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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538



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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) RGD PMID:19846667 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:18003703 RGD:9685165 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in ISO (MGI:5291858|PMID:21892172) RGD PMID:21892172 MGI:5291858 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO (MGI:3761050|PMID:17906627) RGD PMID:17906627 MGI:3761050 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3761050|PMID:17906627)
UniProt
RGD
PMID:17906627 GO_REF:0000024 MGI:3761050 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (MGI:5291858|PMID:21892172) RGD PMID:21892172 MGI:5291858 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) RGD PMID:17881736 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538
JBrowse link
G Snx33 sorting nexin 33 involved_in ISO (PMID:21048941) RGD PMID:21048941 NCBI chr 8:57,315,861...57,328,522
Ensembl chr 8:57,317,161...57,327,538
JBrowse link
negative regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stx1b syntaxin 1B involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) RGD PMID:27219021 MGI:6270783 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) RGD PMID:27219021 MGI:6270783 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      vesicle-mediated transport 1672
        endocytosis 744
          pinocytosis 25
            macropinocytosis 11
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 1
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 3
Path 2
Term Annotations click to browse term
  biological_process 20292
    localization 5719
      establishment of localization 5004
        transport 4684
          vesicle-mediated transport 1672
            endocytosis 744
              pinocytosis 25
                macropinocytosis 11
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 1
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 3
paths to the root