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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic DNA integrity checkpoint signaling
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Accession:GO:0044774 term browser browse the term
Definition:A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.
Synonyms:exact_synonym: intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signal transduction involved in topo II checkpoint;   intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint;   intracellular signaling cascade involved in mitotic DNA integrity checkpoint;   intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling cascade involved in topo II checkpoint;   intracellular signaling chain involved in mitotic DNA integrity checkpoint;   intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling pathway involved in mitotic DNA integrity checkpoint;   mitotic DNA integrity checkpoint;   mitotic cell cycle G2/M transition decatenation checkpoint;   signal transduction involved in mitotic DNA integrity checkpoint
 narrow_synonym: intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signal transduction pathway involved in topo II checkpoint;   intracellular signal transduction pathway involved in topoisomerase II checkpoint;   intracellular signaling pathway involved in topo II checkpoint
 related_synonym: intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling pathway involved in topoisomerase II checkpoint;   signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint;   signal transduction via intracellular signaling cascade involved in topo II checkpoint
 alt_id: GO:0070683;   GO:1902403


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mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:18790802) RGD PMID:18790802 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain involved_in IBA
ISO		 PMID:21873635
(PMID:21726810)		 RGD PMID:21726810 PMID:21873635 RGD:13792537 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Pidd1 p53-induced death domain protein 1 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23235459)		 UniProt
RGD		 PMID:23235459 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:161,801,550...161,814,381
Ensembl chr 3:161,801,577...161,814,381 		JBrowse link
G Rpl26 ribosomal protein L26 involved_in ISO
IEA		 (PMID:16213212)
GO_REF:0000107
(MGI:5882892|PMID:16213212)		 RGD
Ensembl		 PMID:16213212 GO_REF:0000107 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:16213212)
MGI:108027 (MGI:3589512|PMID:16107883)		 RGD PMID:16107883 PMID:16213212 MGI:3589512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek2 checkpoint kinase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Stk33 serine/threonine kinase 33 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:163,276,176...163,458,580
Ensembl chr 1:163,276,340...163,458,627 		JBrowse link
G Zfp830 zinc finger protein 830 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3583779 (MGI:5428139|PMID:23213458)		 RGD PMID:23213458 PMID:21873635 MGI:5428139, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523 		JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cdc6 cell division cycle 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Clspn claspin involved_in ISO
IBA		 (PMID:16885022)
PMID:21873635		 RGD PMID:16885022 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO
IEA		 (PMID:10722740)
GO_REF:0000107		 RGD
Ensembl		 PMID:10722740 GO_REF:0000107 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371 		JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:4950701|PMID:21191184)
PMID:21873635		 UniProt
RGD		 PMID:21191184 PMID:21873635 GO_REF:0000024 MGI:4950701, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19412162)		 UniProt
RGD		 PMID:19412162 GO_REF:0000024 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO UniProtKB:P06400 (PMID:16286473) RGD PMID:16286473 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099 		JBrowse link
G Fbxo31 F-box protein 31 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19412162)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:19412162 GO_REF:0000002 GO_REF:0000024 NCBI chr19:49,624,818...49,656,083
Ensembl chr19:49,627,686...49,656,010 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 acts_upstream_of_or_within ISO MGI:4126459 (MGI:4366664|PMID:19744960) RGD PMID:19744960 MGI:4366664 NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (PMID:21731742) RGD PMID:21731742 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:20173098) RGD PMID:20173098 NCBI chr19:39,235,883...39,268,536
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rpa2 replication protein A2 involved_in ISO (PMID:21731742) RGD PMID:21731742 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO (PMID:18056458) RGD PMID:18056458 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog involved_in IEA
ISO		 GO_REF:0000107
(PMID:27906959)		 Ensembl
RGD		 PMID:27906959 GO_REF:0000107 NCBI chr13:92,578,843...92,595,142
Ensembl chr13:92,578,874...92,595,140 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:7958916)
(MGI:3589512|PMID:16107883)		 RGD PMID:7958916 PMID:16107883 MGI:3589512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (MGI:3818783|PMID:18045533), (MGI:5562498|PMID:23993650) RGD PMID:18045533 PMID:23993650 MGI:3818783 MGI:5562498 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil involved_in ISO (PMID:21329877) RGD PMID:21329877 NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622 		JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:19261746), (PMID:19261748), (PMID:19261749)		 UniProt
RGD		 PMID:19261746 PMID:19261748 PMID:19261749 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923 		JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19261748)		 UniProt
RGD		 PMID:19261748 GO_REF:0000024 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951 		JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:11309417) RGD PMID:11309417 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA		 (PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107		 RGD
Ensembl		 PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17525341), (PMID:19261746), (PMID:19261748)		 UniProt
RGD		 PMID:17525341 PMID:19261746 PMID:19261748 GO_REF:0000024 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080 		JBrowse link
