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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538


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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) UniProt PMID:19846667 NCBI chrNW_004624756:1,446,633...1,751,043
Ensembl chrNW_004624756:1,446,200...1,751,211
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chrNW_004624828:2,727,136...2,805,248
Ensembl chrNW_004624828:2,727,112...2,807,319
JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in ISO (MGI:5291858|PMID:21892172) UniProt PMID:21892172 MGI:5291858 NCBI chrNW_004624733:19,882,234...20,315,211
Ensembl chrNW_004624733:19,883,027...20,315,128
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004624807:4,726,511...4,774,945
Ensembl chrNW_004624807:4,724,234...4,796,143
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004624730:4,446,815...4,492,753
Ensembl chrNW_004624730:4,446,850...4,476,630
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (MGI:5291858|PMID:21892172) UniProt PMID:21892172 MGI:5291858 NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000
JBrowse link
G Rab34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chrNW_004624786:1,286,886...1,291,582
Ensembl chrNW_004624786:1,286,887...1,291,419
JBrowse link
G Snx33 sorting nexin 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624894:545,411...557,347
Ensembl chrNW_004624894:544,791...557,563
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004624822:31,175...74,252
Ensembl chrNW_004624822:33,880...74,308
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004624750:3,789,015...3,827,079
Ensembl chrNW_004624750:3,789,022...3,827,079
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15028
    cellular process 14201
      vesicle-mediated transport 1451
        endocytosis 634
          pinocytosis 23
            macropinocytosis 10
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 0
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 2
Path 2
Term Annotations click to browse term
  biological_process 15028
    localization 4927
      establishment of localization 4263
        transport 3971
          vesicle-mediated transport 1451
            endocytosis 634
              pinocytosis 23
                macropinocytosis 10
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 0
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 2
paths to the root