Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
go back to main search page
Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538



show annotations for term's descendants           Sort by:
macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IDA (PMID:19846667) UniProt PMID:19846667 NCBI chr 6:25,279,374...25,620,530
Ensembl chr 6:25,279,078...25,620,530
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 5:169,637,275...170,083,382
Ensembl chr 5:169,637,268...170,083,382
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281
JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:50,611,520...50,649,291
Ensembl chr 3:50,611,520...50,649,291
JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RAB34 RAB34, member RAS oncogene family NOT|involved_in IDA (PMID:17881736) UniProt PMID:17881736 NCBI chr17:28,714,281...28,718,428
Ensembl chr17:28,714,281...28,718,429
JBrowse link
G SNX33 sorting nexin 33 involved_in IMP (PMID:21048941) UniProt PMID:21048941 NCBI chr15:75,647,912...75,662,301
Ensembl chr15:75,647,912...75,662,301
JBrowse link
negative regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STX1B syntaxin 1B involved_in ISS ParkinsonsUK-UCL GO_REF:0000024 NCBI chr16:30,989,256...31,010,638
Ensembl chr16:30,989,256...31,010,638
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr12:105,173,300...105,236,174
Ensembl chr12:105,173,297...105,236,203
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      vesicle-mediated transport 1778
        endocytosis 810
          pinocytosis 25
            macropinocytosis 11
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 1
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 3
Path 2
Term Annotations click to browse term
  biological_process 19770
    localization 5924
      establishment of localization 5199
        transport 4854
          vesicle-mediated transport 1778
            endocytosis 810
              pinocytosis 25
                macropinocytosis 11
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 1
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 3
paths to the root