G Brsk1 BR serine/threonine kinase 1 involved_in ISO (PMID:15150265) RGD PMID:15150265 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISS PMID:15150265 UniProt PMID:15150265 RGD:8554801 NCBI chr 1:197,035,522...197,088,624
Ensembl chr 1:197,035,633...197,088,092 		JBrowse link
G Ccng1 cyclin G1 IMP RGD PMID:9464250 RGD:2316029 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cdc14b cell division cycle 14B involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2679752|PMID:12937170)		 RGD PMID:12937170 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS		 (PMID:15790566)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15790566 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:23213251) RGD PMID:23213251 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO (PMID:20932473) RGD PMID:20932473 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Clspn claspin involved_in ISO
IBA		 (PMID:18662541)
PMID:21873635		 RGD PMID:18662541 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in ISO (PMID:17085480) RGD PMID:17085480 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Foxn3 forkhead box N3 involved_in ISO UniProtKB:P38111 (PMID:9154802) RGD PMID:9154802 NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401 		JBrowse link
G Foxo4 forkhead box O4 acts_upstream_of_or_within ISO (MGI:2183145|PMID:12048180) RGD PMID:12048180 MGI:2183145 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
ISS		 (PMID:16061642)
GO_REF:0000024		 RGD
UniProt		 PMID:16061642 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (MGI:5432078|PMID:20467439) RGD PMID:20467439 MGI:5432078 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G LOC100302465 hypothetical LOC100302465 involved_in ISO (MGI:4455105|PMID:20154723) RGD PMID:20154723 MGI:4455105 NCBI chr 1:189,059,744...189,293,353
Ensembl chr 1:189,059,746...189,293,435 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2684310 (MGI:2682526|PMID:14614141) RGD PMID:14614141 MGI:2682526 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604)
PMID:21873635		 Ensembl
RGD		 PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Mrnip MRN complex interacting protein involved_in ISO (PMID:27568553) RGD PMID:27568553 NCBI chr10:34,501,359...34,525,474
Ensembl chr10:34,501,384...34,525,469 		JBrowse link
G Nbn nibrin involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA
ISS		 PMID:21873635
MGI:2183796 (MGI:3805397|PMID:18614044)
GO_REF:0000107
GO_REF:0000024
(PMID:11438675)		 RGD
Ensembl
UniProt		 PMID:11438675 PMID:18614044 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3805397, RGD:13792537 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) RGD PMID:21741933 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:18662541)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:18662541 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Rint1 RAD50 interactor 1 involved_in ISO (PMID:11096100) RGD PMID:11096100 NCBI chr 4:11,319,416...11,355,773
Ensembl chr 4:11,320,955...11,355,736 		JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor acts_upstream_of_or_within ISO MGI:3904866 (MGI:5435138|PMID:22448250) RGD PMID:22448250 MGI:5435138 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414 		JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
IEA
ISS		 (PMID:17396146)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766 		JBrowse link
G Taok2 TAO kinase 2 involved_in ISO
IEA
ISS		 (PMID:17396146)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:17396146)		 Ensembl
UniProt
RGD		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Trim39 tripartite motif-containing 39 involved_in ISO
IEA
ISS		 (PMID:23213251)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23213251 GO_REF:0000024 GO_REF:0000107 NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117 		JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr17:9,523,793...9,592,810
Ensembl chr17:9,527,794...9,592,799 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS		 (PMID:15916964)
GO_REF:0000024		 RGD
UniProt		 PMID:15916964 GO_REF:0000024 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in ISO (PMID:11298456) RGD PMID:11298456 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,586,736...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)
PMID:21873635		 Ensembl
RGD		 PMID:14690604 PMID:18614044 PMID:21873635 GO_REF:0000107 MGI:2683367 MGI:3805397, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103557 (MGI:3512823|PMID:15533840)		 Ensembl
RGD		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Nek11 NIMA-related kinase 11 involved_in ISO
IBA		 (PMID:15161910)
PMID:21873635		 RGD PMID:15161910 PMID:21873635 RGD:13792537 NCBI chr 8:105,767,230...106,026,676
Ensembl chr 8:105,770,548...106,026,676 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:15538388) RGD PMID:15538388 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
UniProtKB:P26306 (MGI:1289930|PMID:9766521)		 RGD PMID:9766521 PMID:21873635 MGI:1289930, RGD:13792537 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372 		JBrowse link
G Tipin timeless interacting protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:17102137)		 UniProt
RGD		 PMID:17102137 GO_REF:0000024 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor acts_upstream_of_or_within ISO MGI:101816 (MGI:3512823|PMID:15533840) RGD PMID:15533840 MGI:3512823 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q15554 (PMID:23426265)		 Ensembl
RGD		 PMID:23426265 GO_REF:0000107 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) RGD PMID:15342622 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cell cycle process 1203
        mitotic cell cycle process 729
          mitotic cell cycle checkpoint signaling 132
            mitotic DNA integrity checkpoint signaling 85
              mitotic DNA damage checkpoint signaling + 81
              mitotic DNA replication checkpoint signaling 11
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        regulation of cellular process 12336
          regulation of cell cycle 1067
            regulation of cell cycle process 697
              regulation of cell cycle phase transition 398
                negative regulation of cell cycle phase transition 240
                  cell cycle checkpoint signaling 172
                    DNA integrity checkpoint signaling 123
                      mitotic DNA integrity checkpoint signaling 85
                        mitotic DNA damage checkpoint signaling + 81
                        mitotic DNA replication checkpoint signaling 11
paths to the root