G Fancm FA complementation group M involved_in ISO (PMID:20347428) RGD PMID:20347428 NCBI chr 6:83,126,903...83,180,455 JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO
IBA
(PMID:25585578)
(MGI:5566975|PMID:24108124)
PMID:21873635
RGD PMID:24108124 PMID:25585578, PMID:21873635 MGI:5566975, RGD:13792537 NCBI chr17:66,749,506...66,787,590 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:26578604) RGD PMID:26578604 NCBI chr 6:33,947,599...33,978,461 JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member involved_in ISS
ISO
GO_REF:0000024
(MGI:6467697|PMID:29125140)
UniProt
RGD
PMID:29125140 GO_REF:0000024 MGI:6467697 NCBI chr 8:73,842,344...73,844,248 JBrowse link
G Mms22l MMS22-like, DNA repair protein involved_in ISO
IBA
(PMID:21055983), (PMID:21055984), (PMID:21055985)
PMID:21873635
RGD PMID:21055983 PMID:21055984 PMID:21055985, PMID:21873635 RGD:13792537 NCBI chr 5:38,197,707...38,313,745 JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 involved_in ISO (PMID:26323318) RGD PMID:26323318 NCBI chr13:43,345,091...43,374,316 JBrowse link
G Ooep oocyte expressed protein involved_in ISO (MGI:6467697|PMID:29125140) RGD PMID:29125140 MGI:6467697 NCBI chr 8:79,223,388...79,224,554 JBrowse link
G Pcna proliferating cell nuclear antigen involved_in ISO UniProtKB:Q0VGM9 (MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:5522574 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Primpol primase and DNA directed polymerase involved_in IBA
ISO
PMID:21873635
(PMID:24240614), (PMID:24267451), (PMID:28534480)
RGD PMID:24240614 PMID:24267451 PMID:28534480, PMID:21873635 RGD:13792537 NCBI chr16:45,681,252...45,715,758 JBrowse link
G Rad51 RAD51 recombinase involved_in
acts_upstream_of_or_within
ISO (PMID:22778135), (PMID:25585578)
MGI:5444025 (MGI:5442243|PMID:22778135)
RGD PMID:22778135 PMID:25585578 MGI:5442243 NCBI chr 3:106,099,753...106,125,038 JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:26474068) RGD PMID:26474068 NCBI chr19:39,235,883...39,268,536 JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5522574|PMID:24115439) RGD PMID:24115439 MGI:5522574 NCBI chr 3:168,427,247...168,465,349 JBrowse link
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:20457750), (PMID:22231448), (PMID:24573677) RGD PMID:20457750 PMID:22231448 PMID:24573677 NCBI chr 4:141,046,058...141,058,183 JBrowse link
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:19793862)
UniProt
RGD
PMID:19793862, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 9:74,239,718...74,286,156 JBrowse link
G Thoc1 THO complex 1 involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr18:983,606...1,020,379 JBrowse link
G Tonsl tonsoku-like, DNA repair protein involved_in ISS
ISO
GO_REF:0000024
(PMID:21055983), (PMID:21055984), (PMID:21055985)
UniProt
RGD
PMID:21055983 PMID:21055984 PMID:21055985 GO_REF:0000024 NCBI chr 7:108,345,704...108,360,792 JBrowse link
G Traip TRAF-interacting protein involved_in ISO (PMID:26711499), (PMID:27462463) RGD PMID:26711499 PMID:27462463 NCBI chr 8:108,641,860...108,661,640 JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:12882351), (PMID:17115688) RGD PMID:12882351 PMID:17115688 NCBI chr16:58,763,517...58,898,604 JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in ISO
IBA
(PMID:22704558), (PMID:22705370)
PMID:21873635
RGD PMID:22704558 PMID:22705370, PMID:21873635 RGD:13792537 NCBI chr13:39,440,653...39,595,782 JBrowse link
replication fork protection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1930616 (MGI:2683861|PMID:14681210)
Ensembl
RGD
PMID:14681210 GO_REF:0000107 MGI:2683861 NCBI chr12:59,492...103,789 JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150 JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (MGI:5566975|PMID:24108124) RGD PMID:24108124 MGI:5566975 NCBI chr17:66,749,506...66,787,590 JBrowse link
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:74,239,718...74,286,156 JBrowse link
G Timeless timeless circadian regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:654,804...678,769 JBrowse link
G Tipin timeless interacting protein involved_in IBA
IEA
PMID:21873635
GO_REF:0000104
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 8:64,780,741...64,801,355 JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,542,841...113,544,022 JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:4950701|PMID:21191184)
PMID:21873635
UniProt
RGD
PMID:21191184, PMID:21873635 GO_REF:0000024 MGI:4950701, RGD:13792537 NCBI chr10:67,701,340...67,702,804 JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in IBA
ISO
PMID:21873635
(PMID:22704558), (PMID:22705370)
RGD PMID:22704558 PMID:22705370, PMID:21873635 RGD:13792537 NCBI chr13:39,440,653...39,595,782 JBrowse link
replication fork reversal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07013288.4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Dna2 DNA replication helicase/nuclease 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:25,661,652...25,690,598 JBrowse link
G Fancm FA complementation group M involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:83,126,903...83,180,455 JBrowse link
G Zgrf1 zinc finger, GRF-type containing 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:216,012,911...216,075,608 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10753
        cellular macromolecule metabolic process 8240
          DNA metabolic process 883
            DNA-dependent DNA replication maintenance of fidelity 51
              DNA replication proofreading 2
              cell cycle DNA replication maintenance of fidelity + 2
              mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
              replication fork arrest + 4
              replication fork processing + 42
              replication fork protection 9
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11334
        organic substance biosynthetic process 6025
          macromolecule biosynthetic process 5087
            cellular macromolecule biosynthetic process 5046
              DNA replication 254
                DNA-dependent DNA replication 152
                  DNA-dependent DNA replication maintenance of fidelity 51
                    DNA replication proofreading 2
                    cell cycle DNA replication maintenance of fidelity + 2
                    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + 1
                    replication fork arrest + 4
                    replication fork processing + 42
                    replication fork protection 9
paths to the root