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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538



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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:20,036,430...20,353,431
Ensembl chr 7:20,036,944...20,353,420
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chr 2:69,474,011...69,574,427
Ensembl chr 2:69,474,031...69,574,424
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:67,314,651...67,365,060
Ensembl chr 9:67,314,484...67,365,059
JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:33,097,329...33,125,820
Ensembl chr13:33,097,393...33,125,818
JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
JBrowse link
G RAB34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chr12:44,951,989...44,956,458
Ensembl chr12:44,951,210...44,956,119
JBrowse link
G SNX33 sorting nexin 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:57,999,447...58,015,598
Ensembl chr 7:57,999,459...58,014,441
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,077...39,129,781
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chr 5:79,356,046...79,412,235
Ensembl chr 5:79,356,067...79,412,235
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    cellular process 16883
      vesicle-mediated transport 1583
        endocytosis 703
          pinocytosis 24
            macropinocytosis 10
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 0
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 2
Path 2
Term Annotations click to browse term
  biological_process 17813
    localization 5385
      establishment of localization 4687
        transport 4381
          vesicle-mediated transport 1583
            endocytosis 703
              pinocytosis 24
                macropinocytosis 10
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 0
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 2
paths to the root