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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538


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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:46,637,416...46,979,061
Ensembl chr17:46,635,199...46,978,932
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chr 6:9,718,014...9,830,061
Ensembl chr 6:9,718,244...9,831,206
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:71,866,196...72,299,066
Ensembl chr23:71,866,251...72,299,056
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:22,632,180...22,681,250
Ensembl chr25:22,629,729...22,681,373
JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chr22:11,998,774...12,036,477 JBrowse link
G PYCARD PYD and CARD domain containing involved_in ISO (MGI:5291858|PMID:21892172) UniProt PMID:21892172 MGI:5291858 NCBI chr 5:27,892,332...27,894,386
Ensembl chr 5:27,889,230...27,893,697
JBrowse link
G RAB34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chr16:22,482,012...22,486,159
Ensembl chr16:22,481,747...22,485,186
JBrowse link
G SNX33 sorting nexin 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:7,776,989...7,787,873
Ensembl chr26:7,778,390...7,786,591
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chr22:18,546,694...18,591,239
Ensembl chr22:18,546,751...18,589,552
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:100,400,093...100,469,234
Ensembl chr11:100,400,084...100,462,507
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16766
    cellular process 15757
      vesicle-mediated transport 1584
        endocytosis 694
          pinocytosis 24
            macropinocytosis 10
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 0
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 2
Path 2
Term Annotations click to browse term
  biological_process 16766
    localization 5329
      establishment of localization 4608
        transport 4298
          vesicle-mediated transport 1584
            endocytosis 694
              pinocytosis 24
                macropinocytosis 10
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 0
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 2
paths to the root